Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"T-type Calcium Channel"”.
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Ethosuximide, a T-type Calcium Channel Antagonist, Reduces Alcohol Withdrawal Seizure
Alcohol is the third highest risk factor for health related problems in the world and leads to over two million deaths per year. Individuals abusing alcohol frequently cycle between drinking and withdrawal states, which among other adverse side effects can induce withdrawal seizures. Alcohol …
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DOES CALCIUM INFLUX THROUGH T-TYPE CALCIUM CHANNEL INDUCE CARDIOMYOCYTE PROLIFERATION?
… of this study is to investigate on how TTCCs (T-type calcium channels) affect cardiomyocyte proliferation. In mice after birth, the major TTCC expressed in the heart is Cav3.1/α1G, and therefore we used Cav3.1/α1G transgenic (TG), knockout (-/-) and wild type mice respectively to define the role …
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Calcium Influx via the T-Type Calcium Channel Plays a Permissive Role in Proliferation of Mouse Embryonic Hl-1 Cells
Cardiac myocytes express two types of voltage operated calcium currents, a high voltage activated (HVA) L-type, and a low voltage activated (LVA) T-type. Influx of calcium into the cell through the L-type channel is responsible for excitation-contraction coupling in the heart. The T-type calcium …
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Insulin-Like Growth Factor-1 Regulation and Subunit Composition of Low-Voltage Activated Calcium Channels in Atrial Myocytes
To test whether the LVA Ca$\sp{2+}$ channel contains $\beta$ subunit, I studied the ability of an AS ON $(\rm\beta\sb{all})$ targeting a common sequence of all four $\beta$ subunits to modulate the LVA Ca$\sp{2+}$ current in atrial myocytes. Our data showed that LVA Ca$\sp{2+}$ channels were …
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Modulation of Axonal Transmission by Metabolic Stress
… modulate the DCMD axon’s performance and what channels are involved in high-frequency signaling that may be a target for metabolic stress. To investigate metabolic stress, we compared azide, a mitochondrial toxin, with starvation of 1- and 4-days. We found azide caused a similar reduction in …
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Design, synthesis, and evaluation of bioactive molecules; Chiral polyvinylpyrrolidones supported Cu/Au nanoclusters catalyzed cyclization of 5-substituted nona-1,8-dien-5-ols
… Oxadiazole derivatives were designed as T-type calcium channel inhibitors, which have potential application in the treatment of seizure and epilepsy. Tricyclic pyrone derivatives were reported as anti-Alzheimer lead compounds in previous research done by the Hua group. TP70 and CP2 were …
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Voltage gated calcium channels – molecular targets for trigeminal neuralgia
… in genes that encode different voltage-gated calcium channels, a class of ion channel that are important players in pain pathways. Among them, mutations in the genes CACANA1A, CACNA1G, and CACNA1H, that encode CaV2.1, CaV3.1 and CaV3.2 channels, respectively, were investigated. First, we …
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Hypothalamic Nutrient Sensing
… that sense them require further study. Using calcium imaging of adult neuron cultures from the mouse mediobasal hypothalamus, I demonstrated that leucine bidirectionally regulates neuronal activity in a neurochemically heterogeneous population of neurons, including AgRP/NPY and POMC neurons. …
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T-type calcium channels and human mesangial cell proliferation
… of mesangioproliferative renal diseases. The T-type calcium channel (T-CaCN) has been proposed to play an important role in the proliferation of a number of non-excitable cell types, but T-CaCN expression and functional significance in MC is not known. The aim of this thesis was to investigate …
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Divalent Effects on Permeatin and Gating of T-type calcium channels
… and their membrane potential. Voltage gated calcium channels change both of these properties by allowing Ca2+ to enter the cell, causing membrane depolarization and the entry of Ca2+ which acts as important signaling molecule. Much research over the last few decades has gone into discovering …
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Elucidating the reversibility of ataxia
… are implicated in spinocerebellar ataxia type 5 (SCA5) and spectrin-associated autosomal recessive cerebellar ataxia type 1 (SPARCA1), respectively. Our mouse model, lacking b-III spectrin (KO), mimics the progressive human phenotype displaying motor deficiencies as well as reduced …