Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"T-cell Acute Lymphoblastic Leukemia"”.
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Developing Targeted Therapies for T-cell Acute Lymphoblastic Leukemia
<strong>Introduction</strong> Acute lymphoblastic leukemia (ALL) is the most common cancer in children, and risk-adapted chemotherapies have dramatically improved the outcomes of this disease. Compared to B-cell ALL, T-cell ALL (T-ALL) is more aggressive and has worse outcomes from chemotherapy. …
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Genetic Characterization of Pediatric T-cell Acute Lymphoblastic Leukemia
… has been to characterize genetically pediatric T-cell acute lymphoblastic leukemia (T-ALL). Articles I and II focus on molecular characterization of translocations involving T-cell receptor (TCR) loci. These types of aberration are characteristic for T-ALL and have previously proved pivotal in the …
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Characterizing the Role of TLX1 in T-cell Acute Lymphoblastic Leukemia
T-cell Acute Lymphoblastic Leukemias (T-ALLs) are aggressive hematological tumors caused by the aberrant expression of a subset of transcription factors (TFs) in T-cell progenitors1–3 . The identification of diverse sets of secondary mutations in T-ALL tumors suggests a complex process of clonal …
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Notch Signaling Inhibited By Ikaros1 In Human T-Cell Acute Lymphoblastic Leukemia
… conserved Notch signaling pathway regulates cell growth, differentiation, survival and apoptosis. In hematopoiesis, Notch signaling drives commitment to the T-cell fate and promotes differentiation, T-cell receptor signaling and immune function. In T-cells, Notch signaling is oncogenic when …
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Molecular And Therapeutic Implications Of Notch1 Signaling In Pediatric T-Cell Acute Lymphoblastic Leukemia
<p>T-cell acute lymphoblastic leukemia (T-ALL) accounts for 15% of pediatric ALL cases and is associated with early relapse and inferior outcome. The poorer prognosis of T-ALL compared to B-precursor ALL may in part reflect the lack of unique features on which to base therapy. NOTCH1 mutations are …
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Small-molecule inhibition of general transcriptional regulators in cancer
… to these inhibitors. Here, I describe the cellular and molecular effects of inhibiting a general transcriptional regulator, CDK7, in T-cell acute lymphoblastic leukemia (T-ALL) cells. Because tumor cells commonly evolve resistance to individual therapies, I have also investigated the …
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From ribosomal rotation to autism and cancer
… element have been identified in a fraction of T-cell acute lymphoblastic leukemia patients, and these mutants were found to also favor the rotated state. This suggests that a rotational disequilibrium is at the heart of this disease, and a mechanistic model is presented that describes how a …
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Mutational Analysis of CD127 and Its Role in Immunological Diseases
… non-redundant cytokine that influences T-cell differentiation, proliferation, homeostasis and T-cell functions. In T-cells, IL-7 signals are transduced via IL-7's heterodimeric receptor composed of a common, γ chain (CD132) and an IL-7 specific, α chain (CD127). In light of the many roles …