Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 98 for “"TB treatment"”.
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TB or Not TB: Treatment of Latent Tuberculosis Infection in Harlem, New York
… States have latent tuberculosis infection (LTBI) and are therefore at risk for progression to active disease. Diagnosis and treatment for LTBI has been identified by the Centers for Disease Control and Prevention (CDC) and the Institute of Medicine as a major strategy for elimination of …
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Performance of host blood transcriptomic signatures for TB diagnosis and monitoring TB treatment
… tests are necessary to enable tuberculosis (TB) diagnosis and monitoring of TB treatment. This work aimed to identify which published blood transcriptomic TB signatures have the best diagnostic performance to distinguish between TB cases and other respiratory diseases (ORDs) in symptomatic …
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Genetic and pharmacokinetics factors associated with susceptibility to kanamycin induced cochleotoxicity in a cohort of patients undergoing MDR/RR-TB treatment
… of multidrug-resistant tuberculosis (MDR-TB) and rifampicin resistance tuberculosis (RR-TB). The standard MDR/RR-TB regimen prescribed in South Africa, at the time of the present study included Kanamycin, an aminoglycoside with a known cochleotoxic effect. Although kanamycin has recently …
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Baseline prevalence and incidence and risk factors for new-onset drug induced hearing loss in adults receiving drug-resistant tuberculosis (DR-TB) treatment in Khayelitsha, South Africa
Treatment for drug-resistant tuberculosis (DR-TB) is longer and associated with more significant side-effects than drug susceptible TB. Second line injectable therapy using kanamycin, amikacin or capreomycin is associated with irreversible hearing loss. There is a scarcity of literature regarding …
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Biomarkers and cell phenotypes in TB patients with minimal or persisting lung inflammation post-anti-TB treatment and ex-vivo atorvastatin immunomodulatory effects on M. tuberculosis-infected PBMC
Unresolved lung inflammation post-anti-TB treatment necessitates the evaluation of additional host-directed therapies (HDT). Statins, recognized for their pleiotropic effects, show potential as immunomodulators to reduce post-TB lung inflammation. The ongoing StatinTB clinical trial utilizes a …
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Factors associated with non-adherence to anti-tuberculosis treatment in the Vhembe District, South Africa
Background: Failure to adhere TB patients to tuberculosis therapy is a major challenge that challenges the efforts to eradicate tuberculosis. While ground-breaking approaches have been introduced to reduce the number of people who are unable to finish their prescribed TB drugs, there is still quite …
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Burden of antituberculosis and antiretroviral drug-induced liver injury at a secondary hospital in South Africa
… the proportion of patients who present with TB treatment and or ART-associated drug-induced liver injury (DILI) amongst all patients presenting with significant liver injury to GF Jooste Hospital during the study period. 2. To describe base line clinical characteristics and management of TB …
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Pharmacogenetic analysis of admc polymorphisms affecting the efficacy of TB treatment in tuberculosis patients from Tanzania and Uganda, and pharmalogical evaluation of potent medicinal plant extracts used in the treatment of tuberculosis
… of antibiotics which can cure tuberculosis (TB), it remains the leading cause of death from a single infectious disease worldwide. Recent research has shown that the way anti-tuberculous drugs are processed by the body (pharmacokinetics) and their effects on the disease (pharmacodynamics) …
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Characterization and quantification of urinary metabolic biomarkers for early response to anti-tuberculosis treatment
Development of new anti-tuberculosis (TB) therapies remains a major priority to combat this infectious disease and to prevent continued transmission of the causative agent Mycobacterium tuberculosis (Mtb). However, newly developed therapies require large, lengthy clinical trials to determine the …
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Factors influencing non-adeherence to tuberculosis treatment in TB/HIV co-infected adults at the University Teaching Hospital,Lusaka,Zambia
Zambia is a high TB/HIV prevalence country. The aim of this study was to explore barriers to TB treatment adherence and determine the prevalence of non-adherence in the Zambian capital of Lusaka. The factors under study were socio-economic and demographic, service-related and disease and treatment …
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The impact of undernutrition on tuberculosis prevalence and treatment outcomes in Ethiopia
Introduction: Tuberculosis (TB) is a leading infectious cause of death globally, with an estimated 10.6 million new cases and 1.3 million deaths annually. The emergence of multidrug-resistant tuberculosis (MDR-TB), characterized by resistance to isoniazid and rifampicin, further complicates the …
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The impact of undernutrition on tuberculosis prevalence and treatment outcomes in Ethiopia
Introduction: Tuberculosis (TB) is a leading infectious cause of death globally, with an estimated 10.6 million new cases and 1.3 million deaths annually. The emergence of multidrug-resistant tuberculosis (MDR-TB), characterized by resistance to isoniazid and rifampicin, further complicates the …
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Effect of rifampicin-based antitubercular therapy on nevirapine plasma concentrations in South African adults with HIV-associated tuberculosis
… immunodeficiency virus (HIV) and tuberculosis (TB) infection. Non-nucleoside reverse-transcriptase inhibitor (NNRTI)-based antiretroviral therapy (ART) is recommended for first-line treatment in adult HIV treatment programmes in resource-limited settings [1]. Many South African HIV-infected …
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Transcriptomic signatures of recurrent tuberculosis disease and treatment response in HIV-infected individuals
… are at particularly high risk of tuberculosis (TB) disease, especially in TB endemic countries where M. tuberculosis transmission is common. Although antiretroviral therapy (ART) reduces risk of TB, it does not return to that of HIV-uninfected persons. In addition, a previous history of TB …
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Design of a large-dose minimally invasive drug delivery device for Tuberculosis
Tuberculosis (TB) affects millions of people all over the world, and in India has an incidence figure of about 2.8 million individuals annually. The TB treatment regime is quite involved, generally requiring six months and multiple medications. A lack of medication adherence can lead to …
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Assessment of knowledge, perceptions and beliefs related to tuberculosis in the rural, communities of Vhembe District in Limpopo Province
… perceptions, and health beliefs related to TB among people in the rural communities of Vhembe District in Limpopo Province. The research design was qualitative, descriptive and exploratory in nature. The study was conducted amongst the rural communities at Xigalo and Kurhuleni villages in …
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Early morning urine collection to improve the sensitivity of LAM in hospitalised TB/HIV co-infected patients
… lipoarabinomannan (LAM) is a low-cost rapid TB diagnostic for use in HIV co-infected patients. However, its sensitivity in these patients is suboptimal. Strategies to improve its performance is a need. The hypothesis was that early morning urine (EMU), rather than random urine sampling, would …
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Does the inclusion of the cost and burden of adverse drug reactions associated with drug-resistant TB treatment affect the incremental cost-effectiveness of new treatment regimens? A case study from the introduction of bedaquiline in South Africa National TB Programme
… Africa has one of the world’s highest burdens of TB, HIV/TB co-infection, and drug-resistant TB. Second-line TB treatment is less effective, more expensive, and more toxic than treatment for drug-sensitive TB. Nearly 1 in every 5 persons who starts treatment for drug-resistant TB in South Africa …
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Developing methods to prioritize in vitro drug combinations against Mycobacterium tuberculosis: fusidic acid as potential combination partner with known antitubercular agents
The tuberculosis (TB) epidemic remains a major threat to public health globally, and is exacerbated by the escalating number of multi-drug resistant cases. These factors have highlighted the urgent need for new effective therapies or different approaches to augment the efficacy of current anti-TB …
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Rifampicin-resistant tuberculosis in Botswana: barriers and risk factors influencing patient outcomes, case detection, and linkage to effective care and treatment
Background: Botswana reports high treatment success for rifampicin-resistant tuberculosis (RR-TB), but many challenges remain. Case detection is lower than expected and varies by year, and mortality rates are high. Research aims included identifying: factors associated with mortality, access to …
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