Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"TB-IRIS"”.
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Differential proteomic profiling towards elucidation of TB-IRIS pathogenesis
Background Up to 59% of tuberculosis (TB)/human immunodeficiency virus (HIV) co-treated patients develop paradoxical TB-associated immune reconstitution inflammatory syndrome (TB-IRIS) after addition of antiretroviral (ARV) therapy to anti-tuberculous therapy (ATT). The course can be prolonged and …
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High throughput proteomic analysis of Mycobacterium tuberculosis associated Immune Reconstitution Inflammatory Syndrome (TB-IRIS)
Includes abstract. Includes bibliographical references.
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Histological evidence and clinical Correlations of renal TB-IRIS in HIV-positive patients and outcomes
… immune reconstitution inflammatory syndrome [TBCIRIS] is a well described clinical entity in HIV-infected patients that can affect multiple organs. There is however a paucity of information regarding renal involvement. This study aimed to illustrate the clinical, biochemical and …
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Modulation of protein expression in Mycobacterium tuberculosis-stimulated TB- IRIS patient-derived PBMCs by omega n-3 polyunsaturated fatty acids
… immune reconstitution inflammatory syndrome (TB-IRIS) is an inflammatory disorder which affects up to 54% of TB-HIV co-infected patients. Its pathogenesis remains unclear, and although treatment with the corticosteroid prednisone has shown some benefits, there is no specific treatment …
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Prolonged tuberculosis-associated immune reconstitution inflammatory syndrome: characteristics and risk factors
… immune reconstitution inflammatory syndrome (IRIS), the clinical course of IRIS is prolonged necessitating substantial health care utilization for diagnostic and therapeutic interventions. This phenomenon has not been systematically studied to date. We aimed to determine the proportion of …
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Investigating the molecular pathogenesis of tuberculosis-associated immune reconstitution inflammatory syndrome
… immune reconstitution inflammatory syndrome (TB-IRIS). Paradoxical TB-IRIS is an aberrant immune response targeted against Mycobacterium tuberculosis or its residual antigens in patients with advanced human immunodeficiency virus (HIV) infection shortly after commencement of antiretroviral …
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The immunomodulatory role of prednisone in patients with HIV-associated tuberculosis and assessment of its impact on lung function outcome
… immune reconstitution inflammatory syndrome (TB-IRIS). I do this using data collected during the PredART trial. This randomized, double-blind, placebo-controlled trial showed that a 28-day course of prophylactic prednisone in adult patients identified as being at high risk for paradoxical …
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Immunological characterization of the HIV-tuberculosis associated immune reconstitution inflammatory syndrome
While the integration of anti-TB and cART therapies is associated with substantial clinical improvement in the majority of patients, HIV-Tuberculosis associated Immune Reconstitution Inflammatory Syndrome (TB-IRIS) has been shown to occur in a significant subset of these patients. TB-IRIS is an …
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Diagnosis, treatment and immunopathogenesis of the HIV-associated tuberculosis immune reconstitution inflammatory syndrome
… immune reconstitution inflammatory syndrome (TB-IRIS) is a frequent complication of antiretroviral therapy (ART) among patients who start ART while on treatment for tuberculosis (TB). The condition manifests with new, worsening or recurrent inflammatory features of TB due to immunopathology …
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Investigations into HIV-associated tuberculous meningitis
[Background] Tuberculous meningitis (TBM) is a common form of tuberculosis in high TB incidence settings. However, the burden of disease and outcome in affected adults is unknown in Cape Town. The diagnosis of TBM is often challenging, particularly in HIV co-infected patients and no standardized …
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A retrospective review of Granulomatous Interstitial Nephritis (GIN) amongst HIV-infected patients at Groote Schuur Hospital, Cape Town
… radiological evaluation and search for positive TB cultures was performed. Patients were divided according to the likely aetiology of GIN, ranging from least to most likely TB-GIN, together with the likelihood of a druginduced or ascending infection-related aetiology. Mortality data was obtained …