Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 3 of 3 for “"TAR DNA-binding protein of 43 KDa (TDP-43)"”.
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A molecular analysis of the relation between TDP-43 and tau pathology
Tau is a microtubule associated protein found in inclusions in tauopathies including Alzheimer's disease. One known cause of neurodegeneration is an excess of exon 10 inclusion in tau mRNA which is caused by several mutations in the MAPT gene, encoding tau. Processing of the Amyloid Precursor …
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Dynamic changes of TDP-43 in testicular and epididymal sperm
TAR DNA-binding protein of 43 kDa (TDP-43) is a ubiquitously expressed and evolutionarily conserved protein. TDP-43 is a DNA/RNA binding protein with several functions such as gene transcription, mRNA splicing and stability, transposon silencing, and micro RNA biogenesis. TDP-43 is associated with …
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THE INTERPLAY BETWEEN THE PROTEIN QUALITY CONTROL SYSTEM AND EXTRACELLULAR VESICLES IN THE DISPOSAL OF DISEASE-ASSOCIATED PROTEINS AND MIRNAS IN ALS AND FTD MODELS
… characterized by the presence within neurons of toxic cytoplasmic inclusions containing the insoluble forms of the TAR DNA-binding protein of 43 KDa (TDP-43) and its C-terminal fragments (CTFs) of 35 (TDP-35) and 25 KDa (TDP-25). The accumulation of TDP-43 into insoluble cytoplasmic aggregates …