Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"T-type calcium channels"”.
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T-type calcium channels and human mesangial cell proliferation
… of mesangioproliferative renal diseases. The T-type calcium channel (T-CaCN) has been proposed to play an important role in the proliferation of a number of non-excitable cell types, but T-CaCN expression and functional significance in MC is not known. The aim of this thesis was to investigate …
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Divalent Effects on Permeatin and Gating of T-type calcium channels
… and their membrane potential. Voltage gated calcium channels change both of these properties by allowing Ca2+ to enter the cell, causing membrane depolarization and the entry of Ca2+ which acts as important signaling molecule. Much research over the last few decades has gone into discovering …
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T-type Calcium Channels in Arterial Smooth Muscle: Activity, Regulation and Function
Voltage-gated Ca2+ channels (CaV) are key regulators of excitation-contraction coupling in arterial smooth muscle. Despite evidence of T-type CaV channels in rodent smooth muscle, little is known of their regulation and function. This thesis sought to delineate T-type Ca2+ channels, ascertain if …
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ACQUIRED ALTERATIONS IN THALAMIC T-TYPE CALCIUM CHANNELS IN MODELS OF NEURONAL HYPEREXCITABILITY
… rhythms, with low-threshold, transient (T-type) Ca2+ channels participating in this activity. The focus of this thesis is on the molecular and physiological alterations in thalamic T-type Ca2+ channels arising from neuronal insults that result in the generation of abnormal brain rhythms. …
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Ethosuximide stabilizes sleep-related oscillations and reduces sleep fragmentation during alcohol withdrawal
… importantly, non-REM (NREM) stages of sleep. T-type calcium channels are an important component of the cellular processes that generate and maintain SROs. In two complementary studies, we examined the effects of ethosuximide (ETX), a purported T-type calcium current inhibitor, and genetic …
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Cellular and Circuit Properties of Slow Oscillations In The Thalamic Reticular Nucleus
… reticular nucleus (TRN) generate distinct types of oscillatory activity. While the reciprocal synaptic circuits between TRN and sensory thalamic nuclei underlie the generation of sleep spindles, the mechanisms regulating slow (<1 >Hz) forms of thalamic oscillations are poorly understood. …
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Developmental regulation of smooth muscle contraction in the urinary bladder
… contractions are due to activation of the M3 subtype in both adults and newborns. Activator calcium is mainly recruited from the extracellular space via L-type calcium channels in both adult and newborn tissue. The contractile machinery of the newborn’s bladder tissue is more sensitive to calcium …
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DOES CALCIUM INFLUX THROUGH T-TYPE CALCIUM CHANNEL INDUCE CARDIOMYOCYTE PROLIFERATION?
… of this study is to investigate on how TTCCs (T-type calcium channels) affect cardiomyocyte proliferation. In mice after birth, the major TTCC expressed in the heart is Cav3.1/α1G, and therefore we used Cav3.1/α1G transgenic (TG), knockout (-/-) and wild type mice respectively to define the role …
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Mechanisms of neuronal integration in adrenomedullary sympathetic preganglionic neurons.
… All AD-SPN displayed a high voltage-activated calcium spike that prolongs the action potential. The addition of internal caesium (140mM) revealed a low threshold spike mediated by T-type calcium channels that serve to facilitate burst firing. 75% of AD-SPN exhibited evidence of electrotonic …
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Elucidating the reversibility of ataxia
… are implicated in spinocerebellar ataxia type 5 (SCA5) and spectrin-associated autosomal recessive cerebellar ataxia type 1 (SPARCA1), respectively. Our mouse model, lacking b-III spectrin (KO), mimics the progressive human phenotype displaying motor deficiencies as well as reduced …
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Dendritic properties of inhibitory thalamic neurons: implications in sub-cortical sensory processing
Item reinstated by Sarah Shreeves (sshreeve@illinois.edu) on 2014-06-28T10:00:20Z Item was in collections: Graduate Theses and Dissertations at Illinois (ID: 204) Neuroscience Program Dissertations (ID: 630) No. of bitstreams: 2 Crandall_Shane.pdf: 5543535 bytes, checksum: …