Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 42 for “"T-box"”.
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The role of T-box transcription factor TBX3 in rhabdomyosarcoma
… interested in the embryonically important T - box family of transcription factors which has been heavily implicated in promoting initiation and progression of a long list of cancers. For example, the overexpression of the T - box factor TBX3, has been reported to function in promoting …
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The Expression of T-Box (Tbx3) in the Bovine Mammary Gland
… (GH), insulin-like growth factor (IGF)-I and T-box (Tbx)2 and 3. Tbx2 and Tbx3 are transcription factors required for mammary gland development in humans and known to regulate cell cycle. In addition, there is recent evidence that GH increases expression of Tbx3 in osteoblasts independent of …
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Development of Vessels, Airways and Cartilage Rings: The role of T-box genes
… two closely related genes that belong to the T-box family of transcription factor genes. Loss of Tbx4 results in absence of chorio-allantoic fusion and a failure of formation of the primary vascular plexus of the allantois leading to embryonic death at E10.5. Using a candidate gene approach we …
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A tumour suppressor role for the T-box transcription factor TBX3 in fibroblasts
TBX3, a member of the developmentally important T-box transcription factor family, has been shown to be overexpressed and to behave as an oncogene in several cancers. Much of this work has, however, been performed in carcinomas of epithelial origin and little is known about the role ofTBX3 in …
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The regulation of the T-box transcription factor TBX3 in Luminal A breast cancer
… in molecular therapies. To this end, the T-box transcription factor, TBX3, has been validated as a potential therapeutic target in breast cancer. TBX3 plays an important role in embryonic development including in the formation of several structures such as the heart, mammary glands, limbs, …
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The <i>Drosophila</i> T-box Transcription Factor Midline Functions within the Insulin/AKT and c-Jun-N-terminal Kinase Signaling Pathways to Regulate Interomatidial Bristle Formation and Cell Survival
… that the <em>Drosophila melanogaster </em>T-box transcription factor <em>midline (mid)</em>, a homolog to the human <em>TBX20 </em>gene, interacts with <em>dFOXO </em>within the insulin receptor (InR) and the c-Jun-N-terminal kinase (JNK) signaling pathways to regulate interommatidial bristle …
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The role of the developmentally important transcription factor, TBX2, in the cell cycle and cancer
T-box factors play crucial roles in embryogenesis and mutations in T-box factor genes have been implicated in multiple human disorders. In addition, an increasing body of evidence implicates the T-box family in cell cycle regulation and in cancer...The aim of this study was therefore to address …
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Identification of signalling pathways regulating TBX2 gene expression and its target genes
Members of the T-box family of transcription factors provide an important link between development and cancer. T-box factors play critical roles in embryonic development and results from recent studies suggest that they function in controlling cell cycle progression and also in the genesis of …
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THE ROLE OF T-BET IN LUNG INFECTION
The T-box transcription factor, T-bet, regulates type 1 inflammatory responses against a range of infections. In this thesis, a previously unaddressed role of T-bet, to influenza virus and bacterial superinfection was demonstrated. T-bet deficiency did not adversely affect the efficacy of viral …
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Regulation of the anti-senescence factor, TBX2, by the UV stress signaling pathway and the mitotic cyclin dependent kinases
The T-box gene family has achieved great prominence in the field of developmental biology because its members have been demonstrated to play important roles in embryonic development and mutations within several T-box genes are associated with a number of human congenital diseases. Several lines of …
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Regulation of the anti-senescence factor, TBX2, by the UV stress signalling pathway and the mitotic cyclin dependent kinases
The T-box gene family has achieved great prominence in the field of developmental biology because its members have been demonstrated to play important roles in embryonic development and mutations within several T-box genes are associated with a number of human congenital diseases. Several lines of …
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An investigation into the role of TBX3 in breast carcinogenesis and its regulation by the TGF-?1 signalling pathway
… of the current therapeutic strategies. The T-box family of developmentally important transcription factors plays a role in the genesis of cancer and shows much promise as a focus for targeted therapeutic approaches to treat cancer. For example, the T-box factor TBX3 is overexpressed in a …
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OMB and ORG-1
Members of the T-box gene family encode transcription factors that play key roles during embryonic development and organogenesis of invertebrates and vertebrates. The defining feature of T-box proteins is an about 200 aa large, conserved DNA binding motif, the T domain. Their importance for proper …
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Past Human Behavior Across Time and Space: The Organization of Lithic Technology at Spring Lake, TX, 41HY160
… how activities differed between areas. In the T-Box 6 area during the Late Prehistoric, people were producing and maintaining scrapers and occasionally bifaces. However, they used retouched flakes and discarded projectile points, indicating the presence of formal and expedient technologies. By …
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The role of the transcription factor TBX2 in breast cancer and melanoma and its regulation by the UV-induced DNA damage pathway.
T-box genes constitute an ancient family of developmentally important transcription factors that have gained prominence in cancer biology. For example, endogenous TBX2 is overexpressed in a growing list of cancers and when ectopically overexpressed it can bypass senescence and the tetraploidy …
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Synthesis of Bicyclic and Tricyclic Analogues of Oxazolidinone
… identified to exhibit high affinity for the T box antiterminator transcription system. Among those compounds, ANB-22 and ANB-40 emerged to be the lead compounds showing good RNA-binding activity with high affinity and specificity. In medicinal chemistry, conformationally constraining molecules …
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The Role of Mga in the Survival of Pluripotent Cells During Peri-implantation Development
… transcription factor Mga contains both a T-box binding domain and a basic helix-loop-helix zipper (bHLHZip) domain. Loss of Mga leads to embryonic lethality by E5.5. In vitro blastocyst culture and embryonic stem (ES) cell culture identify a lack of pluripotent inner cell mass (ICM) derived …
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Engineering novel neuronal circuits using HI-PSCS derived neurons and microglia
… supported by the immunocytochemistry (ICC) of T-Box Brain Transcription Factor 1 (TBR1) a characteristic protein of the cerebral cortex. Importantly, our initial MEA data suggests that the electrical activity of cortical neurons increased when co-cultures were performed in the presence of …
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Memory Potential, Molecular Characterization, and Translational Applications of The Novel Theo/Tceo T Cell Phenotype
… T cell program typified by expression of the T-box transcription factor Eomesodermin (Eomes) and the co-inhibitory receptor Killer Cell Lectin-like Receptor G1 (KLRG1) which we collectively term ThEO.</p> <p>Herein, we demonstrate that the ThEO phenotype constitutes a stable T cell polarity …
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