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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 50 for “"TAMs"”.
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Hs/tams Change Procedures in South-Central Illinois: An Evaluative Study
Made available in DSpace on 2014-12-10T18:48:33Z (GMT). No. of bitstreams: 1 7514116.pdf: 8133672 bytes, checksum: 2ef190c1b7378eb855c446608c0b6c80 (MD5) Previous issue date: 1975
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Calibration system for the Tracking Accuracy Measurement System (TAMS) using differential GPS (dGPS)
… dissertation. The Tracking Accuracy Measurement (TAMS) was designed to exploit the positional accuracy of differential Global Positioning System (dGPS) technology to qualify a 60km range X-band combined Optronic and Radar Tracker System. In essence, a roving GPS receiver, capable of measuring high …
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Seismic investigations of the northern Transantarctic Mountains
… of ~4500 m, the Transantarctic Mountains (TAMs) are the largest non-compressional mountain chain on Earth. The TAMs show no evidence of folding or reverse faulting as is typically seen in contractional mountain building, calling the origin of the mountain range into question. Using data …
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STUDY OF THE EFFECT OF TUMOUR EDUCATED MACROPHAGES ON NEURAL CELLS
… hypothesised that Tumour-associated macrophages (TAMs), a distinctive cell type within the tumour microenvironment, could represent an innovative therapeutic approach for neuro-regenerative medicine. Indeed, TAMs possess a unique set of properties, including immune suppression, extracellular …
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Dissecting the Role of Hedgehog Signaling in Tumor-associated Macrophages and Immunosuppression in the Tumor Microenvironment
… These M2 polarized tumor-associated macrophages (TAMs) are known to suppress immune responses and promote neoplastic progression. We sought to gain insights into the regulation of TAM functions and mechanisms by which TAMs exert immunosuppressive changes within the tumor microenvironment …
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Tumor-assoziierte Mikroglia und Makrophagen modellieren durch GPNMB das Tumorwachstum und die Immunzellinfiltration in malignen Gliomen
… microglia and blood-derived macrophages (TAMs) play a central role in modulating the immune suppressive microenvironment in glioma. Here, we show that GPNMB is predominantly expressed by TAMs in human glioblastoma multiforme and the murine RCAS-PDGFb high grade glioma model. Loss of GPNMB …
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Determining the upper mantle seismic structure beneath the northern transantarctic mountains, Antarctica, form regional p- and s-wave tomography
… up to 4,500 m, the Transantarctic Mountains (TAMs) are the largest non-compressional continental mountain range on Earth and represent a tectonic boundary between the East Antarctica (EA) craton and the West Antarctic Rift System. The origin and uplift mechanism associated with the TAMs is …
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The impact of Wnt5a signaling and tumor associated macrophages in breast cancer
… tissue damage. Tumor associated macrophages (TAMs) have many features in common with M2 macrophages; they are anti-inflammatory and have a weak tumoricidal capacity. We show that Wnt5a induces an anti-inflammatory tolerogenic macrophage phenotype in a pro-inflammatory environment and we could …
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Discovery of novel transaminases from halophilic microorganisms
… hydrolases, lyases, oxidases and transaminases(TAms). TAms are PLP-dependent enzymes which catalyse the transfer of an a minegroup from an a minedonor toaketoneoraldehyde,resulting in a chiralamine. Their use has been successfully applied to the synthesis of chiral amines for active …
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Targeting and Reprogramming Tumor-Associated Macrophages with Polymeric Nanoparticle-Mediated mRNA Delivery for Cancer Treatment
… (TME), where tumor-associated macrophages (TAMs) play a key role. TAMs can be divided into pro-inflammatory M1 type macrophages and anti-inflammatory M2 type macrophages. Reprogramming TAMs from an M2-type to an M1-type is considered a promising cancer therapy.Chimeric antigen receptor …
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Crosstalk between colorectal cancer cells and tumour-associated macrophages
… behaviour. These tumour-associated macrophages (TAMs) were of the M2 phenotype (CD206+). In CRC patient tissues and xenografts from mouse model, presence of increased amount of M2 macrophages was observed. M2 macrophages derived from human monocyte cell line THP-1 secreted high levels of IL-8 and …
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MCP-1, Macrophages and Tumorigenesis in the C3(1)/Sv40Tag Mouse Model of Breast Cancer: Benefits of Quercetin
… accumulation of tumor associated macrophages (TAMs). TAMs enhance mammary tumor growth by promoting chronic inflammation, tumor cell invasion, angiogenesis and metastasis. Quercetin is a flavonol present in several plant based foods with anti-inflammatory, anti-obesogenic and anti-carcinogenic …
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Investigation of the Structure of Alkyne Self-Assembled Monolayers on Gold and the Development of Matrix-Enhanced Secondary Ion Mass Spectrometry Methods
… characterization of terminal alkyne monolayers: TAMs) adsorbed on gold was investigated by RAIRS, single wavelength ellipsometry, time-of-flight secondary ion mass spectrometry: TOF SIMS) and x-ray photoelectron spectroscopy: XPS). TAMs have the potential to transform surface functionalization …
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The role of tumor-associated macrophages in pancreatic cancer
… metastasis. Tumor-associated macrophages (TAMs) are essential components of the tumor microenvironment (TME) and play essential roles in the regulation of tumor progression and immunity. In recent years, macrophage-targeted monotherapy or integrated therapies have been investigated in …
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Tumor-Derived Retinoic Acid Regulates Intratumoral Monocyte Differentiation To Promote Immune Suppression
… immunosuppressive tumor associated macrophages (TAMs) but not immunostimulatory dendritic cells (DCs) remains unclear. Using multiple murine sarcoma models, we found that the TME induced tumor cells to produce retinoic acid (RA), which polarized intratumoral monocyte differentiation towards TAMs …
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CD68-positive tumour associated macrophages, PD-L1 expression, and EBV latent infection in a high HIV-prevalent South African cohort of Hodgkin lymphoma patients
… of CD68-positive tumour associated macrophages (TAMs) has been associated with poorer outcomes in HIV-negative patients with Hodgkin lymphoma (HL), but whether this is true in HIV positive patients with HL is not known. In this study, we investigated the number of CD68-positive TAMs and …
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Investigating the spatiotemporal dynamics of mononuclear phagocytes in solid tumours.
… of rapidly replenished, monocyte-derived (md)TAMs that are enriched at the tumour core from resident-like (r)TAMs that interact with fibroblasts at the tumour-normal interface. Upon tumour infiltration, mdTAMs differentiate along two divergent fate trajectories, distinguished by the expression …
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Establishing a Mouse Model of Glioblastoma (GBM) And Developing Strategies to Eliminate Cancer Cells.
… help study curcumin-mediated repolarization of TAMs and recruitment of NK cells to eliminate GBM. Additionally, we attempted to develop CA-CC adducts to achieve repolarization of TAMs and eliminate chemoresistance in the GBM cells.</p>
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JAG1 Blockade With oHSV Polarizes Macrophages to Create a Unique Vulnerability for Cetuximab-Mediated Senolysis of Glioma Cells
… glioma cells and tumor-associated macrophages (TAMs), and its expression correlated with a worse prognosis, we engineered a JAG1-antagonizing oHSV (OncoD-0J1) and interrogated its impact on the tumor and myeloid TME. OncoD-0J1 antagonized JAG1-mediated Notch signaling and had a significant …
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