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Showing 1 to 20 of 79 for “"T. brucei"”.
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RNA genome annotation with a focus on T. brucei
… and UTR-indicating patterns in the genome of T. brucei. T. brucei is an interesting organism, and as the cause of African sleeping sickness -- which infects 300,000-500,000 people and a significant number of cattle annually -- is currently the subject of considerable research. Using existing …
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Σχεδιασμός, σύνθεση και φαρμακολογικός έλεγχος αδαμαντανικών αρωματικών ενώσεων κατά του T. brucei
… των ενώσεων της παρούσας εργασίας κατά του T. brucei, ενώ η φαρμακολογική αξιολόγηση βρίσκεται σε εξέλιξη.
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Surface Coat Replacement Dynamics and Antigen Glycosylation in T. Brucei Influence Evasion of the Host Antibody Response
<p>The protozoan parasite Trypanosoma brucei, a causative agent of human and animal trypanosomiasis, evades host immunity through antigenic variation of its variant surface glycoprotein (VSG) coat. During infection, the VSG coat elicits a robust antibody response, but the parasite escapes …
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Untersuchung der eisenabhängigen Regulation des trypanosomalen Transferrinrezeptors in Trypanosoma brucei und Biochemische Charakterisierung einer T. brucei-NMP-Kinase
… beteiligten Proteine sind noch nicht in T. brucei identifiziert. NMP-Kinase sind Enzyme und übertragen einer Phosphatgruppe von einem Nukleosidtriphosphat auf einem Nukleosidmonophosphat und dienen zur Synthese von Nukleosidiphosphat und Recycling von Nukleosidmonphosphat. Bei Trypanosomen …
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Characterisation of factors that regulate homologous recombination and antigenic variation in Trypanosoma brucei
Trypanosoma brucei is an evolutionarily divergent eukaryotic parasite of mammals in sub-Saharan Africa and is transmitted by the tsetse fly vector. To evade the mammalian immune response, T. brucei utilises antigenic variation, which involves switches in the Variant Surface Glycoprotein (VSG) …
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Biological and biochemical characterization of the extracellular signal-regulated kinase 8 homolog (TbERK8) in Trypanosoma brucei
Trypanosoma brucei species are vector-borne protozoan parasites that cause Human African typanosomiasis (HAT) and nagana in cattle. In humans, the diseases caused by these parasites are fatal if left untreated. Treatments for these diseases are complicated because the approved drugs for treatment …
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Novel mitochondrial metabolism in excavate protists
… multiple times within the group. Trypanosoma brucei is a euglenozoan parasite that is responsible for causing Human African trypanosomiasis (HAT) and Nagana in livestock. It has a complex heteroxenous life cycle that involves a variety of complex morphological and biochemical changes to the …
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The Effects of Polysomal mRNA Association and Cap Methylation on Gene Expression in <i>Trypanosoma brucei</i>
Contrasting physiological requirements for T. brucei survival between procyclic (vector) and bloodstream (mammal) forms necessitate different molecular processes and therefore changes in protein expression. Transcriptional regulation is unusual in T. brucei because the arrangement of genes is …
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Investigation of conserved Flagellum proteins in Trypanosoma brucei
The single celled protozoan parasite Trypanosoma brucei is an excellent model organism to study eukaryotic cilia and flagella as it has a single flagellum that remains assembled throughout the cell cycle. The new flagellum assembles in a known position relative to the old flagellum, therefore …
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Essentiality and Regulation of Deoxyhypusination in Trypanosoma brucei
… is caused by protozoan parasite Trypanosoma brucei. T. brucei and other trypanosomatids require spermidine for the formation of trypanothione, a unique thiol-redox factor. In other eukaryotes, spermidine is essential for the (deoxy)hypusination of eukaryotic initiation factor 5A (eIF5A). …
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A Pharmacological Strategy Against African Sleeping Sickness
<p><em>Trypanosoma brucei</em> is a parasitic eukaryote and is the causal agent of the disease known as African sleeping sickness, transmitted via the bite of a tsetse fly. If left untreated, the parasite ultimately crosses the blood-brain eventually leading to death. Currently there are 5 approved …
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Studies on fucosylation in Trypanosoma brucei
… to be essential in the parasite Trypanosoma brucei. Fucose is a common sugar modification on eukaryotic glycan structures, but it has not been well described in trypanosomatids. To elucidate the role of fucose in T. brucei we searched for putative fucosyltransferases in this parasite. A …
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Tracking the In Vivo Dynamics of Antigenic Variation in the African Trypanosome
<p>Trypanosoma brucei, a causative agent of African sleeping sickness in humans and nagana in animals, constantly changes its dense variant surface glycoprotein (VSG) coat to avoid elimination by the immune system of its mammalian host, using an extensive repertoire of dedicated genes. Although …
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The Role of S-Adenosylmethionine Decarboxylase on Regulation of Polyamine and Trypanothione Metabolism in Trypanosoma Brucei
Trypanosoma brucei is the causative agent of Human African Trypanosomiasis (HAT), a fatal and neglected disease affecting Sub-Saharan Africa. Current therapeutics are limited for several reasons, underscoring the need for new and improved drugs. The polyamine/trypanothione pathway is essential for …
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Uncovering the Role of 5'-Nucleotidases in Pyrimidine Metabolism in Trypanosoma brucei
The protozoal parasite Trypanosoma brucei causes the disease African trypanosomiasis in humans and nagana in cattle. Fifty-five million people in subtropical countries are at risk for contracting T. brucei through the tsetse fly vector, and infection is typically fatal if untreated. While recent …
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The PUF proteins in Trypanosoma brucei
The protozoan parasite Trypanosoma brucei, which causes human sleeping sickness, has to adapt to rather different environments as it cycles between the mammalian host and the tsetse fly vector. This adaptation is mediated by changes in trypanosome gene expression, which are mainly regulated at the …
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Mitochondrial ATP production and energy-buffering in the human pathogen Trypanosoma brucei
… provision of the human pathogen Trypanosoma brucei. ATP is produced in the mitochondrial matrix from ADP and inorganic phosphate by substrate-level and oxidative phosphorylation. To maintain the cellular energy provision, ATP has to be exported from the mitochondrial matrix, and ADP and Pi …
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Regulation of Gene Expression in Trypanosoma brucei
<p>The protozoan parasite Trypanosoma brucei is one of the most divergent well-studied eukaryotes and many discoveries of general interest have been made in T. brucei. Atypical for a eukaryote, in T. brucei genes transcribed by RNA polymerase II (RNA pol II) are arranged in polycistronic …
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Factors influencing the spread and selection of drug resistance in Human African Trypanosomiasis
… and propagation of drug resistance in T. brucei. Human African Trypanosomiasis (HAT) is caused by T. brucei gambiense and T. brucei rhodesiense. The few drugs used for the treatment of the disease are either toxic, cause severe side effects or suffer from parasite resistance. The T. brucei …
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Evaluation of Glycogen Synthase Kinase 3 as a drug target in African trypanosomes
… Trypanosomiasis (HAT), caused by Trypanosoma brucei subspecies, is one of the most neglected diseases: available treatments are old, toxic, and difficult to administer; they are not efficacious against all parasite species or disease stages and drug resistance is an increasing problem. Protein …
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