Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 14 of 14 for “"T-cell epitope"”.
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Studies on the molecular mechanism of T cell triggering and detection and characterization of antigen-specific T cells
(cont.) Identification and characterization of T cell epitopes derived from infectious agents or vaccines can greatly enhance the ability to study and eventually direct the immune response. This work contains a description of a novel technique for identifying and characterizing specific T cell …
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Cell surface display in biomedical applications and biofuels production
Cell surface display allows peptides or proteins to be expressed on the cell exterior as fusions to natural host anchoring motifs. It is a powerful technique with a myriad of applications in protein engineering, environmental bioremediation, biocatalysis, as well as vaccine and therapeutics …
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Evaluating the predictive performance of cytotoxic T lymphocyte epitope prediction tools using Elispot assay data
Computational T-cell epitope prediction tools have been previously devised to predict potential human leukocyte antigen (HLA) binding peptides from protein sequences. These tools are complements of Enzyme-linked immunosorbent spot (ELISpot) assays - a very commonly applied immunological technique …
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Studies on the synergistic protective activity of cancer antigens associated to engineered bacterial Outer Membrane Vesicles
… was tested by decorating them with cancer epitopes and by following their capacity to elicit protective immune responses, alone or in combination, using cancer mouse models. Furthermore, we tested whether cancer cell-derived exosomes (TEXs) and OMVs can form complexes and whether such …
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The Relationship of Structure and Immunogenicity of the Bee-Venom Peptide Melittin
… immunogenic structure predicated on binding to cell membranes or other lipophilic environments is suggested. Immunogenicity for antibody responses depends on primary, secondary, and quaternary structure. The distribution of hydrophobic and hydrophilic amino acids determines "peptide-detergent" …
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Systems analysis of the CD4 T cell response induced by the novel subunit tuberculosis vaccine, H1:IC31
… comprehensively analyse antigen-specific CD4 T cell responses induced by vaccination and to examine the effects of latent M. tb infection on these responses. We had two broad objectives: Firstly, to determine the effects of latent M. tb infection on epitope recognition by mycobacteria-specific …
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The Hu Syndrome: At the Intersection of Cancer and Autoimmunity
… expression of a neuronal protein by tumor cells in the periphery results in an autoimmune response that then targets both the tumor and the nervous system. These diseases offer a unique opportunity to gain insight into the mechanisms behind both tumor immunity and neuronal autoimmunity. The …
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Processing of Exogenous Hen Egg-White Lysozyme for Presentation on Major Histocompatibility Complex Class I and II Molecules
… system for processing and presentation to CD4+ T cells. Experiments conducted by Michael Bevan in the 1970s demonstrated that exogenous antigen can also enter the MHC class I system and cross-prime CD8+ T cells; the process by which antigen presentation occurs in this context is termed …
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Supramolecular Peptide Nanofiber Vaccines for Eliciting CD8+ T-cell Responses
CD8+ T cells play a central role in immunity against intracellular pathogens and cancer.Vaccines that elicit robust CD8+ T cell responses are desirable for protection against such infectious diseases and cancers. Subunit vaccines using whole protein or peptide epitopes are becoming increasingly …
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In silico prediction of C57BL/6 mouse T-cell epitopes: enhancing immunogenicity assessment with PREDBL6
… 1) the proteasome selectively cleaves intracellular proteins into short peptides, typically 8–11 amino acids long; 2) TAPs (transporter associated with antigen processing) selectively transport some of these peptides to the endoplasmic reticulum (ER); 3) aminopeptidases may further degrade …
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SYNTHESIS AND STUDY OF ANTI-TUMOR VACCINES
… tumor specific antigen, a 20 amino acid helper T-cell epitope (YAF) derived from an outer membrane protein of Neisseria meningitides and a Rha moiety. Synthesis of the vaccine was achieved by automated Fmoc-based solid phase peptide synthesis and deacetylated by brief treatment with NaOMe. Groups …
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Investigation of Novel Prophylactics Against Human Rotavirus Using Gnotobiotic Pig Models
… three mRNA candidates encoded a universal CD4+ T cell epitope, P2, derived from tetanus toxoid, fused with the encoded VP8* from P[4], P[6], and P[8] HRVs. Two candidates also encoded for a lumazine synthase (LS) domain fused with the P2-VP8*. A dose response study of the LS-P2-VP8* candidates was …
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P0 specific T-cell repertoire in wild-type and P0 deficient mice
Zusammenfassung Das Myelinprotein P0 stellt eine zentrale Komponente für die Stabilität und Funktionalität der Myelinscheiden des peripheren Nervensystems dar. Mutationen des P0-Proteins führen zu verschiedenen, schwer behindernden peripheren Neuropathien wie der Charcot-Marie-Tooth- oder der …
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Patterns of Selection In Hepatitis C and Hiv
… or parallel nonsynonymous changes in CTL epitopes. This pattern is best explained by the frequent re-occurrence of the same set of escape mutations in CTL epitopes of NS3, which are selectively favored within hosts presenting the class I major histocompatability complex molecule, but …