Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"TAR DNA-binding protein 43"”.
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Exploring the Mitigation of TDP-43 Toxicity by Sis1 in Yeast
… there is no cure. Research has revealed that Tar DNA-binding Protein 43 cytoplasmic aggregates are involved in many cases of Amyotrophic Lateral Sclerosis. One possible mechanism for TDP-43 induced toxicity is that these aggregates are titrating away a molecular chaperone protein, Sis1, from …
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TDP-43 Is Directed to Stress Granules by Sorbitol, a Novel Physiological Osmotic and Oxidative Stressor
TDP-43, or TAR DNA-binding protein 43, is a pathological marker of a spectrum of neurodegenerative disorders including amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration with ubiquitin-positive inclusions (FTLD-U). TDP-43 is an RNA/DNA-binding protein implicated in …
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Characterization of a Phosphomimetic Mutant of the ALS Associated Protein TDP-43
<p>Trans-activation response (TAR) DNA-binding protein 43 (TDP-43) is a natively dimeric 414-residue protein that is encoded by the human <em>TARDBP</em> gene that has important implications in the pathogenesis of the neurodegenerative disorders ALS, FTD, and CTE. TDP-43 has been found …
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Characterization of Codon Optimized Wild Type TDP-43 Mediated Neurodegeneration in a Drosophila Model for ALS.
TAR DNA Binding Protein-43 (TDP-43) is known to mediate neurodegeneration associated with amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration-ubiquitin (FTLD-U). The exact mechanism by which TDP-43 exerts toxicity in patient brains remains unclear. In a Drosophila model, we …
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Old-age hippocampal sclerosis in the aged population
… it has been associated with both ischaemia and TAR-DNA-binding protein-43 (TDP-43)-related neurodegeneration. Variations in genes GRN, TMEM106B and ABCC9 are proposed as HS risk factors. The aim of this thesis was to investigate epidemiological, clinical, pathological and genetic characteristics …
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Characterization of the Dimerization and Salt Dependent Aggregation of the ALS-Linked Protein TDP-43
<p>Trans-active response (TAR) DNA-binding protein 43 (TDP-43) is essential for RNA processing but can also form toxic cytoplasmic inclusions in neurons of patients with amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD). RNA-binding has been shown to have the …
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Of Sex, Gut and Brain: Functional Studies in a Mouse Model of Amyotrophic Lateral Sclerosis-Frontotemporal Dementia
… dimorphism is also evident in a mutant human TAR DNA binding protein 43 (TDP43) mouse model of ALS-FTD, whereby males have a much shorter lifespan than females. Interestingly, these mice exhibit an abnormally enlarged gut, suggesting an involvement of the gut microbiota (i.e., the collective …
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Identification and characterization of a pathological TDP-43 variant in amyotrophic lateral sclerosis and frontotemporal lobar degeneration
TAR DNA-binding protein 43 (TDP-43) proteinopathy is a key pathological feature of a majority of amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD) cases. One key feature of pathological TDP-43 is the presence of lower molecular weight (MW) C-terminal species of 25 and …
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AGGREGATION MECHANISMS OF TDP-43 PROTEIN IN RESPONSE TO STRESS IN AMYOTROPHIC LATERAL SCLEROSIS AND THERAPEUTIC APPROACHES
… present in 97% of ALS cases, consists in TDP- 43 proteinopathy characterized by the accumulation of ubiquitinated and phosphorylated TAR DNA-binding protein 43 (TDP-43) in the cytoplasm, accompanied by the concomitant loss of TDP-43 splicing activity in the nucleus of affected neurons. The …
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Commonalities between SMA and ALS: investigation of ribosome heterogeneity and translational defects
… and their association with different proteins, known as ribosome-associated proteins (RAPs). In particular, these proteins can exert a direct role on mRNA selection and translation efficiency. At present, some RNA-binding proteins (RBPs), such as Fragile X Messenger Ribonucleoprotein 1 …
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CRISPR-based approaches for proteinopathies of the central nervous system
Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2026-05-01