Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 65 for “"TCF"”.
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Tumor Response TCF-4/β-Catenin Regulatory Elements for Enhancing Cancer Gene Therapies
… protein levels, followed by transactivation of Tcf-4/β-catenin responsive genes. The effectiveness of a Tcf-4/β-catenin transcriptional enhancer element in combination with a c-fos or carcinoembryonic antigen promoter was tested for its ability to act as a tumor specific regulator of gene …
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The Study of Wnt Signaling Effector POP-1/TCF in C. Elegans Early Embryos
In C. elegans embryos, the combined Wnt/MAPK pathway polarizes the founder cell of mesendoderm, EMS blastomere, such that EMS produces two daughters with distinct developmental fates. The posterior daughter E, whose fate is specified by Wnt/MAPK, generates intestinal tissues (endoderm), whereas the …
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Greening the invisible hand : how environmental non-governmental organizations (NGOs) succeed and fall in technology change
… white paper products. Totally chlorine-free (TCF) bleaching emerged as the cleanest bleaching technology in commercial use: it eliminated organochlorine water pollution. The Swedish environmental organizations, with help from Greenpeace Germany, were more successful at diffusing TCF bleaching. …
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The effect of the universal "treating customers fairly" principles and the new policyholder protection rules on insurance claims in South Africa
Treating Customers Fairly (TCF) has finally been formally promulgated into the Insurance sector of South Africa via the 2017 Policyholder Protection Rules (2017 PPR's). It has been a long-standing initiative by the market conduct regulator of the financial sector, that instils confidence in …
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Wnt/beta-Catenin-Zielgene in der Mausentwicklung
… ist das Protein beta-Catenin, das an LEF/TCF-Transkriptionsfaktoren bindet und so Zielgene des Wnt/beta-Catenin-Signalwegs aktiviert. Ziel dieser Arbeit war die Identifizierung solcher Zielgene in der Maus. Als experimentelles System dienten dabei Maus ES-Zellen, in denen durch gemeinsame …
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Identifying the effects of land use and policy on disturbance regimes in the Teanaway Community Forest, Washington
… composition of the Teanaway Community Forest (TCF). This research requires 1) remote sensing techniques to reconstruct the vegetation history and extent of the forest and to characterize the overall effects of land use change in the TCF and 2) the Forest Vegetation Simulator to predict future …
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Fatores relacionados ao retardo pré-hospitalar de pessoas com infarto agudo do miocárdio
… TD = 20/180 min.; TT = 15/21min. 25; TCF = 1245/4980 min. A comparação entre as medianas para TD e variáveis sociodemográficas, nº de eventos prévios, local e turno do IAM não mostrou diferença estatisticamente significante. Maior mediana para TD foi encontrada para os que informaram …
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Multi-scale Coherent Structure Extraction and Visualization for Flow Analysis
… time-independent) turbulent Taylor-Couette flow (TCF), and (3) a new framework to extract and visualize large-scale coherent structures in time-dependent shear flows using dynamic mode decomposition (DMD). The TAC-based framework enables us to select pathlines that can effectively represent the …
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Fractional transport of bed-material load in sand-bed channels
… the concept of the transport capacity fraction (TCF) approach. The bed-material concentration for a given size fraction is obtained by weighting the bed-material concentration, C1, with a transport capacity distribution function, Pci. The procedure and a detailed example problem showing the use …
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Hochdruck-Raman-Lichtstreuexperimente an überkritischem Cyclopropan und Stickstoff-Xenon-Gemischen in einem weiten Dichtebereich
… results. The Raman-time-correlation-functions (TCF) of the oblate Cyclopropane molecule were investigated in a range of reduced density: 0,25<= Rho r = Rho / Rho c <= 2,00 at a temperature of T = 413 K. There are no interaction-induced contributions to the scattered light, whereas the …
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Aplicación de técnicas quimiométricas a la resolución de señales electroquímicas solapadas
… (DCF) and 2,4,6-trichlorophenol (TCF). Both systems were studied with amperometric electrochemical sensors: the hanging mercury drop electrode, for the inorganic mixtures, and Sonogel-Carbon electrodes, recently developed by our research group, for the organic system. With respect …
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Effects of Binge Alcohol Exposure on Canonical Wnt Signaling During Fracture Repair
… test this, C57BL/6 or beta-catenin/TCF-reporter male mice were exposed to intraperitoneal alcohol or saline for 3 consecutive days for either 1 week or 2 week cycles. One hour after the final injection, mice received a stabilized tibial fracture and were sacrificed 1,2,3, 6, 9, or 14 …
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Interactions between BMP and Canonical Wnt Signaling Regulate Critical Stages of the Osteoblast Lifecycle
… a lineage allocation mechanism requiring both Tcf/Lef-dependent and Tcf/Lef-independent mechanisms. We next examined BMP/Wnt interactions during proliferation of osteoprogenitors, by focusing on Smad4, a central mediator of the greater TGF-beta/BMP pathway. Acute, tamoxifen-induced deletion of …
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RacGap50C Is a Novel Negative Regulator of Wnt Signaling
… the nucleus and binding the transcription factor TCF. However, reporter gene activity is significantly diminished in cells expressing RacGap50C or Pav, indicating an inability of this nuclear BetaCatenin to activate transcription. RacGap50C and Pav are also found in the nucleus of interphase cells …
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Thermally Actuated Resonant Silicon Crystal Nanobalances
… A significant decrease of the large negative TCF for the resonators has been attained by doping the devices with a high concentration of phosphorous, resulting in even slightly positive TCF for some of the devices. This is also expected to improve the phase noise characteristics of oscillators …
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The role of FOXK transcription factors in Wnt signal transduction
… to enhancers by T-cell transcription factors (TCF), and core components include the chromatin reader Pygopus as well as the transcriptional repressor Groucho/TLE3. While much is known about the basic interactions within the enhanceosome, it remains elusive how the enhanceosome accesses native …
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Mechanistic Dissection of Tcf7l1-Dependent Enhancer Decommissioning During Exit from Naïve Pluripotency
… to Wnt/β-catenin signaling. Here, we show that Tcf7l1 functions as a linchpin factor that connects the two outcomes via effects at Tcf7l1-bound cis-regulatory elements in mouse pluripotent stem cells. A combination of gene knockout and inducible expression lines of ESC were generated to …
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COMPARATIVE CELL BASED FUNCTIONAL ANALYSIS OF KEY WNT/BETA-CATENIN PATHWAY GENES AND GENE MUTATIONS
… transcription of its target genes by binding TCF/LEF transcription factors. Aberrant Wnt/Beta-catenin signaling activity leads to misregulation of proliferation and metabolic pathways and has been linked to a number of diseases.
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THE ROLE OF CD4+ T MEMORY SUBSETS IN HIV INFECTION: IMMUNE RESPONSE IN PEOPLE WITH HIV AND LATENCY ESTABLISHMENT
… immune reconstitution. In these participants, TCF-1, a master regulator of T cell stemness, was less expressed across all T memory subsets. It has been recently shown that GSK3β inhibition could arrest CD8+ T cell differentiation, trigger the formation of stem cell-like memory T cells, and a …
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