Global ETD Search
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Showing 1 to 2 of 2 for “"TAK-779"”.
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Dynamics of HIV coreceptors and their utilization by plasma and cerebrospinal fluid HIV-1 isolates
… to in vitro inhibition by CCR5 antagonists TAK-779 and Maraviroc (MVC). V3 envelope polymorphisms, recently related to reduced virologic response to MVC in clinical trials, were displayed in some of the least susceptible isolates. The results provide theoretical support for an early …
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Recombinant CXCR4/CCR5 hybrid receptors as tools for studies of HIV-1 receptor usage
… resistance to inhibition by the CCR5 antagonist TAK-779. In conclusion, our findings propose that alterations in the mode of CCR5 use may be a key event in R5 virus pathogenesis. We believe that R5 virus ability to utilize these CXCR4/CCR5 chimeric receptors reflects a more flexible and more …