Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"TACC3"”.
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Structural Characterization and Chemical Inhibition of the ARNT/TACC3 Complex
… coactivators (coiled-coil coactivators: TACC3, TRIP230, CoCoA), involved in cancer development and progression. Normally, these coactivators play an essential role in the HIF hypoxia response, directly interacting with the ARNT subunit of HIF in a novel and promoter-specific way. However, …
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Discovery and Elucidation of The Fgfr3-Tacc3 Recurrent Fusion In Glioblastoma
… coiled-coil containing protein 3 </em>(<em>TACC3</em>) gene in glioblastoma multiforme. The fusion occurred in 8.3% of patient samples, but not in low grade or normal samples. <em>FGFR3-TACC3 </em>produced an in-frame fusion protein that promoted an oncogenic phenotype both <em>in vitro</em> …
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Development of a Neoepitope Prioritization Platform to Identify Immunogenic Neoantigens from Oncogenic FGFR3-TACC3 Fusion in Glioblastoma
This study investigates the FGFR3-TACC3 fusion as a tumor-specific neoantigen source and establishes an end-to-end computational and experimental framework for the identification, prioritization, and validation of immunogenic neoantigens derived from chimeric RNAs. The FGFR3-TACC3 fusion, generated …
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DECIPHERING THE FUNCTION OF HURP IN REGULATING MICROTUBULE DYNAMICS AND CHROMOSOME MOVEMENT
… and kinetochore capture. HURP interacts with TACC3 in vivo and in vitro. Depletion of HURP abolishes the localization of TACC3 around the chromosome region along the spindle, so that the formation of kinetochore microtubule is impeded. The defect in kinetochore microtubule formation results in …
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CHARACTERISATION OF A NOVEL SPINDLE DOMAIN IN MAMMALIAN MEIOSIS
… identified additional components of the MSPD. TACC3, under the regulation of Aurora-A at aMTOCs, drive assembly of the MSPD. This domain was absent in MTOC free human oocytes but a second population of TACC3 (identified in mouse oocytes) localised to the meiotic spindle and K-fibres was …