Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 23 for “"T-bet"”.
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THE ROLE OF T-BET IN LUNG INFECTION
The T-box transcription factor, T-bet, regulates type 1 inflammatory responses against a range of infections. In this thesis, a previously unaddressed role of T-bet, to influenza virus and bacterial superinfection was demonstrated. T-bet deficiency did not adversely affect the efficacy of viral …
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T-bet-dependent regulation of T cell responses during Trypanosoma cruzi infection
… into the role of the Th1 transcription factor, T-bet, during murine T. cruzi infection revealed that T-bet is required for resistance. Contrary to our expectations, T-bet was not required for the development of Th1 immunity during infection, as T-bet-deficient mice still developed …
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T-Bet Expressing B Cells With Distinct Residency And Functional Characteristics Give Rise To Plasma Cells
An increasing body of work shows that T-bet+ B cells play important roles in immune responses to infections a well as in autoimmune diseases. These studies investigate the kinetics, tissue distribution, and functions of T-bet+ B cells in a murine influenza infection model. Both T-bet+ and T-bet- …
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Defining the role of the transcription factor T-bet in the innate immune system in intestinal inflammation.
Mice lacking the transcription factor T-bet in the innate immune system (Tbx21-/- x Rag2-/- Ulcerative Colitis, or TRUC) develop microbiota-dependent inflammatory bowel disease (IBD). The innate immune mechanisms responsible for causing disease are still to be resolved, yet potentially offer novel …
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Transcriptional Regulation of T Helper Cell Differentiation in Autoimmunity
… the role of the transcription factors T-bet and PPARalpha in the differentiation and effector function of T helper cells in the EAE model. Based on its ability to induce a pro-inflammatory immune response, T-bet has been found to regulate genes that have been directly linked to …
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Variations in Antigen Presentation Define Regulatory T Cell formation and Activity in Vivo
… drove Treg cells to proliferate and acquire a T-bet+CXCR3+ phenotype, and to suppress the accumulation of CD4+Foxp3- and CD8+ effector T cells in the lungs of infected mice. Notably, when cognate Ag was expressed at high levels by antigen presenting cells, Treg cells also underwent substantial …
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HP Turns 17: T helper 17 cell response during hypersensitivity pneumonitis (HP) and factors controlling it
… a predominant Th17 cell response where both T-bet and TLRs 2 and 9 are controlling T cell response during HP. The results demonstrated a predominant Th17 response associated with granuloma formation in the lungs of C57BL/6J mice during granulomatous and chronic HP. We also found that T-bet KO …
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Regulation of Effector and Memory Development of Human CD4+ T Cells by Interleukin 12 and Type I Interferon
… 12 (IL-12) and type I interferon (IFN-alpha/beta) are produced in response to intracellular bacterial and viral infections. While the effects of IL-12 on CD4+ T cell differentiation are relatively well-understood, the role of IFN-alpha/beta, despite extensive study, has remained …
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REGULATION OF ADAPTIVE IMMUNE RESPONSES TO PLASMODIUM CHABAUDI MALARIA INFECTION
… STAT3 regulate the development of Tfh cells, T-bet and STAT4 direct the commitment of Th1 cells. Since our understanding of the regulation of adaptive protective responses against malaria is poor, the present dissertation aimed to study the development of CD4 T cell responses using the murine …
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Role of Notch Signaling in T Cell Polarization
… Chromatin immuno-precipitations and human T-bet promoter assays support that T-bet and ROR-γt, but not GATA3 are direct targets of Notch1 under Th17 differentiating conditions.</p><p>A role of Notch signaling in T cell differentiation is further validated using Experimental Autoimmune …
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Evolution of adaptive immune response from acute to chronic phase of hepatitis C virus infection
… to prolonged viral exposure. Analysis of T-bet expression revealed that T-bet expression on HCV-specific CD8+ T cell was not associated with clearance. Immuno-phenotyping of liver showed that, liver was enriched with T cells expressing the chemokine receptors CCR2, CCR5, CXCR3, and CXCR6. …
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Transcriptional Regulation of the Inducible Costimulator (ICOS) in T Cells
… undergoing differentiation, we found that T-bet in Th1 or GATA-3 in Th2 cells could enhance, and NFATc2 could further synergize with either of them to increase, icos transcription via the icos promoter or a 3o "UTR element respectively. Finally, we also found that ICOS is controlled at a …
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Defining The Role of Il-15 Trans-Presentation By Distinct Cell-Types During The Development and Homeostasis of Natural Killer and Invariant Natural Killer T Cells
… maturation of mature iNKT cells via enhanced T-bet expression. In conclusion, my work illustrates an important notion that the immunological niche of NK and iNKT cells is tightly regulated and that this regulation is meticulously influenced by the tissue microenvironment.
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Regulation of Anti-Viral Cd8+ T Cell Responses by the Pd-1 Pathway
… mechanism involving the transcription factors T-bet and Eomesodermin. As a result, PD-1 deficiency led to the accumulation of terminally-differentiated, but more cytotoxic, exhausted CD8+ T cells. These findings reveal a novel dual role for PD-1 signals during acutely-resolved and chronic viral …
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Reciprocal Regulation of CD4+ and CD8+ T Lymphocyte Effector and Memory Fates by Interleukin 12 and Type 1 Interferon
… two downstream transcription factors STAT4 and T-bet. Further examination of CD8+ T cells revealed a distinct role for IFN-a/b in the development of a population of central memory T cells (TCM). Alternatively, IL-12 drove the development of effector memory cells (TEM). The variegated development …
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Characterising the immune response to Salmonella and Salmonella surface antigens during a systemic infection
… of infection in an antibody independent, but T-bet-regulated manner. This suggests that the Th2 responses to flagellin are flexible since they can promote Th1 mediated clearance of STm. This moderate protection conferred by sFliC contrasts with the potent benefit conferred by porins. These …
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Identification of novel regulators of lymphocyte development and differentiation using CRISPR-Cas9 screens
… factor reporter mice (including Id2, T-bet, Gata3 and RORγt mice) identified additional potential novel regulators of the ILC developmental network. The application of functional CRISPR-Cas9 screens in primary immune cells has successfully identified new regulators of lymphocyte …
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In vitro generation and programming of human CD8+ memory T cells
… Lef-1 and FoxO1 expression, and an absence of T-bet and Eomes. Collectively, we have established a culture system that enables the exploration of programming events during the priming of naïve human CD8+ T cells that can be further utilized to investigate human CD8+ T cell differentiation and …
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The Role of IL-4 Receptor Alpha signalling on Foxp3 T Regulatory cells in Listeriosis and Tuberculosis
… 7 days post-infection, ultimately translated in better survival. Mechanistically, enhanced Th1 signature with the characteristic T-bet transcriptional factor and increased effector T cells producing IFN-γ, IL-2 following ex-vivo stimulation with PMA/Ionomycin, and heat-killed Lm (HKLM) were …
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Investigating the T cell-specific role of Interleukin-4 receptor alpha (IL-4Rα) in tuberculosis (TB)
… deletion of the receptor on B cells, leads to better control. This thesis aimed to explore the T cell-specific role of IL-4Rα in TB disease by making use of T cell specific knockout model, iLCKCreIL-4Rα-/lox. We found that absence of IL-4Rα on T cells results in a delay in the recruitment of T …
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