Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"TCRb"”.
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Feedback Control of Tcrb Gene Recombination
North Carolina State University Theses Microbiology.
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Vβ Recombination Signal Sequences Mediate Monoallelic And Monogenic Tcrβ Gene Assembly: Implications For The Tcrβ Repertoire And Allelic Exclusion In Health And Disease
… segment recombination signal sequences (RSSs) of Tcrb and Igh loci that target RAG have been proposed to render V recombination inefficient and mediate monoallelic V-to-DJ recombination. To test the role of Vβ RSSs in promoting Tcrb allelic exclusion, I created and studied mice harboring …
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The Role of Epigenetics in Regulating V(D)J Recombination and Allelic Exclusion
… and inaccessible RSSs on the Tcr loci. We used Tcrb and Tcra alleles which lack various cis-elements (e.g. enhancers and promoters) and terminate transcription. By comparing nucleosome organization and histone octamer occupancy, we found that accessible alleles are characterized by lower histone …
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Isolation And Characterisation Of Immunoglobulin Gene Superfamily Molecules From Lower Vertebrates (Fish)
… primers to the TCR β chain variable region (TCRBV) sequences of the homed shark to allow the amplification of the TCR-like genes from dogfish, Scyliorhinus canicula; secondly, to employ a similar strategy using degenerative primers to the banded houndshark MHC class-I α3 DNA sequence, to …
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Modulation of the NFAT signaling pathway by protein kinase B (PKB) ; a perspective study in the context of thymocyte development and T cell function
… is due to the expression of RAG1 and subsequent TCRb chain expression. CsA treatment of neonatal thymic lobes from dCam mice restores normal thymocyte development, indicating involvement of NFATs in the severe block in dCam thymocyte development.Confocal studies clearly established that compared …
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Untersuchungen zur Rolle von CD8 bei der Aktivierung von gamma-delta-T-Zellen der Ratte
… Dagegen sind die CDR3-Regionen der TCRb-Kette sehr kurz, was wahrscheinlich durch die notwendige Interaktion des MHC-Peptid-Komplexes mit allen drei CDR-Schleifen bedingt wird. Daraus wurde geschlossen, daß die Bestimmung der CDR3d-Längen Aussagen über eine mögliche MHC-Restriktion …
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Untersuchung der Entwicklung der T-Zell-Rezeptor assoziierten Signalleitung im Thymus auf Einzelzellniveau
Die frühe Entwicklung der ab-T-Zelllinie scheint von Zytokinen abhängig zu sein, vor allem von IL-7, das bei dieser Kontrolle eine wichtige Rolle spielt. Die späteren Differentierungsereignisse hingegen sind vom CD3-Komplex kontrolliert. Die Umstellung von Zytokin- zu CD3-Kontrolle in der …