Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"TAC1"”.
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EXPRESSION OF SUBSTANCE P IN BRAINSTEMS OF VICTIMS OF SUDDEN UNEXPLAINED PERINATAL DEATH
… and to see the evolutionary aspects of SP gene (TAC1) through computational analysis. Immunohistochemistry demonstrated SP-immunoreactivity in correspondence of the caudal trigeminal nucleus area, with progressive increase in density of positive fibers of the corresponding tract from fetal life …
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Transcriptional Regulation of Azole Antifungal Resistance in Candida albicans
… regulated by a zinc cluster transcription factor Tac1p. A gain-of-function mutation in the gene encoding this transcription factor is responsible for the overexpression of CDR1 and CDR2. To identify the Tac1p regulon, we analyzed four matched sets of clinical isolates with gain-of-function …
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The aetiology of pain in chronic midportion Achilles tendinopathy
… genes: COMT rs4818 (C/G), COMT rs4633 (C/T), TAC1rs2072100 (C/T), TACR1 rs3771829 (C/G) and SCN9A rs6746030 (G/A) were selected based on the biological function of their encoded proteins within the pain pathways. The objectives of the specific chapters which addressed these aims were: • …
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Characterisation of L-cell secretory mechanisms and colonic enteroendocrine cell subpopulations
… EC cells distinguished by Piezo2 and Tac1 expression, respectively and a third Sct-expressing group. Immunofluorescent labelling and RT-qPCR analysis revealed that the Nts-expressing and Insl5-expressing L-cell subpopulations are proximally and distally enriched in the murine colon, …
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Investigation of Clinically Relevant Fluconazole Resistance Mechanisms in the Fungal Pathogen Candida parapsilosis
… Gain-of-function polymorphisms in MRR1 and TAC1 have been shown to elevate the expression of MDR1 and CDR1/CDR2 respectively and directly contribute to fluconazole resistance in Candida albicans. Our lab previously identified three resistant isolates with upregulated CpMDR1 expression that …
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An Investigation into Clinically Relevant Determinants of Azole Resistance in Candida albicans
… Increased CDR1 expression in isolates lacking TAC1 gain-of-function mutations coupled with recent literature suggesting a role of the Mrr2 zinc cluster transcription factor in azole resistance lead us to sequence and test mutations in the MRR2 gene in across this collection. By placing mutant …