Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 182 for “"T2D"”.
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A RANDOMIZED STUDY OF THE GLUNOVO REAL-TIME CGM EFFECTIVENESS ON METABOLIC CONTROL IN PATIENTS WITH T2D
… with poorly controlled type 2 diabetes (T2D) compared to traditional self-monitoring of blood glucose (SMBG). Research Design and Methods: This prospective, open-label, randomized controlled trial included 178 patients with T2D from the Fatebenefratelli-Sacco Hospital in Milan. …
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Studies in beta cells and adipocytes in the context of obesity and T2D - focusing on PDE3B, OPN and SCFAs
Type 2 diabetes (T2D) is a heterogeneous disease characterized by altered lipid parameters and elevated glucose levels, as a direct consequence of impaired insulin signaling in target tissues and reduced insulin exocytosis from pancreatic β-cells. Obesity, which dramatically increases worldwide, is …
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Genetic and functional investigation of sequence variation associated with the related phenotypes: birth weight, obesity, and type 2 diabetes (T2D)
… Global incidence of obesity and Type 2 diabetes (T2D) has increased rapidly in the last fifty years and even more rapidly in immigrant ethnic minority communities in Western countries. There is evidence of a connection between birth weight and the subsequent risk of obesity and T2D in adulthood, …
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Comparing and contrasting healthcare professionals’ and patients’ perceptions, understanding and experiences of Type 2 Diabetes (T2D) and its management: A qualitative study.
… increased prevalence of Type 2 Diabetes (T2D) in the UK has seen the adoption of empowerment models of T2D management. Research exists which contrasts patients’ and healthcare professionals’ perspectives of T2D management. However, no studies explicitly contrast healthcare professionals’ …
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GENETIC AND BIOCHEMICAL ANALYSIS OF TYPE 2 DIABETES AND DIABETIC COMPLICATIONS
… (9.3%) are affected by type 2 diabetes (T2D). T2D is characterized by the body not producing enough insulin and not responding to the insulin that it does produce resulting in high blood glucose. Common complications associated with T2D include cardiovascular disease (CVD), nephropathy or …
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Genetics of Type 2 Diabetes and Metabolic Syndrome: From Genome Wide Linkage Scan and Candidate Genes to Genome Wide Association Studies
Type 2 diabetes (T2D) and metabolic syndrome (MetS) are major health problems associated with cardiovascular disease. Both diseases are influenced by a combination of genetic and environmental factors. The aim of this thesis was to identify genetic risk factors for T2D, particularly T2D associated …
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Genetic and molecular characterisation of metabolic subphenotypes and their contribution to type 2 diabetes aetiology
… of the genetic architecture of type 2 diabetes (T2D) has allowed the identification of hundreds of genetic loci contributing to T2D risk. However, understanding how these loci contribute to the aetiological complexity of T2D has been more challenging. Using an interdisciplinary approach this …
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A multi-ancestry genetic analysis of type 2 diabetes
… global health expenditures. Type 2 diabetes (T2D) comprises ~90% of diabetes cases, is characterised by pancreatic islet beta cell dysfunction and reduced insulin response in insulin-sensitive tissues, and is associated with a myriad of risk factors, including diet, obesity, activity measures, …
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Meat consumption and type 2 diabetes: investigating heterogeneity and potential causal mechanisms
Type 2 diabetes (T2D) is a complex metabolic disease which affects more than 500 million people worldwide, imposing enormous burdens on affected individuals and their families, healthcare systems and societies. Healthy diets play a crucial role in preventing T2D and meat has been reported to be …
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Genetic and dietary determinants of Type 2 diabetes in a black South African population
Background: The increasing burden of T2D is a global cause of concern. However in Africa where the countries are ill equipped to manage this pandemic, the prevalence of T2D will increase the most by 2030 compared to other parts of the world. Urgent efforts are thus required to lessen the T2D …
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The Human Pancreatic Islet Methylome and Its Role in Type 2 Diabetes
… development and progression of type 2 diabetes (T2D). Epigenetic modifications are essential for establishing and maintaining cell identity and function in normal circumstances. Exposure to adverse environmental factors may alter the epigenome, and result in changes of gene expression and the …
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The association of physical activity with prediabetes/type 2 diabetes and cardiac autonomic function
… activity with prediabetes/type 2 diabetes (pre/T2D) and cardiac autonomic function. The purpose of study 1 was to examine whether using both objectively (accelerometer) and subjectively (questionnaire) measured moderate- to vigorous-intensity physical activity (MVPA) and sedentary time (SED) …
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Fraternity Personal Health, Inspiring Transformation (FRAT PHIT): Type 2 diabetes nutrition and physical activity behaviors among African American men
… disproportionately affected by type 2 diabetes (T2D). Effective T2D programs are those that recognize and leverage the protective benefits of brotherhoods or peer-to-peer networks of AA men. Previous researchers have engaged AA brotherhoods in T2D interventions, yet with focuses limited to …
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The Development of a New Theoretical Framework to Explore Type 2 Diabetes Self-Management Behaviours in UK South Asian Patients: Recommendations for Healthcare Practice.
Type 2 diabetes (T2D) is a significant public health concern with a high prevalence within the UK South Asian (SA) population. T2D is predominantly managed by lifestyle behaviours such as diet, exercise, medication and self-monitoring of blood glucose. Previous research has highlighted that SA …
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Evaluation of Genetic Variants Influencing Susceptibility to Type 2 Diabetes Associated End-Stage Kidney Disease and Associated Phenotypes
… 2 diabetes associated end-stage kidney disease (T2D-ESKD) and African ancestry. Incidence and prevalence of T2D-ESKD, in addition to non-diabetic forms of ESKD, are markedly higher in African Americans compared to all other ethnicities even after adjustment for socioeconomic factors. Familial …
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Genetic Variations in Type 2 Diabetes and Cardiovascular Disease: A Focus on Gene-Lifestyle Interactions and Mendelian Randomization
Type 2 diabetes (T2D) and cardiovascular disease (CVD) are highly prevalent complex diseases that result from lifestyle and genetic factors. Gene-lifestyle interactions are also believed to contribute to the etiology of these diseases. The aim of this thesis was to investigate gene-lifestyle …
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Mechanisms of insulin resistance and β - cell failure in type 2 diabetes. Effective diet against o minous octet
… intervence je pilířem léčby diabetu 2. typu (T2D). Vegetariánská strava je zajímavou alternativou. Cíle naší studie byly následující: 1. Porovnat účinky vegetariánské a konvenční diabetické diety se srovnatelnou kalorickou restrikcí na inzulínovou rezistenci, objem viscerálního tuku a …
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Evaluation of Practical Exercise Tools for People with Type 2 Diabetes: Resistance Bands and the MyWellness Key Accelerometer
… an important component of type 2 diabetes (T2D) management. Thesis objectives included: 1) determine the accuracy of the MyWellness Key (MWK) accelerometer in people with T2D; 2) complete a systematic review and meta-analysis of resistance band training (RBT) in T2D; and 3) propose and …
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The interplay between genes and dietary factors in the aetiology of Type 2 Diabetes Mellitus
… the escalating prevalence of Type 2 Diabetes (T2D) and alleviate society of its associated morbidity and economic burden on health care, it is crucial to understand its aetiology. Both genetic and the environmental risk factors are known to be involved. Healthy diets have been proven to reduce …
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Investigation of Genetic and Behavioural Determinants of Type 2 diabetes and Glycaemic Traits
Type 2 diabetes (T2D) is a complex chronic disease which is associated with micro- and macro-vascular complications and premature mortality. This multifactorial disease originates from a complex interplay between genetic, behavioural and environmental risk factors, the underlying mechanisms of …
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