Global ETD Search
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Showing 1 to 5 of 5 for “"T.brucei"”.
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Linkage mapping and genetic analysis of Trypanosoma brucei
Trypanosoma brucei is a protozoan parasite of major public health and economic importance in sub-Saharan Africa, where it is the causative agent of sleeping sickness in man and Nagana in cattle. The complete genome sequence of T.brucei is now available and the diploid genetic system has recently …
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Use of molecular and bioinformatics tools for developing methods of epidemiological identification of trypanosomes
… populations in Africa caused by the Trypanosoma brucei spp parasite. Although, the current number of the reported cases is on the decrease, more efforts are required to try to control or eliminate the disease. The recent advances in molecular techniques have contributed towards identifying …
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Mitochondrial ATP production and energy-buffering in the human pathogen Trypanosoma brucei
… provision of the human pathogen Trypanosoma brucei. ATP is produced in the mitochondrial matrix from ADP and inorganic phosphate by substrate-level and oxidative phosphorylation. To maintain the cellular energy provision, ATP has to be exported from the mitochondrial matrix, and ADP and Pi …
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Methods to Probe the Function of Modified Bases in DNA
… both trypanosomatids and mammalian samples. In T.Brucei, Base J formation is probed by artificial incorporation of 5-hmU and subsequent Base J chemical sequencing. Base J is preferentially formed or depleted at certain genomic loci; suggesting that Base J formation is sequence-specific. This may …