Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"TAPBPR"”.
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Characterisation of TAPBPR in immune cells
… More recently, a second peptide editor, named TAPBPR, was discovered. Together, they shape the MHC-I presented peptidome. However, unlike its homologue tapasin, TAPBPR catalyses peptide exchange independently of the PLC. It works closely with UDP-glucose: glycoprotein glucosyltransferase 1 …
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Exploiting the Molecular Mechanisms of TAPBPR for use in Cancer Immunotherapy
TAPBPR is a chaperone within the MHC-I antigen processing and presentation pathway, responsible for shaping the immunopeptidome via MHC-I peptide editing and the recycling of sub-optimally loaded MHC-I to the peptide loading complex. As such, TAPBPR plays an essential role in the activation of the …
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Molecular basis of TAPBPR-mediated peptide editing on MHC class I molecules
… two intracellular peptide editors, tapasin and TAPBPR. TAPBPR was shown to shape the peptide repertoire presented on MHC class I at the cell surface, either by directly catalysing peptide exchange on MHC class I molecules or by associating with the quality control enzyme UDP-glycoprotein …
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Utilising recombinant TAPBPR technology to investigate MHC class I peptide editing and therapeutic applications
… and presentation pathway. In this pathway, TAPBPR shapes the presented peptidome by catalysing peptide exchange on MHC-I molecules and promoting the recycling of sub-optimally loaded MHC-I molecules to the peptide loading complex. TAPBPR has been shown to preferentially bind to and exchange …
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Characterising the immunopeptidome in hepatitis B
… molecules tapasin and tapasin-related molecule TAPBPR optimize the peptide repertoire presented on HLA class I on the cell surface. TAPBPR is involved in both loading optimal peptides and preventing sub-optimal peptides from loading (filtering) and has been shown to restrict the peptide …
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Senescence and the Innate Immune System
… cirrhosis. Tapasin and tapasin related protein (TAPBPR), both parts of the antigen presentation pathway are expressed in liver tissue and show a slight upregulation in liver disease. This suggests that aberrant expression via this pathway may be part of the liver pathology. In summary there is …