Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 15 of 15 for “"T-box transcription factor"”.
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The role of T-box transcription factor TBX3 in rhabdomyosarcoma
… mechanisms, including the signaling pathways and transcription factors that drive cancer initiation and progression. In this regard, our laboratory has been particularly interested in the embryonically important T - box family of transcription factors which has been heavily implicated in promoting …
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A tumour suppressor role for the T-box transcription factor TBX3 in fibroblasts
TBX3, a member of the developmentally important T-box transcription factor family, has been shown to be overexpressed and to behave as an oncogene in several cancers. Much of this work has, however, been performed in carcinomas of epithelial origin and little is known about the role ofTBX3 in …
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The regulation of the T-box transcription factor TBX3 in Luminal A breast cancer
… in molecular therapies. To this end, the T-box transcription factor, TBX3, has been validated as a potential therapeutic target in breast cancer. TBX3 plays an important role in embryonic development including in the formation of several structures such as the heart, mammary glands, limbs, …
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The <i>Drosophila</i> T-box Transcription Factor Midline Functions within the Insulin/AKT and c-Jun-N-terminal Kinase Signaling Pathways to Regulate Interomatidial Bristle Formation and Cell Survival
… that the <em>Drosophila melanogaster </em>T-box transcription factor <em>midline (mid)</em>, a homolog to the human <em>TBX20 </em>gene, interacts with <em>dFOXO </em>within the insulin receptor (InR) and the c-Jun-N-terminal kinase (JNK) signaling pathways to regulate interommatidial bristle …
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THE ROLE OF T-BET IN LUNG INFECTION
The T-box transcription factor, T-bet, regulates type 1 inflammatory responses against a range of infections. In this thesis, a previously unaddressed role of T-bet, to influenza virus and bacterial superinfection was demonstrated. T-bet deficiency did not adversely affect the efficacy of viral …
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Deciphering the Functional Collaboration of Mid and bric-a-brac 2 as Potential Regulators of Cellular Proliferation Within Adult <i>Drosophila</i> Ovaries
… et al. [2] reported that Gurken/Epidermal Growth Factor Receptor (EGFR) signaling is modulated within posterior ovarian follicle cells by Midline (Mid). The <em>mid</em> gene encodes a T-box transcription factor protein that specifies cell fates in the developing heart [3][4], central nervous …
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Memory Potential, Molecular Characterization, and Translational Applications of The Novel Theo/Tceo T Cell Phenotype
… T cell program typified by expression of the T-box transcription factor Eomesodermin (Eomes) and the co-inhibitory receptor Killer Cell Lectin-like Receptor G1 (KLRG1) which we collectively term ThEO.</p> <p>Herein, we demonstrate that the ThEO phenotype constitutes a stable T cell polarity …
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The Identification of the Mid Transcription Factor Regulatory Network Specifying Cell Fate and Regulating Survival in the <i>Drosophila</i> Eye
<p>The <em>Drosophila melanogaster</em> T-box transcription factor Midline (Mid) exhibits a high degree of structural and functional conservation with its vertebrate homolog Tbx-20. Both Mid and Tbx-20 regulate cell-fate specification with in diverse tissues including the central nervous system …
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Regulatory dynamics of the Tbx18 locus in mouse urogenital development
… contribute to these structures are shared. The T-box transcription factor TBX18 is expressed in these mesenchymal cells and beginning at mid-gestation, Tbx18 expressing cells coalesce on the ureter and urogenital sinus epithelia, then differentiate into the smooth muscle layer. The loss of Tbx18 …
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Transcriptional regulation of thyroid development possible interplay of endoderm- and mesoderm-derived morphogenetic signals
… I, the thyroid expression and function of the T-box transcription factor Tbx1 were examined in wild-type and Tbx1 null mutant mouse embryos. Tbx1 immunoreactivty was present in the splanchic mesoderm adjacent to the thyroid but not in the thyroid progenitors. The thyroid of Tbx1 deficient embryos …
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The role of TBX2 and the anti-cancer activity of chromomycin A5 in pancreatic ductal adenocarcinoma
… need for novel therapeutic strategies. The T-box transcription factor, TBX2, is significantly overexpressed in PDAC tissues and correlates with poor prognosis and distant metastasis, suggesting its potential as a therapeutic target. Recently, Chromomycin A5 (CA5), a marine-derived compound, …
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Eomes Directs the Formation of Spatially and Functionally Diverse Extra-Embryonic Mesoderm Derived Tissues
… revealing both known and novel differences in transcription factors and signalling pathway members. One of the genes showing specificity for early yolk-sac progenitors, is the T-box transcription factor Eomesodermin (Eomes). Eomes is expressed early in gastrulation and plays known roles in …
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The c-Myc/TBX3/nucleolin/Hsc70 signalling axis in breast cancer
The T-box transcription factor TBX3, plays critical roles in development including the formation of the limbs, heart and mammary glands. While haploinsufficiency of TBX3 results in ulnar mammary syndrome, its overexpression is linked to several cancers. We and others have shown that TBX3 drives …
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Regulatory dynamics of transcription factors TBX18 and WT1 in mouse prostate development
The T-box transcription factor TBX18 is essential to mesenchymal cell differentiation in several tissues and Tbx18 loss-of-function results in dramatic organ malformations and perinatal lethality. Although the expression and function of Tbx18 has been analyzed in several tissues, the homozygous …
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The Role of the TBX5-driven Regulatory Network in the Manifestation and Sustainability of Atrial Fibrillation
… and is associated with many well-known risk factors. Within the past decade, there has been a plethora of evidence to suggest that genetic factors also play an important role in the genesis of the arrhythmia, including the T-box transcription factor gene TBX5 and the paired-like homeodomain …