Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 44 for “"TCDD"”.
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Toxicity of TCDD in the mouse antral follicle
… 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) is a potent ovarian toxicant. These studies were designed to characterize the actions of TCDD on steroidogenesis, growth, and atresia of intact mouse antral follicles in vitro. Interestingly, TCDD has been shown to act mainly through binding …
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Immunotoxicity of TCDD: role of Fas expression and MHC phenotype on TCDD-mediated thymic atrophy and decrease in peripheral T cell responsiveness
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is well known for its immunotoxic effects particularly on the thymus as well as on T and B lymphocyte functions. Previous studies have suggested that TCDD may induce apoptosis in thymocytes although its demonstration in vivo has met with limited success. …
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Einfluß von TCDD auf den Arzneistoffwechsel am Beispiel des Imipramin
… Sevesogift 2,3,7,8-Tetrachlorodibenzo-p-dioxin, TCDD, ist das stärkste bisher vom Menschen in die Umwelt gebrachte Gift. Ein großer Anteil seiner toxischen Wirkungen wird auf das hohe Induktionspotential für fremdstoffmetabolisierende Enzyme zurückgeführt. Ziel dieser Arbeit war die Untersuchung …
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Apoptosis as a Mechanism of 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD)-Induced Immunotoxicity
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is a highly toxic environmental pollutant and is well known for its immunotoxic effects, particularly on the thymus. The exact mechanism by which TCDD induces thymic atrophy is not known. In the current study, we investigated whether TCDD triggers …
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Mechanism of TCDD-Induced Immunotoxicity: The Role of Cell Activation in the Generation of Toxicity
… functions. Previous studies suggested that TCDD exerted immunotoxic effects only on cells differentiating in response to antigenic challenge. To this date, no work has been done to characterize the long-term effects of TCDD on the activated cells. Additionally, no studies have been done to …
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Immunotoxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and Diethylstilbestrol (DES) in the Fetal Mouse Thymus and Liver
… (DES) and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) have been identified as immunotoxicants causing thymic atrophy, thymocyte hypocellularity, phenotypic changes detected by CD4 and CD8 surface antigens, and progenitor T-cell targeting in the fetal mouse. We hypothesized that gestational …
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Consequences of Aryl hydrocarbon receptor activation in dendritic cells
<p>TCDD (dioxin) causes immunosuppression via activation of the Aryl hydrocarbon receptor (AhR). Dendritic cells (DCs), the professional antigen-presenting cells in the immune system, are adversely affected by TCDD. However, limited information exists regarding the effects of AhR activation on DCs. …
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Consequences of Aryl hydrocarbon receptor activation in dendritic cells
<p>TCDD (dioxin) causes immunosuppression via activation of the Aryl hydrocarbon receptor (AhR). Dendritic cells (DCs), the professional antigen-presenting cells in the immune system, are adversely affected by TCDD. However, limited information exists regarding the effects of AhR activation on DCs. …
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CONSEQUENCES OF ARYL HYDROCARBON RECEPTOR ACTIVATION IN STEADY-STATE AND INFLAMMATORY DENDRITIC CELLS
… including 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and TCDD-like compounds. Exposure to environmentally relevant levels of TCDD and TCDD congeners has been shown to cause immune suppression, yet the mechanisms underlying TCDD-induced immune suppression remain poorly understood. Dendritic cells …
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CONSEQUENCES OF ARYL HYDROCARBON RECEPTOR ACTIVATION IN STEADY-STATE AND INFLAMMATORY DENDRITIC CELLS
… including 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and TCDD-like compounds. Exposure to environmentally relevant levels of TCDD and TCDD congeners has been shown to cause immune suppression, yet the mechanisms underlying TCDD-induced immune suppression remain poorly understood. Dendritic cells …
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Developmental Exposure to 2,3,7,8-Tetrachlorodibenzo-p-dioxin: Induced and Exacerbated Autoimmunity in Adulthood
… 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) exposure can permanently alter immune system ontogeny, resulting in the dysregulation of a number of vital immune pathways. We hypothesized that developmental exposure to TCDD may also impair the establishment of self-tolerance, resulting in …
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Zebrafish cardiovascular cDNA microarrays : expression profiling and gene discovery in embryos exposed to 2,3,7,8-Tetrachlorodibenzo-ρ-dioxin
2,3,7,8-Tetrachlorodibenzo-ρ-dioxin (TCDD) is a potent teratogen that impacts the developing cardiovascular system. Hallmarks of embryonic exposure include cardiac malformation, impaired circulation, loss of erythrocytes, pericardial and yolk sac edema, and early life stage mortality. However, the …
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The Effects of Lactational and Gestational Exposure to 2,3,7,8-Tetrachlorodibenzo-P-Dioxin or Coplanar PCBs on Spatial Learning and Memory
… selection. A final study was conducted, in which TCDD-exposed animals were tested on the 8-arm RAM with all of the arms baited or on the 12-arm RAM with only 8 of the 12 arms baited. It was hypothesized that if TCDD-exposed rats had better memory, they should show improvements relative to controls …
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Effects of Gestational and Lactational Exposure to 2,3,7,8-Tetrachlorodibenzo-P-Dioxin or Coplanar PCBs on Reproductive Development and Sexually Dimorphic Behaviors in Rats
… non-reproductive behaviors were affected in TCDD and coplanar PCB exposed rats. In the initial study, the play behavior in TCDD exposed rats was suppressed. However in the follow-up study, when play behavior was tested with a different protocol than in the initial study, the effects were not …
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Characterization of serum-induced CYP1A1 expression and activity in mouse embryo fibroblasts
… of environmental contaminants that include TCDD. Using a TCDD dose-response treatment in MEFs, we observed a super induction of CYP1A1 with newborn calf serum (NCS) in the presence (10nM/15nM) of TCDD. In addition to NCS, fetal bovine serum (FBS) also has the capability to yield a CYP1A1 …
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Molecular Insights and Physiological Consequences of Aryl Hydrocarbon Receptor Regulated Plasminogen Activator Inhibitor-1 Expression
… agonist 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) following 70% partial hepatectomy (PH). One reported target of the AhR that may account for suppression of the regenerative response is plasminogen activator inhibitor-1 (PAI-1), which negatively regulates the cleavage and activation of …
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Characterization of resistance to halogenated aromatic hydrocarbons in a population of Fundulus heteroclitus from a marine superfund site
… either site. 2,3,7,8-Tetrachlorodibenzo-p-dioxin TCDD and J3-naphthoflavone BNF induced CYP1A1 activity to the same level in primary cultures ofhepatocytes from either SC orNBH fish. However, hepatocytes from NBH fish were 14-fold less sensitive to TCDD and 3-fold less sensitive to BNF than …
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Identification de co-régulateurs impliqués dans la réponse transcriptionnelle induite par les récepteurs AhR et ER[alpha]
… CYP1A2, CYP1B1, suite au traitement avec le TCDD. Le niveau d'induction du gène CYP1A1 diminue alors que celui du gène CYP1B1 reste constant. Cela diminuerait le ratio CYP1A1/CYP1B1 et ferait augmenter le risque pour le cancer. En effet, CYP1A1 métabolise l'oestrogène (E2) en 2-OHE2 qui est …
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Characterization of Aryl Hydrocarbon receptor and Kruppel-Like-Factor-6 interaction
… including 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Upon ligand activation, the AhR translocates to the nucleus, dissociates from its chaperone complex, and dimerizes with the Aryl Hydrocarbon Receptor Nuclear Translocator (ARNT). The canonical AhR-ARNT complex binds to DNA regions known as …
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Consequences of Aryl Hydrocarbon Receptor Activation in Crohn's Disease
… ligand 2,3,7,8-tetrachlorodibenzo-pdioxin (TCDD), and natural sources, such as indole-3-carbinol (I3C) and indirubin. Crohn's disease, a chronic inflammatory state of the gastrointestinal tract, affects millions worldwide; however, the exact cause is unknown and treatments do not cure the …
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