Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"T-type channel"”.
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ACQUIRED ALTERATIONS IN THALAMIC T-TYPE CALCIUM CHANNELS IN MODELS OF NEURONAL HYPEREXCITABILITY
… rhythms, with low-threshold, transient (T-type) Ca2+ channels participating in this activity. The focus of this thesis is on the molecular and physiological alterations in thalamic T-type Ca2+ channels arising from neuronal insults that result in the generation of abnormal brain rhythms. …
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T-type Calcium Channels in Arterial Smooth Muscle: Activity, Regulation and Function
Voltage-gated Ca2+ channels (CaV) are key regulators of excitation-contraction coupling in arterial smooth muscle. Despite evidence of T-type CaV channels in rodent smooth muscle, little is known of their regulation and function. This thesis sought to delineate T-type Ca2+ channels, ascertain if …
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Voltage gated calcium channels – molecular targets for trigeminal neuralgia
… that encode different voltage-gated calcium channels, a class of ion channel that are important players in pain pathways. Among them, mutations in the genes CACANA1A, CACNA1G, and CACNA1H, that encode CaV2.1, CaV3.1 and CaV3.2 channels, respectively, were investigated. First, we characterised …
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Differential modulation of T-type voltage gated calcium channels by G-protein coupled receptors.
T-type voltage-gated calcium (Ca2+) channels play critical roles in controlling neuronal excitability, firing patterns, and synaptic plasticity, although the mechanisms and extent to which T-type Ca2+ channels are modulated by G-protein coupled receptors (GPCRs) remains largely unexplored. …
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The Sandwich Synapse: Trans-glial Signaling Between Neuronal Somata in the Dorsal Root Ganglion
The dorsal root ganglion (DRG) contains the cell bodies of primary somatosensory neurons that form axonal connections for the transfer of sensory input from the peripheral nerve receptor to the spinal cord in the central nervous system. In general, DRG neuronal somata (NS) are each enveloped by …