Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 3 of 3 for “"TBX4"”.
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Development of Vessels, Airways and Cartilage Rings: The role of T-box genes
Tbx4 and Tbx5 are two closely related genes that belong to the T-box family of transcription factor genes. Loss of Tbx4 results in absence of chorio-allantoic fusion and a failure of formation of the primary vascular plexus of the allantois leading to embryonic death at E10.5. Using a candidate …
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Studying the Effect of TBX4 Loss-of-Function on Postnatal Lung Development and How it Predisposes to Pulmonary Hypertension
… relationship with PAH, including T-box 4 (TBX4). Genetic predisposition may also contribute to group 3 PH, also known as PH due to chronic lung disease or hypoxia. Heterozygous pathogenic variants within TBX4 have been reported in cases from both PH groups. Therefore, the diagnosis and …
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Deep forward and reverse phenotyping for genetic discovery in pulmonary arterial hypertension.
… with a new candidate gene, COL6A5. While BMPR2, TBX4, EIF2AK4, ACVRL1 and AQP1 showed the highest association (PP≥0.99), I also confirmed significant associations in the majority of other previously identified genes. High impact variants in the KDR were associated with a significantly reduced KCO …