Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 68 for “"T1D"”.
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Physical Activity, Heart Rate Variability, Sleep Parameters, and Glycemic Variability in T1D
Background: In individuals with type 1 diabetes (T1D), glycemic variability (GV), beyond mean glucose levels, is a critical determinant of cardiovascular risk and long-term complications. Although physical activity and sleep are key behavioral factors influencing glycemic control, prior research …
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Sociodemographic risk factors of glycemic control for youth with T1D: Cross-sectional and longitudinal patterns of HbA1c
… and diabetes care of youth with Type 1 Diabetes (T1D) over three years. IGC modeling allowed comparison of confounded sociodemographic predictors of disease outcomes that included ethnicity, SES, parent marital status, family structure, as well as disease duration, to determine the relative impact …
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The Impact of Depressive Symptoms on Healthcare Utilization and Charges for Adolescents with Type 1 Diabetes (T1D)
… $200 billion annually) and that type 1 diabetes (T1D) contributes a disproportionately large share to these costs, factors associated with higher costs in this population should be examined. The present study examines the impact of adolescent and maternal depressive symptoms on healthcare …
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Detection and characterisation of enteroviruses and the gut virome in islet autoimmunity and type 1 diabetes using novel molecular methods
Type 1 diabetes (T1D) is a chronic autoimmune condition affecting over 8.4 million individuals globally. Usually preceded by islet autoimmunity (IA), T1D results from a complex interplay between host genetics and environmental factors, with virus infections, especially enteroviruses (EV) identified …
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Genetic Loci Contributing to Spontaneous Autoimmune Diabetes
Background and Aims: Spontaneous type 1 diabetes (T1D) in the BioBreeding (BB) rat mimics human T1D as the rats experience weight loss, polydipsia, polyuria, ketoacidosis, onset during puberty and insulin-dependency within a day after diagnosis. Because the DP rat develops T1D spontaneously, it is …
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Genetic contribution to type 1 diabetes microvascular complications
Type 1 diabetes (T1D) is an autoimmune disease characterized by destruction of beta cells in the pancreas resulting in insulin deficiency, which leads to hyperglycemia and organ damage. T1D patients experience an increased risk of morbidity and mortality due to long-term complications, specifically …
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Type 1 diabetes in children - risk factors and prediction.
… important for development of Type 1 diabetes (T1D). Increased birth weight (BW), increased linear growth and gestational infections are among the reported risk factors. T1D is predictable by analysis of HLA genotypes and islet cell autoantibodies. In this thesis risk factors and prediction of …
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Aspects of autoantibody epitopes in type 1 diabetes
Type 1 diabetes (T1D) is strongly associated with autoantibodies against insulin (IAA), glutamic acid decarboxylase 65 (GADA), insulinoma-associated protein 2 (IA-2A) and the most recently identified zinc T8 transporter (ZnT8A). Together or alone, they are important both to predict T1D and to …
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The effects of aerobic and resistance exercise on inflammatory markers and metabolic control in healthy individuals and type 1 diabetics using either insulin pump or multiple dose injection
Type 1 diabetes (T1D) is characterised by an absolute insulin deficiency resulting from the chronic and progressive destruction of pancreatic β-cells by the immune system cells. Continuous subcutaneous insulin infusion (CSII) is becoming a popular technique for insulin delivery among T1D patients. …
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Effects of 5��-Dihydrotestosterone (DHT) on Mouse Gut Microbiome– A Study of Sex Differences and Hormonal Effects on Gut Microbiome Composition
<p>Type 1 Diabetes (T1D) is a polygenic and multifactorial disease, traditionally attributed to genetic susceptibility and diet. Over the past decade, novel studies have placed a higher significance on the role of gut microbiome in T1D pathogenesis. Furthermore, diabetic mouse models have shown …
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Microrna 21 targets B Cell Lymphoma 2 (Bcl2) Mrna to increase beta cell apoptosis and exosomal Microrna 21 could serve as a biomarker of developing Type 1 Diabetes Mellitus
The role of beta cell miR-21 in Type 1 Diabetes (T1D) pathophysiology has been controversial. Here, we sought to define the context of beta cell miR-21 upregulation in T1D and the phenotype of beta cell miR-21 overexpression through target identification. Furthermore, we sought to identify whether …
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Accelerating data-driven discovery in type 1 diabetes: an informatics-based approach
Type 1 diabetes (T1D) is a lifelong chronic disease characterized by the absolute or near-absolute loss of insulin. For affected individuals, management of T1D is an unremitting challenge that involves constant blood glucose monitoring and lifelong administration and titration of exogeneous …
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Joint whole exome sequencing and linkage analysis in a multigenerational family segregating Type 1 Diabetes
Backround: Type 1 diabetes (T1D) is a complex autoimmune disease with a strong familial segregation. On the other hand, the recent and rapid increase in incidence is a proof of the importance of environmental factor in the etiology of disease. Linkage and Genome-wide association studies had …
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Dose-Response Effects of Working Memory Training Among Adolescents with Type 1 Diabetes
Type 1 diabetes (T1D) is a chronic disease that is due to the dysregulation of glucose in the blood when insulin is not made endogenously. Patients rely on a combination of exogenic insulin, medications, blood glucose monitoring, and healthy lifestyle activities such as dietary control and exercise …
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Overwhelming responsibility : divorced mothers of children managing type 1 diabetes with their children
… may have challenges managing of type 1 diabetes (T1D) for their children. The purpose of this study was to examine the processes by which divorced mothers with children diagnosed with T1D manage the disease. Open-ended interviews were conducted with 12 mothers who collectively had 13 children with …
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Psychosocial screening in children and adolescents with type 1 diabetes
Management of Type 1 Diabetes (T1D) in children and adolescents is challenging. Psychological and social factors may explain why many young people fail to adequately control their diabetes. Research examining the potential benefits of introducing psychosocial screening into routine clinical care is …
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CELF1, PTBP1, and RBFOX2-mediated alternative splicing regulation in cardiovascular diseases
… (AS) is dysregulated in Type 1 diabetic (T1D) and hypoplastic left heart syndrome (HLHS) patient hearts but the mechanisms responsible are unclear. Here, we provide evidence that in these patient’s hearts that dysregulation of the RNA binding proteins (RBPs) CELF1, PTBP1, and RBFOX2 …
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The effects of a combined aerobic and resistance exercise programme on physiological parameters and metabolic control in type 1 and 2 diabetes
… the physiology and metabolic control in Type 1 (T1D) and Type 2 diabetes (T2D), using non-diabetic (ND) people as a control. The management and treatment of T1D and T2D volunteers were first assessed in surveys and the novelty was second to expose both to exercise. In the latter, volunteers were …
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Early life phenotypes of type 1 diabetes genetic risk
… shown that children who develop type 1 diabetes (T1D) have larger size at birth — a marker of foetal growth — or rapid postnatal weight gains. Recent studies have explored the contribution of the T1D susceptibility human leukocyte antigen (HLA) alleles, which explain half of disease heritability, …
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The Timing of Walking and Post-Meal Blood Sugar Levels in Adults with Type 1 Diabetes
… challenge for individuals with type 1 diabetes (T1D). This thesis examined whether, compared to being sedentary, a 20-minute moderate-intensity walk pre- or post-dinner could reduce postprandial glucose excursions. Eleven adults with T1D using hybrid closed-loop systems (HCLS) participated in …
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