Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 3 of 3 for “"TBE-31"”.
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The Effects of Acetylenic Tricyclic Bis-(Cyano Enone) on Cell Migration
… The acetylenic tricyclic bis-(cyano enone), TBE-31, has been shown to be a promising chemopreventative compound. However, its effects on cell migration are unknown. This thesis focuses on deciphering the molecular mechanisms TBE-31 utilizes to inhibit cell migration. I demonstrated that …
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Investigating the role of the Nrf2-Keap1 pathway in mitophagy
… or high dose of the electrophilic cyanoenone, TBE-31, which modifies cysteine sensors in Keap1) correlated with a reduction in the levels of PINK1. The implications of these findings are not fully understood and further investigation is necessary.
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Regulation of transcription factors NRF2 and HSF1 in mediating cellular stress responses
… concentrations, the tricyclic cyanoenone TBE-31 strongly suppresses LPS-induced inflammatory responses in primary PMφ cells, suggesting the potential for therapeutic use in inflammatory diseases. <br/><br/>Another cytoprotective response is the heat shock response (HSR) which is activated …