Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"TANK binding kinase 1"”.
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Developing Novel Therapies Targeting the Tumor Microenvironment of Aggressive Breast Cancer
… to identify novel synergy targets. We found TANK-binding kinase 1 (TBK1) to be the top therapeutic candidate due to its critical role in immune responses. Strikingly, combined suppression of AXL and TBK1 significantly reduces IBC and TNBC growth in vitro and in vivo by modulating the …
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THE ACTIVATION, RECEPTOR COMPLEXING AND ENDOGENOUS REGULATION OF THE TYPE-I INTERFERON RESPONSE AS IT PERTAINS TO INNATE IMMUNITY
… Critical to this pathway is the activation of a kinase, TANK binding kinase 1 (TBK1), which phosphorylates the downstream transcription factors, IRF3 and IRF7, and leads to the production of IFN-beta. Interestingly, TBK1 function has been implicated in a number of other signaling cascades ranging …
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Loss of TBK1 Kinase Function Improves Disease Outcome in Pancreatic Cancer and Metabolic Syndrome
Aberrant expression and activity of TANK binding kinase 1 (TBK1) has been observed in numerous diseases. Here I've identified novel functions for TBK1 in pancreatic ductal adenocarcinoma (PDA) and in metabolic syndrome that promote disease progression. Activating mutations in KRAS are present in …
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The Sec6/8 (a.k.a. Exocyst) Complex Supports DNA Repair Fidelity
… pathway through the innate immune protein TBK1 (TANK-binding kinase 1). siRNA-mediated depletion of TBK1 in pancreatic and breast cancer cell lines results in apoptosis, which is mediated through the AKT pathway. Pharmacological inhibition of TBK1 recapitulates the apoptotic phenotype in mouse …
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The Non-canonical Function and Regulation of TBK1 in the Cell Cycle
Protein kinases play essential roles in orchestrating almost every step during mitosis. Aberrant kinase activity often leads to errors in the cell cycle progression which consequently becomes the underlying cause for developmental defects or abnormal cell proliferation leading to cancer. Tank …
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Identifying Protein Kinase Tbk1 As A Novel Inhibitor of Intestinal Tumorigenesis
… focuses on the study of a serine/threonine kinase, TANK Binding Kinase 1 (TBK1). Although TBK1 is best known as a mediator of type I interferon induction in antiviral innate immunity, recent evidence suggests the involvement of TBK1 in several other biological processes including cancer …