Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 58 for “"T-cell differentiation"”.
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BACH2 orchestrates thymic T cell differentiation and functional programming
… is a highly specialised organ required for T cell development and establishing immunological tolerance. It is tasked with maximising the number of foreign antigens which can be recognised by the T cell receptor (TCR) repertoire in order to protect from infection. Simultaneously, the thymus …
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The role of lactate in CD4+ T cell differentiation and function
… been already studied in the context of CD4+ T cells differentiation, nothing was known about the less abundant D- enantiomeric form until now. By supplementing in vitro cultures of Th1 and Th2 cells with exogenous D- or L-lactate, we describe for the first time D-lactate’s enormous potential to …
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Transdisciplinary Strategies to Study the Mechanisms of CD4+ T cell Differentiation and Heterogeneity
CD4+ T cells mediate and orchestrate a tremendous panoply of lymphoid cell subsets in the human immune system. CD4+ T cells are able to differentiate into either effector pro-inflammatory or regulatory anti-inflammatory subsets depending on the cytokine milieu in their environment. This complex …
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Influence of the potency of antigen presentation on CD8+ T cell differentiation and memory
CD8+ T cells curtail the proliferation of intracellular pathogens. However, the influence of the potency of stimulation on the development of CD8+ T cell memory is not clear. Using recombinant Ovalbumin (OVA) expressing intracellular bacteria, Mycobacterium bovis (BCG) which induces muted T cell …
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Studies on the effect of cysteinyl leukotrienes on human t cell differentiation and function
Antigen-specific Th2 cells are central to the pathogenesis of asthma and other allergic diseases. Th2 cells secrete the cytokines IL-4, IL-5 and IL-13, responsible for many of the features of allergic inflammation such as eosinophilia, IgE production and mucus hypersecretion. Cysteinyl leukotrienes …
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RNA binding proteins ZFP36 and ZFP36L1 limit CD8+ T cell differentiation and effector function
… where they limit DNA damage response and cell cycle progression. Furthermore, ZFP36L2 has been shown to repress translation of preformed Ifng mRNA and maintain quiescence in CD8+ memory T-cells. However, roles for the ZFP36 proteins in the differentiation and effector functions of CD8+ T …
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Functional studies on monoclonal antibodies directed against the T cell differentiation antigens CD3 and CD7
Contains fulltext : mmubn000001_063233231.pdf (Publisher’s version ) (Open Access)
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Hypoxia Acts As An Environmental Cue For The Human Tissue-Resident Memory T-Cell Differentiation Program
<p>Tissue-resident memory T-cells (T<sub>RM</sub>) provide frontline defense against viral diseases and can contribute to anti-tumor immunity; however, aside from the necessity of TGF-β, little is known regarding cues for T<sub>RM</sub> differentiation. Oxygen tension is an environmental cue that …
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USING UNSUPERVISED LEARNING TECHNIQUES TO UNDERSTAND CD8+ T CELL DIFFERENTIATION DURING VIRAL INFECTION AND TUMOR DEVELOPMENT
… latency and autoimmune disease on CD8+ T cell differentiation. To examine how memory CD8+ T cells generated during latency differ from those primed in acute or chronic viral infection, we adoptively transferred naive P14 CD8+ T cells into uninfected recipients, and compared their phenotype …
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REGULATION OF T CELLS AND TISSUE INFLAMMATION BY SHORT CHAIN FATTY ACIDS
… investigated the roles of SCFAs in regulating T cell differentiation and tissue inflammation. We found that SCFAs regulate T cell differentiation and T cell-mediated immunity. SCFAs enhanced both IL-10+ T cell and Th1/Th17 effector T cell differentiation. SCFAs inhibited histone deacetylase …
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ΜΗΧΑΝΙΣΜΟΙ ΟΓΚΟΓΕΝΕΣΗΣ ΔΙΑ ΤΟΥ ΛΕΥΧΑΙΜΟΓΟΝΟΥ ΙΟΥ ΤΟΥ MOLONEY (MOMULV)
… THESE TUMORS CORRESPONDS TO ALL THE STAGES OF T CELL DIFFERENTIATION. THE PROCESS OF ONCOGENESIS IN BOTH ITS EARLY AND LATE STAGES IS DUE TO PROVIRUS MEDIATES INSERTIONAL MUTAGENESIS. USING THE INTEGRATED PROVIRUS AS A MARKER WE HAVE IDENTIFIED AND CHARACTERIZED FIVE INDEPENDENT LOCI TOUR OF …
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Developing Targeted Therapies for T-cell Acute Lymphoblastic Leukemia
… the outcomes of this disease. Compared to B-cell ALL, T-cell ALL (T-ALL) is more aggressive and has worse outcomes from chemotherapy. There is a great unmet need to develop biomarkers and novel targeted therapies for this type of cancer. Working together with internal and external …
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The role of the inflammatory chemokine receptor CCR2 in immune responses to respiratory viral infection
Effector and memory CD8⁺ T cells are critical for the elimination of primary intracellular infections, and for providing rapid immunity upon re-infection. The T cells responding to an infection can take on disparate fates. Although many factors have been described that influence the generation of …
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In vitro generation and programming of human CD8+ memory T cells
… of persistent and functional memory CD8+ T cells. The integration of a multitude of signals during naïve cell activation plays an important role in the programming of CD8+ T cells responses. However, knowledge of the regulation of naïve cell programming in humans is limited. Therefore, we …
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Pre-programmed regulatory networks and poised chromatin potentiate lineage-specific differentiation of CD4+ T cells
… regions of chromatin control the basis for cellular function and identity remains an open question. Here, analysis of regions of accessible chromatin, which are identified globally across T cell subtypes, demonstrates that the chromatin of naïve CD4 T cells is poised towards the acquisition …
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A Single Cell Approach to TCR Signal Strength
… T lymphocytes (CTLs) play a key role in the cell-mediated immune response against virally-infected and tumourigenic cells, killing their targets through the release of cytolytic granules. T cell receptor (TCR) recognition of foreign peptides presented by Class I MHC molecules stimulates naïve …
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On Thymic Regulatory T-Cell Ontogeny
<p>Regulatory T (Treg) cells play a pivotal role in maintaining immune homeostasis and preventing autoimmunity. Like most T cells, Treg development occurs primarily in the thymus, where T-cell precursors undergo a series of developmental stages, including double-negative (DN), double-positive (DP), …
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The role of hypoxia in T cell function and immunotherapy
… a high local metabolic demand depletes immune cells of key metabolites including oxygen. Tumour hypoxia is particularly hostile to antitumour cytotoxic CD8+ T cell function by repressing clonal expansion and by eliciting immune checkpoint mechanisms. However, T cells cultured ex vivo at low …
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Characterization of Differentiation and Prognostic Biomarkers On Cd8+ Tumor-Infiltrating Lymphocytes In Metastatic Melanoma
… fail to undergo tumor regression. We studied the differentiation of the CD8<sup>+</sup> tumor-infiltrating lymphocytes (TIL) from 44 metastatic melanoma patients using known T-cell differentiation markers. We also compared CD8<sup>+</sup> TIL against the T cells from matched melanoma patients’ …
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The immune-modulating activity of Sutherlandia frutescens
… frutescens on the inflammatory response and T cell differentiation in vitro using cytokines as biomarkers. Whole blood cells containing various concentrations of Sutherlandia frutescens were stimulated in vitro with either Lipopolysaccharide (LPS) or Phytohaemagglutinin (PHA). Results show that …
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