Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"TCA cycle intermediates"”.
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Investigation of Gut-Derived Circulating Succinate in Metabolism and Liver Signaling
<p>The tricarboxylic acid (TCA) cycle is the epicenter of cellular aerobic metabolism and accounts for the majority of cellular ATP production. In addition to its use in anabolic and catabolic processes, TCA cycle intermediates may serve as signaling molecules. The TCA cycle intermediates succinate …
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Molecular and cellular investigations of photosynthesis driven carbon fixation in the seagrass Zostera muelleri
… in the photorespiratory and recycling of TCA cycle intermediates were down-regulated. In addition, we found that under reduced irradiance conditions, ¹³C uptake was reduced and this correlated with a down-regulation of genes involved in photosynthetic, photorespiratory and recycling of TCA …
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Analysis of the hex regulon in Pseudomonas aeruginosa
… and catabolite repressed when grown on TCA cycle intermediates. The HexR protein is a negative transcriptional repressor and the Crc protein participates in regulation of these genes and has been shown to be necessary for biofilm formation. The main objective of this study was to analyze …
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Functional and mathematical analysis of the glyoxylate shunt in Streptomyces coelicolor
… aceA, ccr and genes encoding tricarboxylic acid (TCA) cycle genes revealed that all are subject to a similar level of purifying selection pressure. The operons of the glyoxylate shunt and the ethylmalonyl-CoA pathway share a 15 bp palindromic motif in their upstream sequences, which was also found …
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Finding Typhoid Mary: Identifying Latent Carriers of Salmonella enterica serovar Typhimurium
… Isocitrate lyase is part of the glyloxylate cycle. Some bacterial species have developed a mechanism to utilize acetone as a carbon source to synthesize tricarboxylic acid (TCA) cycle intermediates. This anaplerotic reaction allows organisms to conserve carbon and use alternative carbon …
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Acetyl-CoA metabolism and human trophoblast differentiation
… result in substantial changes to glycolytic or TCA cycle intermediates, nor mitochondrial respiration, suggesting that the phenotypic changes were due to impaired epigenetic regulation rather than metabolic deficits. Moreover, ACLY depletion impaired the ability of cytotrophoblasts to form …
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The role of NAD+ compartmentation and dynamics in Arabidopsis thaliana
… . Furthermore, higher levels of photorespiratory intermediates such as glutamate and glycine were found in the mutant lines under elevated CO2 . Moreover, mutant lines produced much less seeds than wild-type plants regardless of CO2 concentration, demonstrating that NAD+ compartmentalization is …
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Mechanisms driving the expansion and progression of splicing factor-mutant clonal haematopoiesis
… key proteins within the tricarboxylic acid (TCA) cycle and electron transport chain (ETC) in SF3B1-mutant cells. This was associated with decreased aerobic metabolism and the accumulation of TCA cycle intermediates such as 2-oxoglutarate and the oncometabolite 2-hydroxyglutarate (2HG), which …
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Toxicity and biotransformation of 1,1,1,3,3-Pentafluoropropane, 3,3,3-Trifluoropropionic acid and 1,1,1,3-Tetrachloropropane
… acid were confirmed in vitro as metabolic intermediates, following biotransformation of 1,1,1,3,3-pentafluoropropane by the cytochrome P-450-system. Studies, designed for clarifying the cardiotoxicity of 1,1,1,3,3-pentafluoropropane were driven by the hypothesis that …