Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 17 of 17 for “"TCR signaling"”.
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Functional relationships among lck kinase and the lat and grb2 adaptors in the intracellular signaling cascade of the tcr/cd3 complex: implications in thymic development and lymphocyte activation
… and for this purpose, they express the TCR receptor in their membrane, which upon activation triggers a very complex intracellular signaling. Failures in these intracellular signals can lead to the loss of tolerance or to the development of deficient T lymphocytes. In this work, we …
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Re-Designing Cancer Immunotherapy to Enhance Anti-Tumor Immunity
… compared to either alone. Mechanistically, TCR activation of pre-existing CD8+ T cells synergizes with CD40L activation of DCs inside the TME to control tumor growth. We found exogenous TCR signals can better re-activate TIL, but distal tumor control required T cells from the draining lymph …
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Regulation Of Selection And Central Tolerance By The N-Terminal Region Of Rag1
… and self-reactive T cell receptors (TCRs) from the peripheral repertoire. These mechanisms rely on self-antigen:TCR interactions of intermediate affinity during development. However, the requirement for TCR selection on self-peptides results in a tenuous state where some autoreactive …
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Nicotine and TNF alpha, modulators of T cell signaling-effects on T cell development in fetal thymus organ culture
… have the ability to influence T cell receptor (TCR) signaling and the maturational capacity of treated cultures. FTOC treated with low concentrations of nicotine produced more immature T cells and fewer mature T cells. These expanded populations of cells also expressed CD69, CD95 (FAS) and …
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Characterization of a Novel Signaling Motif in the CD3 ε Subunit of the T Cell Receptor
The T cell receptor (TCR) complex consists of the ligand-binding α/β heterodimer as well as four associated signaling chains (CD3 γ, δ, ε, and ζ). Each of the CD3 subunits contains one or more copies of a signaling motif termed an immunoreceptor tyrosine-based activation motif (ITAM). …
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Molecular Mechanisms and Antigen Receptor Requirements for Lymphocyte Adaptation to Intestinal Tissues
… transcriptional mechanisms and T cell receptor (TCR) signaling requirements of CD4+ T cell plasticity and adaptation in the intestinal tissues. Within the intestine, peripherally induced Foxp3+ regulatory T cells (iTregs), which are instrumental in limiting inflammatory responses to non-self …
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The roles of Cabin1 and Left1 in T cell development
… inhibit calcineurin activity following TCR signaling and transcriptional activation of Nur77 by MEF2. The role of these interactions in vivo was investigated using a mutant mouse strain that expresses a truncated Cabin 1 lacking the C-terminal calcineurin and MEF2 binding domains. …
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E3 Ubiquitin Ligase Cbl-b deficient T cells resist Treg cell-mediated suppression and enhance anti-tumor immunity
… have suggested that alterations in T cell signaling networks can result in T cells that are resistant to the suppressive effects of Treg cells. Here, we specifically investigated the role of E3 ubiquitin ligase Cbl-b in establishing T cell resistance to Treg cell-mediated suppression. …
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Factors Influencing Regulatory T Cell Maintenance for the Control of Autoimmunity
… but not hematopoietic vitamin D receptor signaling was important for this increase in Treg numbers and MC903 treatment did not lead to changes in Treg development, but drove increased Treg proliferation. However, TSLP-R expression by Tregs themselves was not required for the expansion …
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Cytokine priming enables triggering of naive auto-reactive CD8[superscript +]T cells by weak agonist ligands of the TCR
… signal is mediated via the T cell receptor (TCR) following its interaction with the peptide presented on class-I major histocompability complex (MHC-I) molecules. The second signal is delivered via the co-stimulatory receptors upon recognition of their ligands on antigen presenting cells. …
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The role of Fyn and B-cell expressed ADAM10 in early B cell development, germinal center formation and terminal B cell differentiation
… both the B cell and T cell receptor (BCR and TCR, respectively). While Fyn-deletion did not impair the development of immature T cells and B cells, TCR signaling was altered in mature T cells. Our results demonstrate that Fyn-KO mice have significantly low basal levels of IgG1 and IgG2a. …
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Costimulatory function of CD44
… to require two signals via engagement of the TCR and a costimulatory molecule. However, the signaling cascade of costimulatory molecules has remained elusive. Here, I provide evidence that CD44 supports proliferation as well as apoptosis mainly, if not exclusively, by enhancing signal …
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Spatial Dynamics and the Mechanoresponse in CD4+ T Cell Activation
… Activation of naïve T cells proceeds through TCR engagement and is further augmented by CD28 costimulation: ensuring T cell survival and conferring numerous functional capabilities. The work in this dissertation highlights the spatial and temporal dynamics that regulate the initial coupling of …
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Studies on the Leukocyte-Associated Ig-Like Inhibitory Receptor-1 Signaling Pathway in T Lymphocytes
… activation. I investigated whether the LAIR-1 signaling complex contains SH2 domain-containing phosphatase (SHP)-1, SHP-2, C-terminal src kinase (Csk), and/or the protein tyrosine phosphatase, non-receptor 22 (PTPN22), whether these phosphatases are activated upon LAIR-1 and its ligand …
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On Thymic Regulatory T-Cell Ontogeny
… including the rearrangement of T-cell receptor (TCR) gene segments, β-selection of cells expressing a functional TCRβ chain, positive selection of cells followed by CD4/CD8 lineage specificity, and negative selection or clonal deletion to eliminate autoreactive T cells. The induction of the Treg …
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Analysis of DOCK2 and SENP2 mutations on the immune system and CD8 T cell survival
… to anti-CD3 in vitro, consistent with intact TCR signaling, and peripheral CD44high activated memory T cells were present in normal or increased numbers consistent with homeostatic proliferation. Thymocytes showed evidence of developmental defects, including 50% decreased CD4+CD8+ double …
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Analysis of DOCK2 and SENP2 mutations on the immune system and CD8 T cell survival
… to anti-CD3 in vitro, consistent with intact TCR signaling, and peripheral CD44high activated memory T cells were present in normal or increased numbers consistent with homeostatic proliferation. Thymocytes showed evidence of developmental defects, including 50% decreased CD4+CD8+ double …