Global ETD Search
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Showing 1 to 16 of 16 for “"TCF4"”.
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TCF4: An unexpected journey
Contains fulltext : 175283.pdf (Publisher’s version ) (Open Access)
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TCF4-mediated Transcriptional Regulation of Krüppel-like Factor 4 Gene
… 결정을 드러내도록 노력하기 위해 우리는 transcription factor 4 (TCF4) 단백질이 binding 하는 것으로 알려진 두 개의 AT-/TA-CAAAG conserved motif를 확인하였다. Transcription factor 7-like 2(TCF7L2)로 알려진 TCF4은 transcription factor의 하나이고, 성인의 장에서 Wnt/β-catenin 신호 전달 활동을 중재하고, 결장 표면에서 발현되는 primary TCF/LEF family member이다. KLF4 유전자의 변화활동이 …
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TCF4 Is a Key Mediator of Cell Identity and Oncogenesis in Neuroblastoma
… states. We report the bHLH transcription factor TCF4 (E2-2) is a critical NB dependency gene that significantly contributes to these identity states through its heterodimerization with cell identity specific bHLH TFs. Mechanistically, we show that TCF4 promotes cell proliferation through direct …
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Signaling Pathway Inhibitor Library Screening Reveals B-Catenin/TCF4 as a Novel Telomerase Regulator in Cancer cell lines
… for some of the major types of cancer. ?-catenin/TCF4 complex was identified as a novel TA regulator from the screen and was later found to inhibit TA via transcription regulation of hTERT (human TERT). Activation of the Wnt pathway either by Wnt ligand (Wnt-3a) or LiCl (activates Wnt signaling by …
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Trim28 Interacts With Ezh2 to Regulate Its Activity
… transcription factor binding motifs, including TCF4 and RBP-J (a Notch effector), at TRIM28 binding sites. The promoter of <em>AXIN2</em>, which encompasses a TCF4 binding motif, is a direct transcriptional activation target of TRIM28. Collectively, we demonstrated a mechanism of regulation of …
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Sequential Transcriptional Gates in The Thalamo-Cortical Circuit Coordinate Memory Consolidation
… regulators—<em>Camta1</em> and <em>Tcf4 </em>in the ANT, and <em>Ash1l</em> in the ACC—orchestrated region specific molecular programs that enabled entry into these macrostates. Targeted CRISPR-knockout studies revealed that while these transcriptional regulators had no effects on …
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Synthetic Essentiality of Tdo2 In Apc-Mutated Colorectal Cancer
… <p>Mechanistically, APC loss results in TCF4/b-catenin-mediated activation of</p> <p>TDO2 gene transcription. TDO2 in turn activates the Kyn-AhR pathway</p> <p>which boosts glycolysis, promotes proliferation, and upregulates CXCL5</p> <p>which recruits macrophages into the tumor …
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Untersuchungen zur Funktion des basischen Helix-Loop-Helix (bHLH)-Transkriptionsfaktors ME2 bei Lern- und Gedächtnisprozessen in der Maus
ME2 (Tcf4) gehört zu der Familie der basischen Helix-Loop-Helix (bHLH) Transkriptionsfaktoren und aktiviert die Transkription von Zielgenen mittels Bindung an E-Boxen. Die ME2 mRNA-Expression bleibt in adulten zentralen Nervensystem (ZNS) erhalten. Da heterozygote ME2-knockout-Mäuse keinen …
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The role of Ten Eleven Translocation enzymes in the hair follicle mesenchyme
… signature DP genes such as Bmpr1a, ALPL, Tcf4 and SOX2.
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T3-induced hepatocyte proliferation requires β-catenin and is protein kinase A dependent
… mice (KO). In fact, T3 induced β-catenin-TCF4 reporter activity both in vitro and in vivo. Livers from T3-treated mice demonstrated no changes in Ctnnb1 expression, activity of Glycogen synthase kinase-3β known to phosphorylate and eventually promote β-catenin degradation, or …
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Investigating the Immunological Effect of Schizophrenia-Related Antigens and Anti-psychotic Medication.
… IgG levels and three derived from TSNARE1, TCF4 and VRK2 showed a decrease. As the initial study was conducted with medicated patients with chronic schizophrenia and healthy controls from a European-derived Caucasian population, the initial findings were thus replicated in …
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Function of the PDLIM2 protein in oncogenic Wnt signalling pathways
… activity by the interaction of PDLIM2 with TCF4 at the nucleus. Evaluation of PDLIM2 in macrophages and co-culture studies with cancer cells and fibroblasts showed the influence exerted on PDLIM2 by paracrine cues. Thus, PDLIM2 integrates cytoskeleton signalling with gene expression by …
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Elucidating the Genetic Basis of Fuchs Endothelial Corneal Dystrophy
… with a genetic variant, rs613872 in the <italic>TCF4</italic> locus on chromosome 18 that has been consistently and reproducibly associated with FECD, to influence FECD susceptibility. Together, these findings indicate that the genetic basis of FECD is complex, and recent advances in the field …
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Role of ASCL1 and Its Interactors in Neuroblastoma
… most of its interactors, including E-protein TCF4, compared to a more responsive cell line. This work suggests understanding ASCL1 interactors could help explain whether this key transcriptional regulator promotes cell proliferation or differentiation of NB, allowing modulation of …
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Uncovering the molecular pathways of MBD5 in neurodevelopmental disorders
… Smith-Magenis (SMS, RAI1), Pitt-Hopkins (PTH, TCF4), Angelman (AS, UBE3A) and Rett (RTT, MECP2) syndromes, including ID, speech impairment, and seizures, in addition to other autism spectrum disorder (ASD)-associated phenotypes (associated with mutation of MBD1). The methyl-CpG binding domain …
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THE ROLE OF POU5F1B IN PROSTATE CANCER
… prostate cancer cells increases Wnt1, TCF1, and TCF4 expression, as well as increased Wnt/β-Catenin signaling - indicating the induction of epithelial-to-mesenchymal transition (EMT) in POU5F1B overexpressing cells(2). Consistently, qPCR analysis found that POU5F1B overexpression significantly …