Global ETD Search
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Showing 1 to 5 of 5 for “"TCR affinity"”.
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Engineering and Characterization of High-Affinity T Cell Receptors
In Chapter 6, the role of TCR affinity in T cell activation was studied using CD8-negative T cells, as well as T cells expressing the co-receptor CD8. The peptide sensitivity of T cells that expressed the highest-affinity TCRs reached a plateau, suggesting the existence of an affinity maximum for T …
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Single-cell NAD(H) levels predict clonal lymphocyte expansion dynamics
Adaptive immunity requires the expansion of high affinity lymphocytes from a heterogenous pool. While current models explain this through signal transduction, we hypothesized that antigen affinity tunes discrete metabolic pathways to license clonal lymphocyte dynamics. Herein we identify NAD …
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Visualizing Dendritic Cells In Vivo
… are similar, we investigated the role of TCR affinity for MHC:peptide complexes (pMHC) in these interactions during tolerance induction. We observed that pMHC potency correlates with T cell proliferation, Ca<sup>2+</sup> flux and with early antigenspecific arrest; T cell anergy was induced …
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PKB/Akt : a critical regulator of lymphocyte, development and function
… enhanced proliferation after T cell receptor (TCR) engagement compared to wild type (wt) mice. Astonishingly, myr PKB tg thymocytes were capable to proliferate in response to PMA only and were also less sensitive to inhibition by the calcineurin inhibitors CsA or FK506, which indicates the …
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Histone Modifications in Trypanosoma Brucei
<p>Trypanosoma brucei maintains an infection in its mammalian host by switching its surface antigen, thus evading host antibodies, in a process known as antigenic variation. Variant surface glycoproteins (VSG), the surface antigen, are expressed from genes located at as many as 20 Expression Sites …