Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 20 for “"TADs"”.
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A Study of the Relationship between Borderline-dysregulated Personality and Treatment-resistant Depression in the Course of the TADS Randomised Controlled Trial
… course of the Tavistock Adult Depression Study (TADS). The TADS was a randomised controlled trial comparing Long Term Psychodynamic Psychotherapy (LTPP) to Treatment as Usual (TAU) for 129 patients whose depression has not been successfully treated by at least two previous interventions. The …
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STABILITY OF TEMPORARY ANCHORAGE DEVICES IN VARYING PORCINE BONE DENSITIES
… Orthodontists place Temporary Anchorage Devices (TADs) in all parts, guided by bone porosity and intra-oral location. These decisions may influence TAD stability, defined as the amount of interlocking between the TAD and bone immediately after insertion. The aim of the study was to evaluate the …
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Orthodontic Treatment of Anterior Open-bite With and Without Skeletal Anchorage
… appears to be mounting evidence of benefits that TADs may offer in treatment of anterior open bite (AOB), there remains a lack of studies comparing outcomes and stability in patients treated with and without skeletal anchorage in growing versus non-growing individuals. The purpose of this study is …
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UNCOVERING STRUCTURE-FUNCTION RELATIONSHIPS IN CHROMATIN ARCHITECTURE
… feature of Topological Associating Domains (TADs) and their inner subTADs in high resolution Chromosome-Conformation-Capture Hi-C data. We then apply our method to chromatin dynamics during mitosis, uncovering how TADs and subTADs evolve temporally. Afterwards, we classify TADs/subTADs by the …
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Asssessing the Liquid-Liquid Phase Separation Abilities of Eyes Absent Protein
… Despite wide sequence variation in human EYA1-4 TADs, with approximately 40% identity conserved vs. 77% identity conserved in the ED, all four EYA TADs were identified as potential drivers of liquid-liquid phase separation in a proteome-wide screen. The apparent conservation of this physical …
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Identificación y caracterización de elementos regulatorios distales controlados por TGFβ
… de los TRDs está restringida por los bordes de TADs, causando un sesgo hacia la corregulación dentro de los TADs. To better understand how TGFβ-dependent enhancers control gene transcription in epithelial cells, we performed a comprehensive analysis of enhancers in normal mammary epithelial …
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Characterizing 3D epigenomes in pathological conditions
… within topologically associating domains (TADs). Notably, a targeted depletion of the cohesin complex within TADs points to a potential interference with loop extrusion processes by the infection. Accompanying these structural and epigenome disturbances is the compromising of …
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Unfolding genome organization in interphase
… topologically associating domains (TADs) which are believed to function as coherent gene regulatory neighborhoods. However, the mechanisms driving these patterns are still unknown. In this thesis, I describe and apply computational methods that test the predictions of a recently …
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Insights into transcriptional regulation from natural and induced variation in closely related species
… of topologically associating domains (TADs). TADs make up a level of the 3D genome organisation that dictates formation of regulatory landscapes. Although it is known that CTCF plays an important role in TAD formation, evidence of TAD boundaries being robust to CTCF depletion …
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Bimaxillary Protrusion in Trinidad and Tobago Population: Prevalence, Features and Management
… <br/>The use of Temporary Anchorage Devices (TADs) showed shorter treatment time in bimaxillary protrusion cases. There is however low quality evidence that TADs could be the preferred method for anchorage for bimaxillary protrusion cases.<br/><br/>The cephalometric norms for this population …
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Ta Da! - The Text Adventure Design Assistant a Visual Tool for the Development of Adventure Games
… languages for creating text adventure games, TADS and Inform, are compared and contrasted, and my abstract framework is adapted to both of these languages. The traditional pencil-and-paper design process used by adventure game authors is studied and its application to the development of TA DA! …
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The Nucleosome Remodelling & Deacetylase complex: Genome folding & transcriptional regulation
… compartments, topologically associating domains (TADs) and chromatin loops mediated by key architectural proteins such as CTCF and Cohesin. It has further been used to establish physical models of gene regulation such as loop extrusion. Chromatin remodeling protein complexes - complexes that can …
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The interplay of global chromosomal organisation, promoter-enhancer interactions and transcription
… including Topologically Associating Domains (TADs). In parallel, high-resolution versions of these technologies (such as 5C, CHiA-PET, HiChIP and Capture Hi-C) have detected multitudes of novel looping interactions, including connections between promoters and enhancers. The interplay between …
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Changes of nucleosome positioning and 3D chromatin organization in cell transitions
… DNA such as topologically associating domains (TADs) which serve to insulate some loci from the rest of the genome. A major determinant of the chromatin domain boundaries is the architectural protein CTCF that binds to thousands of locations in the genome and changes the chromatin configuration …
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3D chromosome structure and chromatin proteomics
… shown to form topologically associating domains (TADs) and insulated neighborhoods, which were mostly preserved in the transition between naive and primed states. Insulated neighborhoods are critical for proper gene expression, and their disruption leads to the improper regulation of local gene …
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Batf regulates previously unknown AP-1 target genes to control TH17 differentiation
… defined transcriptional activation domains: TADs), some consist only of a basic region and leucine zipper and are thought to function as inhibitors of AP-1 activity. We found that the AP-1 protein Batf, which lacks a TAD, is highly expressed in T helper cells compared to various other immune …
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The chromatin landscape of colorectal cancer cells
… loops and topologically associating domains (TADs) compartmentalize genomic loci and their corresponding molecular transcriptional elements in three-dimensional space. Transcription of the human genome is proximity-dependent requiring the cooperative engagement of non-coding elements and …
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The 3d Genome As A New Dimension In Understanding Pathologic Short Tandem Repeat Instability
… termed topologically associating domains (TADs) and subTADs and (2) repeat expansion in the FMR1 gene, the genetic driver for Fragile X Syndrome, results in grossly mis-wired genome folding genome-wide and at the boundary encompassing the FMR1 gene in a manner that correlates with …
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ENERGY FLOW AND MACROINVERTEBRATE PRODUCTION IN PANAMANIAN HIGHLAND STREAMS: ASSESSING THE IMPACTS OF AMPHIBIAN DECLINES
… of the Tropical Amphibian Declines in Streams (TADS) project, I quantified major energy fluxes, secondary production, and macroinvertebrate community structure for two consecutive years in four stream reaches in the Panamanian uplands, two with healthy amphibian populations and two that had …
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Characterization of Boundary Element-Associated Factors BEAF-32A and BEAF-32B and Identification of Novel Interaction Partners in Drosophila Melanogaster
Regulatory elements are DNA sequences which have specialized activities that coordinate the functions of the genome. Promoters, enhancers, locus control regions, boundary elements (or insulator elements) are examples of DNA sequences that have regulatory properties. In transgenic assays insulator …