Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 854 for “"TB"”.
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Immunoproteome of anti-TB drug associated DRESS in HIV TB co-infection
… immunoproteomic profile of DRESS to first-line TB drugs in HIV infected cases. We hypothesize that differentially regulated proteins would be found interindividually and with disease evolution that may provide a mechanistic understanding of DRESS underlying pathways. Participants and Methods: …
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TB or Not TB: Treatment of Latent Tuberculosis Infection in Harlem, New York
… States have latent tuberculosis infection (LTBI) and are therefore at risk for progression to active disease. Diagnosis and treatment for LTBI has been identified by the Centers for Disease Control and Prevention (CDC) and the Institute of Medicine as a major strategy for elimination of …
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Performance of host blood transcriptomic signatures for TB diagnosis and monitoring TB treatment
… tests are necessary to enable tuberculosis (TB) diagnosis and monitoring of TB treatment. This work aimed to identify which published blood transcriptomic TB signatures have the best diagnostic performance to distinguish between TB cases and other respiratory diseases (ORDs) in symptomatic …
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The transciptomic landscape of HIV-TB
… of this thesis I provide a broad overview of HIVTB with an emphasis on systems approaches followed by an overview of a systems-level study aiming at addressing hypotheses relating to transcriptional differences in active tuberculosis and HIV-1 infection, measured in blood and the site of disease …
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Influence of HIV, smoking and hyperglycaemia on the reporting of TB symptoms in a TB prevalence survey
… through door-to-door community surveys using a TB symptom-screening questionnaire, and is an economical and practical tool to employ in poor, high burden areas. However, unlike for the high risk group of people infected with HIV, there is a lack of evidence supporting the adaptation of a symptom …
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'You must tune your TB programme well...' : integrating TB, HIV and ARV care in Cape Town primary care setting
… crisis: the prevalent HIV and tubertulosis (TB) co-epidemic, the concern that antiretroviral (ARV) provision might compromise the existing TB control programme, and that the Western Cape's current limited vertical model of ARV roll-out will soon reach capacity. This study evaluated whether …
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The development of aptamer-based probes for the detection of TB antigens ESAT-6.CFP-10 potential TB diagnostic tools
Lack of point-of-care (PoC) diagnostic tools for TB hinders control of the disease, particularly in resource-limited, high HIV and TB prevalence countries. Therefore, there is a need for simple, rapid, accurate, and affordable PoC diagnostics to detect active TB early enough for opportune …
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Evaluation of the costs of managing cutaneous adverse drug reactions to first-line TB therapy in South African TB patients
Background: Optimal tuberculosis (TB) treatment remains the backbone of effective TB control programmes. However, TB drugs are often associated with adverse drug reactions (ADR) that affect treatment adherence and cure. Cutaneous adverse drug reactions (CADR) are more commonly associated with Human …
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Comparing the risk of Tuberculosis (TB) infection in the households with and without TB patients in Tsumkwe constituency, Otjozondjupa region, Namibia
… in northern Namibia are heavily burdened by the TB disease partly due to high household density. This study compares the risk of transmission of TB among close contacts with the community contacts. A retrospective cohort study was conducted and data, of index cases registered during 2014 and …
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The impact of isoniazid preventative therapy and antiretroviral therapy on tuberculosis (TB) in HIV-infected children in a high TB incidence setting
… therapy] and ART [antiretroviral therapy] on TB incidence in HIV-infected children. A cohort analysis will be performed using data from a prospective, double-blinded placebo controlled trial of INH versus placebo in HIV-infected children in Cape Town, South Africa.
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Characterising the immunometabolic profile of HIV/TB co-infection
… virus (HIV) and Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB) during co-infection of a host is well established. While this synergy is driven by immunological deterioration, the metabolic mechanisms that contribute to the associated disease burden experienced …
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Differential proteomic profiling towards elucidation of TB-IRIS pathogenesis
Background Up to 59% of tuberculosis (TB)/human immunodeficiency virus (HIV) co-treated patients develop paradoxical TB-associated immune reconstitution inflammatory syndrome (TB-IRIS) after addition of antiretroviral (ARV) therapy to anti-tuberculous therapy (ATT). The course can be prolonged and …
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Systematic review of the association and dose-response and relationship between silica exposure or silicosis, and risk of TB disease and TB mortality
Includes abstract. Includes bibliographical references.
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Optical pulse processing towards Tb/s high-speed photonic systems
Due to the continued growth of high-bandwidth services provided by the internet, there is a requirement to operate individual line rates in excess of 100 Gb/s in next generation optical communications systems. Thus, to implement these high-speed optical networks all-optical processing techniques …
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Computer aided diagnosis of miliary TB in chest X-rays
… an aid to the radiologist in diagnosing miliary TB. Some statistical approaches and template matching methods were used to measure characteristics of both healthy and unhealthy (miliary TB) lung textures. These measurements were evaluated to see if a computer can be programmed to differentiate …
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The biochemical and molecular characterisation of respiratory mucins in TB
… South Africa, specifically the Western Cape, TB has wreaked havoc especially amongst those of the lower socioeconomic groups. However, despite the prevalence of the disease in South Africa and the known morbidity and mortality associated with mucus and mucin hypersecretion in respiratory …
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Association between BCG-induced immunity and risk of TB disease
We tested the hypothesis that a lower frequency and profile of specific T cells induced by BCG vaccination at birth is associated with subsequent risk of developing tuberculosis.
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Consumptive Cape Town : the Chapel Street TB clinic, 1941-1964
… focuses on the history of the Chapel Street TB Clinic and Administration Centre in Cape Town from 1941 to 1964. The author set out to evaluate the Cape Town City Council's attempts to control the TB epidemic, through the lens of the Chapel Street TB Clinic, in order to provide a local …
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Investigating the socio-economic and epidemiological risk factors associated with TB transmission in a high TB and HIV burdened community in Cape Town, South Africa
… biological factors such as HIV-status with TB transmission or clustering, our understanding of the associations between TB transmission and socio-economic risk factors for TB remains incomplete. More studies are required to enhance our understanding, and hence inform targeted interventions …
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TB-RBP protein : sitting at the crossroads of sex and disease
… was to determine the crystal structure of TB-RBP (Testis/Brain RNA binding protein) in complex with single stranded DNA. The secondary goal was to determine the crystal structure of TB-RBP in complex with Trax (translin associated factor X). Functions of TB-RBP is to suppresses translation …
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