Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 14 of 14 for “"T-cell stimulation"”.
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Influence of the potency of antigen presentation on CD8+ T cell differentiation and memory
CD8+ T cells curtail the proliferation of intracellular pathogens. However, the influence of the potency of stimulation on the development of CD8+ T cell memory is not clear. Using recombinant Ovalbumin (OVA) expressing intracellular bacteria, Mycobacterium bovis (BCG) which induces muted T cell …
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Autophagy Delivers Viral Antigens for MHC Class II Presentation and is Regulated by Viral Infection
… II ligands are frequently derived from intracellular proteins after endogenous processing. Endogenous MHC class II antigen presentation has been described for viral and model antigens and might represent an important mechanism to initiate CD4<sup>+</sup> T cell responses to intracellular …
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Human Chimeric Antigen Receptor Macrophages For Cancer Immunotherapy
… advances in chimeric antigen receptor (CAR) T cell immunotherapy for the treatment of human cancer, metastatic solid tumors remain an intractable challenge. Myeloid cells are actively recruited to the tumor microenvironment (TME), where tumor associated macrophages (TAMs) are often the most …
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Regulation and function of the RNA-binding protein CELF1
… gene regulation is a crucial aspect of the cellular control mechanisms that ensure the accurate expression of genetic information. Coordinate regulation of the rate of decay of networks of functionally related mRNA provides a cell the ability to quickly and precisely alter its transcriptome …
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The Role of Alternative Splicing and Alternative Polyadenylation in Regulating Activated T cell Biology
… or association with other factors. T cells provide a unique model to study RNA processing events, such as alternative splicing and polyadenylation, due to the dynamic and robust changes in isoform usage induced upon activation. However, detailed characterization of the regulation of …
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Studies of human T cell costimulation: potential for the immunotherapy of cancer
Costimulation is required for the generation of an effective T cell based immune response. The presentation of tumour associated antigens may occur in the absence of effective costimulation, inducing tolerance. Conversely effective costimulation can overcome immunosuppressive mechanisms present …
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Molecular Mechanisms of Lymphocyte Activation - Please Mind the Gap
… (KS) model of receptor triggering in T cells has been supported by several recent studies. This model proposes that the small gap between an antigen-presenting cell and an immune cell excludes large, inhibitory phosphatases, causing cell signalling. This work examines lymphocyte …
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RNA binding proteins ZFP36 and ZFP36L1 limit CD8+ T cell differentiation and effector function
… where they limit DNA damage response and cell cycle progression. Furthermore, ZFP36L2 has been shown to repress translation of preformed Ifng mRNA and maintain quiescence in CD8+ memory T-cells. However, roles for the ZFP36 proteins in the differentiation and effector functions of CD8+ T …
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T-cell activity in CML patients after TKI discontinuation
Tutkielman aiheena oli kroonista myeloista leukemiaa sairastavien potilaiden T-solujen aktiivisuus ja sytokiinituotanto. Potilasmateriaalina oli ns. STOP-tutkimuksen potilaat, joita on seurattu Hematologisessa tutkimusyksikössä vuodesta 2006. STOP- tutkimuksen yhtenä kiinnostuskohteena oli …
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Understanding T cells in type 1 diabetes: a role for c-Maf and characterization of intracellular signaling following engagement of transgenic Ly49A.
Activated islet specific T cells are central to the destructive autoimmune response observed in type 1 diabetes (T1D). Not surprisingly, intense focus is placed on understanding how autoreactive T cell responses arise and contribute to disease pathology in the hope of using this information to …
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THE ROLE OF DENDRITIC CELLS IN GRAFT REJECTION
… of costimulatory molecules and TLRs in Dendritic Cells (DCs), as a key to the mechanisms underlying the barrier to tolerance induction. Dendritic cells are the sentinels of the immune system. Immature Dendritic cells, which are characterized by low MHC Class II expression and weak T cell …
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THE ROLE OF CD4+ T MEMORY SUBSETS IN HIV INFECTION: IMMUNE RESPONSE IN PEOPLE WITH HIV AND LATENCY ESTABLISHMENT
… and maturation level. Among them, T memory stem cells (TSCM) represent the more developmentally immature subpopulation of the memory pool, endowed with longevity, self-renewing capacity and multipotency, other than recall capabilities. These features make them pivotal for maintaining durable …
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A novel antigen-receptor signalling reporter mouse reveals clonotype-independent intratumoral trapping as a spatial feature of CD8+ T cell exhaustion
… labelled. Combining isolation of the EYFP+ cells with further technologies would enable in-depth analysis of their cell states, clonotype, tissue location, and labelling localization. Validating the AgRSR model, I first showed that the system is robust in its dependencies for TCR signalling …
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Polysequence Nanomaterials for Immunomodulation
… making it difficult to adjust humoral and cellular responses systematically. A vaccine platform containing broadly reactive T-cell epitopes that boosts responses to co-delivered antigens with minimal inflammation could address these limitations. To that end, the focus of this dissertation …