Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 15 of 15 for “"T-cell biology"”.
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Advancing multiple model-based control of complex biological systems: Applications in T cell biology
<p>Activated CD4+ T cells are important regulators of the adaptive immune response against invading pathogens and cancerous host cells. The process of activation is mediated by the T cell receptor and a vast network of intracellular signal transduction pathways, which recognize and interpret …
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The Role of Alternative Splicing and Alternative Polyadenylation in Regulating Activated T cell Biology
… or association with other factors. T cells provide a unique model to study RNA processing events, such as alternative splicing and polyadenylation, due to the dynamic and robust changes in isoform usage induced upon activation. However, detailed characterization of the regulation of …
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Development of a canine model to evaluate CAR-T cell subsets
… with chimeric antigen receptor (CAR) T cells has demonstrated success in human blood cancers, although relapse occurs in ~50% of patients. In the context of solid tumors, CAR-T cells show only transient effects. As a "living therapy", development of the next generation CAR-T cells …
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Killer Cell Immunoglobulin-Like Receptors Delineate Distinct Phenotypes and Functions in Human γδ T Cells
Human circulating γδ T cells are broadly classified into three subsets: Vδ1, Vδ2, and Vδ1/2neg populations, with the Vδ2 subset being the most abundant. In this research, I focus on the contribution and interplay of Natural Killer (NK) receptors to the γδ T cell phenotype and function, with …
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Decoding division: single-cell insights into the transcriptional, proteomic and metabolic regulation of proliferating CD4+ T-cells
… for immune-mediated diseases (IMDs). CD4+ T-cells, as key orchestrators of adaptive immunity, encompass a diverse range of subtypes that coordinate and regulate the immune response. Advances in immunogenomics have increasingly linked CD4+ T-cell activation to IMD pathogenesis, highlighting …
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Intrinsic Mechanisms that Regulate T Cell Homeostasis and Function
… unique functional attributes possessed by T cells are initiated after stimulation via their T cell receptor (TCR). Due to the T cell's integral role in immune function, the regulation of signaling events downstream of the TCR have been, and continue to be, an area of intense research. An …
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Noncanonical NF-KB in Gastrointestinal Disease
… such, it has typically been studied in B and T cell biology without application to complex organ systems such as the gut. The following work explores the contribution of noncanonical NF-KB to inflammatory and neoplastic disease in the gastrointestinal (GI) system, as well as the effects of its …
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Mutational Analysis of CD127 and Its Role in Immunological Diseases
… non-redundant cytokine that influences T-cell differentiation, proliferation, homeostasis and T-cell functions. In T-cells, IL-7 signals are transduced via IL-7's heterodimeric receptor composed of a common, γ chain (CD132) and an IL-7 specific, α chain (CD127). In light of the many roles …
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Stochastic and spatiotemporal effects in T-cell signaling
… and the physical sciences to understand how T cells balance the risks of autoimmunity and infection. (1) What features of proteins do T cells search for that correlate with pathogenicity, distinguishing self from foreign? Two contrasting theories have emerged that attempt to describe T cell …
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Quantitative analysis of IL-2 and IL-15 signal transduction in T lymphocytes
… cytokines critically involved in regulation of T cell differentiation and homeostasis. Both cytokines signal through a heterotrimeric surface receptor complex (IL-2/15R) composed of an [alpha], a [beta], and the common gamma ([gamma]c) chain. Signaling occurs through the shared [beta] and [gamma]c …
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Exploring the role and the function of Aryl Hydrocarbon Receptor (AhR) and Aryl Hydrocarbon Nuclear Translocator (ARNT) in T cells
… in the immune system notably in effector Th17 cells where it seems to be critical for the production of the IL-22 cytokine. It is known that AhR ligands such as dioxins can suppress CD8 T cell mediated antiviral immune responses but it is not known whether this reflects a direct role of the AhR …
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Targeting Inflammation in Atherosclerosis: The Role of Low-dose Interleukin 2 in Acute Coronary Syndromes
… without immunosuppression. Regulatory T (Tregs) cells play an important immunomodulatory role in ACS, promoting healing and repair.6 Interleukin 2 (IL-2) is central to Treg cell development and expansion.7 Whilst low-dose IL-2 therapy has been successfully used in autoimmune and inflammatory …
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The dependence of CD4 T cell development and activation on the kinetics of the TCR:pMHC interaction
<p>The T cell is a critical player in the adaptive immune response. T cells function by stimulating antibody production by B cells, secreting cytokines to attract other immune cells, regulating the response of other T cells, and directly killing infected or damaged targets. The role of the adaptive …
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The impact of heptose phosphates on HIV latency and human immune responses
… to promote clearance of HIV infected CD4 T-cells that make up the HIV reservoir to achieve drug-free remission from HIV. Latency reversal agents proposed for shock-and-kill showed suboptimal clinical performance and novel compounds that can promote HIV latency reversal and promote an …
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Cytotoxic T lymphocyte biology under the microscope
… out and destroy virally infected or cancerous cells. Incapacitate them and you become severely immunocompromised and riddled with tumours (à la prf1-/- mouse model); enhance them and you can beat previously unbeatable cancers (e.g., CAR T cell therapy). More than this though, they are …