Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"TAB1"”.
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An investigation of the activation of protein kinase complexes in the MyD88 signalling network
… chains to the TAB2 or TAB3 components of the TAB1-TAK1-TAB2 and TAB1-TAK1-TAB3 complexes. In the second part of the thesis I tested whether this broadly accepted model was correct by knocking out the genes encoding TAK1 and its regulatory subunits TAB1, TAB2 and TAB3 by CRISPR/Cas9 …
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The Role of Tak1 In Pancreatic Cancer Development
… of TAK1 is caused by its binding partner TAB1. Knocking down of TAK1 in pancreatic cancer cells with RNAi technique resulted in cell apoptosis and significantly reduces the size of tumors in mice and made a chemotherapy drug more potent. Targeting the kinase activity of TAK1 with the …
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Maintenance of fetal membrane integrity by cyclic cellular transitions during gestation and parturition
… (TGF-β), TGF-β activated kinase binding protein (TAB1), and p38 mitogen-activated protein kinase (p38 MAPK) signaling in human and mice membranes. This process is balanced during gestation by progesterone (P4) which transitions ‘reservoir’ stromal AMCs into epithelial cells (MET) through its …
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The Association Between The Il-1 Pathway
… MEK3, MEK6, JNK, P38, c-JUN, ECSIT, TRAF6, TAB1, TAK1, RKIP, NIK, IKKα, IKKβ, IκBα, and NF-κB.</p> <p>The individual SNP analysis proved to be interesting though inconclusive. There were some borderline significant results, such as associations of the SNPs rs16944, rs1143627, rs1071676, and …