Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 2 of 2 for “"T-cell survival/persistence"”.
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Mechanistic and Functional Characterization of B and T Lymphocyte Attenuator (Btla) In Cd8 Tumor Infiltrating Lymphocytes
… melanoma patients. Clinical trials of adoptive T-cell therapy (ACT) using autologous <em>ex vivo </em>expanded TIL have demonstrated the great potential of this immunotherapy with an overall clinical response rate 40-50% for stage IV metastatic melanoma patients. We have investigated a number of …
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Characterization of Differentiation and Prognostic Biomarkers On Cd8+ Tumor-Infiltrating Lymphocytes In Metastatic Melanoma
… 44 metastatic melanoma patients using known T-cell differentiation markers. We also compared CD8<sup>+</sup> TIL against the T cells from matched melanoma patients’ peripheral blood. We discovered a novel subset of CD8<sup>+</sup> TIL co-expressing early-differentiation markers, CD27, CD28, and …