Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"TBK-1"”.
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BIOCHEMICAL CHARACTERIZATION OF SUPPRESSOR OF IKK-ε AND NAK-ASSOCIATED PROTEIN 1
… Hetero-interactions form between the kinase TBK-1 and NAP 255 and also TBK-1 and SIKE 72. TBK-1 shows a higher preference for binding NAP 255 in the prescence of both NAP 255 and SIKE 72. This work provides methodology to produce recombinant material for two components of the TLR3:interferon …
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Characterization of the anti-inflammatory effects of the Molluscum Contagiosum MC159 protein
… phosphorylation and subsequent activation of the TBK-1 kinase that in turn phosphorylates the Interferon Regulatory Factor-3 (IRF-3) transcription factor. I hypothesized that MC159 inhibits IFN-β protein synthesis. In support of this hypothesis, I found that MC159 inhibits IFN- β production in an …
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HIJACKING OF CELLULAR PATHWAYS BY NOVEL TICK-BORNE PHLEBOVIRUS
… infection leads to the reduction of RIG-I and TBK-1 expression, which were recovered when the Ubiquitin-Proteasomal Pathway was inhibited using MG-132. Lastly, we observed that mutation of ubiquitination sites of RIG-I and TBK-1 prevented and reduced the interaction with SFTS virus NSs, …
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NEW INSIGHTS INTO THE MOLECULAR PATHOGENESIS OF SEVERE FEVER WITH THROMBOCYTOPENIA SYNDROME VIRUS
… RIG-I and other signaling components, including TBK-1, was hypothesized, we found minimal change in the total protein levels of these host factors. However, in the presence of proteasomal inhibitors, an abrogation in the formation of virally induced vesicles was observed. This abrogation resulted …
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Influenza A virus infection and innate immunity in an established murine alveolar-like macrophage model
… is dependent on viral RNA replication, utilising TBK-1 and IRF-3 signalling to induce an antiviral state and viral killing. This late response also seems to play a role in resolving the ‘early’ responses to prevent the cytokine storm associated with severe uncontrolled response. The complexity and …