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Showing 1 to 13 of 13 for “"T4SS"”.
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Characterization of The Role of The Pkm101-Encoded T4Ss Outer Membrane Core Complex In Substrate Transfer, Pilus Biogenesis, and Recipient Cell Contact
<p>The bacterial type IV secretion systems (T4SS) encoded on the <em>Escherichia coli</em> pKM101 and R388 conjugative plasmids and the <em>Agrobacterium tumefaciens</em> <em>virB</em> operon are composed of 12 subunits arranged in an architecturally similar fashion. Structural studies of the T4SS …
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Development of Chimeric Type Iv Secretion Systems For Transfer of Heterologous Substrates Across The Gram-Negative Cell Envelope
<p>Many bacteria use Type IV Secretion Systems (T4SSs) to aid in pathogenesis by translocating virulence factors across the cell envelope and into eukaryotic cells. These systems are structurally and functionally diverse, but are often compared to the archetypal VirB/VirD4 T4SS of <em>Agrobacterium …
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Characterization of The Agrobacterium Tumefaciens Virb2 Pilin of The Virb/D4 Type Iv Secretion System
… VirB/D4 type IV secretion system (T4SS) delivers oncogenic T-DNA and effector proteins to susceptible plant cells. This leads to the formation of tumors termed Crown Galls. The VirB/D4 T4SS is comprised of 12 subunits (VirB1 to VirB11 and VirD4), which assemble to form two …
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Assessing Helicobacter pylori's HcpE and DsbK's Effects on Immunostimulation in Host Gastric Cells
… via the Type-IV-Secretion-System-(T4SS), identify candidate host interacting partners and the subcellular localization of HcpE within host cells. AGS (adenocarcinoma gastric) cells were exposed to either live bacteria, bacterial culture supernatants, outer membrane vesicles (OMVs), …
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Helicobacter pylori Type 4 Secretion System Modulates Host T Cell Responses
… H. pylori requires its type 4 secretion system (T4SS) translocated components: effector protein CagA and cell-wall peptidoglycan (PG) fragments for up-regulating B7-H1 as well as B7-H3, and for down-regulating B7-H2 on GEC. These data were validated in vivo by using a mouse model of infection. My …
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Immunogenität translozierter Effektorproteine bei Infektionen mit Bartonella henselae
… in welche sie durch ein Typ IV-Sekretionssystem (T4SS) transloziert wurden. Das achte Protein (17kDa) ist Teil dieses T4SS. <br>Es wurden 116 Seren von Patienten mit gesicherter Katzenkratzkrankheit und 110 IFT-negative Kontrollseren auf Antikörper gegen BepA – BepG und das 17kDa-Antigen getestet. …
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Specificity and benefits of an exclusion mechanism for a mobile genetic element in Bacillus subtilis
… transfer through Type 4 Secretion Systems (T4SSs) encoded in the ICE DNA, however unlike plasmids, ICEs are usually found integrated into the host chromosome except for immediately prior to, during and after conjugative transfer. Almost all plasmids and some ICEs have an exclusion mechanism, …
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<em>Agrobacterium</em> Virb10 Contributions to Type Iv Substrate Secretion, T-Pilus Biogenesis, and Outer Membrane Pore Formation
The VirB/D4 type IV secretion system (T4SS) of <em>Agrobacterium tumefaciens</em> functions to transfer substrates to infected plant cells through assembly of a translocation channel and a surface structure termed a T-pilus. This thesis is focused on identifying contributions of VirB10 to substrate …
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Evasion Of Innate Immunity By The Pathogen Coxiella Burnetii
… Q fever. It uses a type IV secretion system (T4SS) to inject over 100 bacterial effector proteins into the host cytoplasm, which modulate many host cellular processes to form a replicative niche for the bacteria inside the cell. We describe here the discovery of a bacterial effector that …
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Structural Studies of the Receiver Domain of LytR from Staphylococcus Aureus and Interaction Studies of TraW and TrbC from the F Plasmid of Escherichia Coli
… system (TCS) and the type IV secretion system (T4SS). Microbes use TCSs to regulate important functions such as sporulation, chemotaxis, as well as autolysis that leads to biofilm formation. In addition, microbes utilize T4SSs to deliver DNA, protein substrates, toxin, and virulence factors, …
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Genome analysis of Campylobacter concisus strains from patients with inflammatory bowel disease and gastroenteritis
… genomospecies. Both islands were found to carry T4SS homologous proteins and a number of putative effector proteins similar to known pathogen effector proteins were identified. These results suggest that the two novel C. concisus genomic islands are likely to be involved in C. concisus virulence. …
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The Role of Mammalian Lipid Transport Protein ORP1 During Coxiella Burnetii Infection
… (CCV) and uses a Type 4B secretion system (T4SS) to secrete effector proteins into the host cell cytoplasm. While the CCV membrane is rich in sterols, cholesterol accumulation in the CCV is bacteriolytic, suggesting that C. burnetii regulation of lipid transport is critical for infection. …
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Caractérisation des systèmes d'exclusion des plasmides conjugatifs IncC
La dissémination de résistance à de multiples antibiotiques est un enjeu majeur de santé publique. Ce phénomène est notamment dû à la conjugaison bactérienne, qui permet la transmission d’ADN entre deux bactéries présentes dans le même milieu, même entre espèces qui peuvent être phylogénétiquement …