Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 52 for “"TAZ"”.
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The TAZ Protein Interactome in Striated Muscle
… characterized the Hippo transcriptional effector TAZ as a repressor of the myogenic differentiation program. Without DNA-binding ability, TAZ function exclusively depends on its protein:protein interaction network. This prompted us to undertake a proteomic-based study aimed at identifying the TAZ …
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Defining mechanisms directing YAP/TAZ-mediated tumorigenesis
… co-activator with PDZ binding motif (TAZ) (YAP/TAZ). Uncontrolled nuclear YAP/TAZ activity evokes tumor-initiating properties in a range of epithelial-derived cancers, including oral and breast cancers, but their downstream targets and mechanisms of action are unclear. Recent studies …
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Molecular Consequences of High Taz Expression In Gliomas
… has identified the transcriptional co-activator TAZ (WWTR1) as a major driver of the MES transition. Overexpression of this single protein in glioma stem cells has been shown to drive a transition from a PN to MES cell state. In this study, we explore in depth the consequences of high TAZ …
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Biophysical profiling of YAP/TAZ dependent mechanical responses
… transcriptional co-activators, YAP and TAZ, play prominent roles in proliferation, regeneration, and wound healing. Interestingly, these are often found to be dysregulated in aged tissue. Yet, the precise mechanisms of YAP/TAZ regulation on cellular responses in an ageing niche remain …
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Identifying the Molecular Mechanism of TAZ-Induced Lung Tumorigenesis
… co-activator with PDZ-binding domain (TAZ) is a transcriptional co-activator and downstream component of the tumor suppressor Hippo pathway that plays critical roles in organ size control, stem cell self-renewal, tumorigenesis and drug resistance. Recently, TAZ has been identified as a …
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UNRAVELING TAZ REGULATION IN BREAST CANCER BY CRISPR SCREENING
YAP and TAZ are transcriptional coactivators belonging to the Hippo signaling pathway. Their activity is regulated by a complex network of upstream signals. As consequence, they orchestrate a wide spectrum of downstream cellular responses. In physiological conditions, a precisely balanced …
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YAP/TAZ REGULATES ALVEOLAR REGENERATION AND RESOLUTION OF LUNG INFLAMMATION
… with increased nuclear expression of Yap and Taz, the mediators of the Hippo pathway. Mice that lacked Yap/Taz in AECIIs exhibited prolonged inflammatory responses in the lung and were delayed in
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YAP and TAZ have Functionally Redundant Roles in Uveal Melanoma
… experiments revealed the presence of nuclear Taz in the yap null tumors. Our data suggest that this reflects functional redundancy between yap and its paralog, taz, either of which can efficiently drive UM. Furthermore, we show that the tumorigenic effects of YAP and TAZ are TEAD-dependent. To …
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The Role of YAP/TAZ in von Willebrand Factor Gene Expression
… with higher synthesis in venous regions. YAP and TAZ are paralogous coactivators largely known for their role in the Hippo pathway. They function predominantly through interactions with TEAD transcription factors to regulate transcription of target genes, which ultimately execute the physiological …
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Yap and Taz Are Required For Neural Crest-Derived Cardiovascular Development
… during embryogenesis. <em>Yap </em>and <em>Taz </em>are downstream effectors of the fundamental Hippo signaling pathway and are vital for proper organ and tissue development, yet their role in neural crest (NC)-derived heart formation is still largely unknown. We generated <em>Yap </em>and …
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Vinexin regulates autophagy through YAP/TAZ: implications for health and disease
… on the transcriptional coactivators YAP and TAZ. The rationale here is: 1. YAP/TAZ activity is implicated in autophagy, 2. YAP/TAZ and vinexin are both linked to HCC. My data show that YAP/TAZ transcriptional activity is upregulated upon vinexin depletion. Moreover, increased autophagy …
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Establishment of MITF and TAZ as major determinants of uveal melanoma
… model, but resulting tumors display active TAZ, a YAP paralog. Moreover, we establish that TAZ is an extremely potent oncogene in UM using autochthonous zebrafish models, even moreso than YAP. Furthermore, we show that higher TAZ expression, but not YAP expression, significantly correlates …
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Taz As A Regulator of Mesenchymal Transformation and Clinical Aggressiveness In Gliomas
… co-activator with PDZ-binding motif (TAZ) to be highly associated with the mesenchymal shift. High TAZ expression correlated with worse clinical outcome and higher grade. These data led to the <strong>hypothesis</strong> that TAZ is critical to the mesenchymal transition and aggressive …
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Phenotypic screening and AI uncovers modulators of YAP and TAZ activity in glioblastoma
… pathway transcriptional coactivators YAP and TAZ are master regulators of up to 70% of the entire glioma stem cell gene signature and so represent key molecular targets in the development of new therapeutic strategies for GBM. However, targeting these transcription cofactors in the context of …
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Combinatorial Roles Of Skeletal Cell Yap And Taz In Bone Growth, Remodeling, And Repair
… co-activator with PDZ-binding motif (TAZ) in bone are controversial, with evidence for each either promoting or inhibiting osteogenesis in vitro. Here, we used in vivo mouse models of combinatorial YAP/TAZ deletion from skeletal lineage cells to investigate their physiologic roles in …
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Preliminary Study on How Tumor Suppressor Nf2 Inhibits Transcriptional Coactivators Yap/Taz in the Developing Mouse Brain
… effectors, transcriptional coactivators Yap/Taz. The molecular mechanism of how Nf2 regulates Yap/Taz is not understood. Here I showed that Nf2 regulated the Yap/Taz activity by decreasing the stability of Yap/Taz. The regulation was independent of Yap-S366 phosphorylation, which is required …
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Papel de YAP/TAZ en la respuesta de células tumorales a estímulos activadores de receptores de TRAIL
… rigidez. Los reguladores transcripcionales YAP y TAZ son los principales responsables de la detección de su grado de rigidez. En una matriz extracelular laxa, ambos factores permanecen inactivos en el citoplasma; sin embargo, cuando la matriz se vuelve más rígida, YAP/TAZ se translocan al núcleo. …
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The Role of the Discoidin Domain Receptor-1 (DDR1) in Vascular Smooth Muscle Cell (VSMC) Mechanosensing
… genes is mediated by a DDR1-YAP/TAZ nuclear complex. Ddr1-/- VSMCs had reduced nuclear YAP/TAZ, and loss of YAP/TAZ resulted in decreased DDR1 expression. DDR1 activation and increased substrate stiffness promoted DDR1 and YAP/TAZ nuclear localization. DDR1 and YAP/TAZ nuclear …
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Identification and Characterization of the TGFβ/Hippo Crosstalk through Mathematical Modeling
… interconnected. Hippo pathway mediators Taz/Yap interact with the TGFβ regulated Smads and when Hippo is activated, the cytoplasmically localized Taz/Yap reduces or prevents Smad nuclear accumulation thereby dampening TGFβ induced transcriptional activity. In the nucleus, Taz/Yap can …
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