Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 17 of 17 for “"TBX3"”.
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The Role of TBX3 In Early Breast Cancer Progression
TBX3 is a transcriptional regulator involved in embryonic development and in tumorigenesis of several cancer types. There are two isoforms of TBX3 (TBX3iso1 and TBX3iso2) with different DNA binding domains. The large-scale functional roles of TBX3iso1 and TBX3iso2 were characterized in a breast …
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Regulation of the cyclin-dependent kinase inhibitor p21 by TBX3
TBX3, a member of the T-box family of transcription factors, is essential in development and has emerged as an important player in the oncogenic process. It is vital for the development of the heart, breasts, limbs, teeth and genitalia and TBX3 mutations lead to Ulnar-Mammary Syndrome, which is …
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The role of T-box transcription factor TBX3 in rhabdomyosarcoma
… the overexpression of the T - box factor TBX3, has been reported to function in promoting immortalization, migration, invasion and tumour formation in a number of epithelial - derived malignancies. Furthermore, our laboratory recently reported that TB X3 is also overexpressed in a wide …
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The Expression of T-Box (Tbx3) in the Bovine Mammary Gland
… factor (IGF)-I and T-box (Tbx)2 and 3. Tbx2 and Tbx3 are transcription factors required for mammary gland development in humans and known to regulate cell cycle. In addition, there is recent evidence that GH increases expression of Tbx3 in osteoblasts independent of IGF-I. Based on these …
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The c-Myc/TBX3/nucleolin/Hsc70 signalling axis in breast cancer
The T-box transcription factor TBX3, plays critical roles in development including the formation of the limbs, heart and mammary glands. While haploinsufficiency of TBX3 results in ulnar mammary syndrome, its overexpression is linked to several cancers. We and others have shown that TBX3 drives …
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A tumour suppressor role for the T-box transcription factor TBX3 in fibroblasts
TBX3, a member of the developmentally important T-box transcription factor family, has been shown to be overexpressed and to behave as an oncogene in several cancers. Much of this work has, however, been performed in carcinomas of epithelial origin and little is known about the role ofTBX3 in …
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The regulation of the T-box transcription factor TBX3 in Luminal A breast cancer
… To this end, the T-box transcription factor, TBX3, has been validated as a potential therapeutic target in breast cancer. TBX3 plays an important role in embryonic development including in the formation of several structures such as the heart, mammary glands, limbs, and lungs. Indeed, …
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The effect of seminal fluid on TBx2 and TBX3 expression and activity in cervical cancer cells
… to be elucidated. We hypothesized that TBX2 and TBX3, two highly homologous transcription factors frequently implicated in other cancers, may be responsible for mediating some of the effects of SF on cervical cancer cells. We established that TBX3 protein is significantly overexpressed in both …
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An investigation into the role of TBX3 in breast carcinogenesis and its regulation by the TGF-?1 signalling pathway
… to treat cancer. For example, the T-box factor TBX3 is overexpressed in a number of cancers including breast cancer but the mechanism(s) responsible for this upregulation as well as the precise role of TBX3 in the progression of this disease still need to be elucidated. This study provides novel …
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Defining the potential of HDAC5 and HDAC9 as therapeutic targets for Parkinson’s disease
… of the T-box 3 transcription factor (TBX3). Gene expression analysis found high expression of TBX3 in the adult SN relative to other brain regions, and gene co-expression analysis found a positive correlation of TBX3 with genes associated with a number of biological pathways and …
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Genetic Control Of Enteric Nervous System Development And Subtype Specification
… 2). Mice with an ENS-specific deletion of Tbx3 had reduced glia density (Chapter 3), and reduced density of a subtype of enteric neurons (Chapter 4). To determine if Dlx1, Dlx2, and Tbx3 were expressed in subsets of enteric neurons, we performed single-cell and single-nucleus sequencing on …
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Studying the Role of Mechanical Properties of Cancer Cells in Tumour Detachment, Migration and Secondary Tumour Formation
… with Western blotting and the oncogenic factor TBX3 was assessed with immunofluorescence techniques. The results show that melanoma progression led to decreased stiffness of cells in isolation in 2D, but increased cell stiffness in 3D. For cells in clusters, stiffness was similar across disease …
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Identifying novel drugs for the treatment of rhabdomyosarcoma
… to negatively regulate the oncogenic TBX2 and TBX3 transcription factors that are known drivers of RMS. The binuclear palladacycle, AJ-5, was recently shown to exert potent cytotoxicity in melanoma and breast cancer and to present with negligible adverse effects in mice. To investigate the …
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Identification of signalling pathways regulating TBX2 gene expression and its target genes
… cancer. Importantly, the T-box factors Tbx2 and Tbx3 are overexpressed in several cancers including melanoma, small cell lung carcinoma, breast, pancreatic, liver and bladder cancers and can suppress senescence, a cellular process which serves as a barrier to cancer development. However, the …
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Regulation of the anti-senescence factor, TBX2, by the UV stress signaling pathway and the mitotic cyclin dependent kinases
… the highly related T-box factors, Tbx2 and Tbx3, can suppress senescence through repressing the cyclin dependent kinase inhibitors, p21wAF11 c1 P118011 and p19ARF. Both Tbx2 and Tbx3 have also been linked to several cancers primarily because their expression levels have been found to be …
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Regulation of the anti-senescence factor, TBX2, by the UV stress signalling pathway and the mitotic cyclin dependent kinases
… the highly related T-box factors, Tbx2 and Tbx3, can suppress senescence through repressing the cyclin dependent kinase inhibitors, p21wAF11 c1P118011 and p19ARF. Both Tbx2 and Tbx3 have also been linked to several cancers primarily because their expression levels have been found to be …
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Effect of Cellular Positional Identity on Bone Regenerative Capacity for Tissue Engineering
… highly expressed in calvarial cells, whereas Tbx3 expression was elevated in femoral cells. Expression of the osteoblast-associated genes Bglap and Sppl were elevated in femoral cells, and also associated with increased osteopontin secretion and bone nodule formation. Runx2 was elevated in …