Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 126 for “"T-lymphocyte"”.
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Phosphorylation Regulation of T-Lymphocyte Migration
<p>Immune surveillance requires efficient trafficking of leukocytes throughout the body. To achieve this, leukocytes have evolved to be highly migratory and responsive to environmental cues, which provide guidance for proper tissue distribution. The translation of external environmental cues to …
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Cytotoxic T lymphocyte biology under the microscope
Cytotoxic T lymphocytes (CTLs) are essential agents of the adaptive immune system that seek out and destroy virally infected or cancerous cells. Incapacitate them and you become severely immunocompromised and riddled with tumours (à la prf1-/- mouse model); enhance them and you can beat previously …
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Role of T Lymphocyte Trafficking in Diabetic Cardiomyopathy
… an active area of research. Notably, increased T lymphocyte infiltration into myocardium has been attributed to increased cardiac fibrosis and dysfunction in diabetes. However, the experimental data on the role of T lymphocyte modulation in diabetic myocardial fibrosis is scarce. To this end, …
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The scaffold protein POSH regulates T lymphocyte function
T lymphocytes are critical mediators of the adaptive immune response. T cell receptor (TCR) mediated cJUN NH2-terminal kinase (JNK) activation is required for mounting proper T cell mediated immune responses. However, little is know as to how JNK activation is coupled to the TCR. This dissertation …
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Antigen Recognition by an Alloreactive T Lymphocyte Clone
In chapter two, the ability of CTL 2C to recognize thiol-modified peptide variants is analyzed. A method for the synthesis and screening of thiol-modified peptides that are recognized by T cells is presented. Chapter three continues the peptide variant approach with examination of the ability of …
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T-lymphocyte senescence and hepatitis C virus infection
… efficacy of adaptive immune system function. T-lymphocytes from aged subjects demonstrate multiple phenotypic and functional changes, including telomere shortening. Short telomeres are associated with poor proliferative capacity, pro-inflammatory responses and increased mortality in clinical …
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Characterization of Antigen Recognition by a T Lymphocyte Clone
Chapter Four addresses the physiological T cell responses that can be elicited by peptide/MHC recognition. We demonstrated that the endogenously derived peptide, dEV8, functioned as both an agonist and an antagonist of T cells derived from 2C TCR transgenic mice. Although the exact mechanism …
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Regulation of Human Cytotoxic T Lymphocyte Functions by IL-12
CD8+ T cells or cytotoxic T lymphocytes (CTLs) play a major role in our defense against intracellular pathogens by secreting effector cytokines and directly killing infected cells. Upon sensing of pathogen, antigen presenting cells secrete innate cytokines such as IL-12 and IFN-α. CTL functions are …
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T lymphocyte responses to equid herpesviruses 1 and 4 in horses
… virus-specific proliferative and cytotoxic T lymphocyte (CTL) responses in the blood of horses. Equine T cell blast cells stimulated from peripheral blood mononuclear cells (PBMC) with pokeweed mitogen were found to perform best as targets for CTL in "Cr release assays. CTL induced in vitro …
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Alternate pathways of cytotoxic T lymphocyte and natural killer cell activation
… various species and is involved in the homing of lymphocytes and monocytes to lymph nodes, Peyer's patches, and sites of inflammation. In the present study, we demonstrate that monoclonal antibody (mAb) 9F3, directed against murine CD44 expressed on cytotoxic T lymphocytes (CTls), can trigger the …
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THE EFFECT OF CONFINEMENT ON T-LYMPHOCYTE UPSTREAM MIGRATION UNDER SHEAR FLOW
… One step is migration on the endothelium. CD4+ T-lymphocytes migrate upstream on intracellular adhesion molecule-1 (ICAM-1). In this thesis, we explore the potential of this upstream migration to direct T cells confined within microcontact printed and microfluidic devices. In the first aim, we …
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The role of donor CD4 T lymphocyte chimerism in lung transplant recipients
… recipients is a uniform phenomenon. Donor CD4 T lymphocytes were consistently detected in the recipients’ peripheral blood during the first post-operative month; however, the number of detectable donor CD4 T cells fluctuated over time, and varied between individual lung transplant recipients. In …
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Macrophage regulation of T lymphocyte subsets in normal and tumor- bearing hosts
The mixed lymphocyte reaction (MLR) was used to examine the blastogenic response of normal and tumor-bearing host (TBH) murine T lymphocyte subpopulations in the presence of normal and TBH macrophage (MΦ)-derived factors. Rapidly proliferating normal and TBH Lyt-1⁺ T cells were inhibited by high …
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Raman Spectroscopic Modeling Of T- Lymphocyte Activation And Detection Of Acute Renal Allograft Rejection
… <p>RAMAN SPECTROSCOPIC MODELING OF T-LYMPHOCYTE ACTIVATION AND DETECTION OF ACUTE RENAL ALLOGRAFT REJECTION</p> <p>By</p> <p><strong>KRISTIAN L. BROWN</strong></p> <p>2010</p> <p>Advisor: Gregory Auner, PhD</p> <p>Major: Biomedical Engineering</p> <p>Degree: Doctor of Philosophy</p> …
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Evaluating the predictive performance of cytotoxic T lymphocyte epitope prediction tools using Elispot assay data
Computational T-cell epitope prediction tools have been previously devised to predict potential human leukocyte antigen (HLA) binding peptides from protein sequences. These tools are complements of Enzyme-linked immunosorbent spot (ELISpot) assays - a very commonly applied immunological technique …
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