Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"T-Brachyury"”.
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The effects of BMP4 on different in vitro models for mouse gastrulation and neural induction
… cells expressing a group of genes that include T/Brachyury. These cells undergo a directed epithelial to mesenchymal transition (EMT) that gives rise to the Primitive Streak. BMP4 mutant mice fail to form a Primitive Streak or do so defectively. Neural induction is the process that gives rise to …
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Date with Destiny: Genetic and Epigenetic Factors in Cell Fate Decisions in Populations of Multipotent Stem Cells
… are identified as cells coexpressing Sox2 and T/Brachyury, a criterion used to derive NMP-like cells from ESCs in vitro. Comparison between the different NMPs protocols stresses that Epiblast Stem Cells (EpiSCs) are an effective source for deriving a multipotent population resembling the embryo …
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The mechanical characteristics and differentiation potential of the axial progenitor region in vertebrate embryos
… of the transcription factors Sox2 and T/Brachyury; it is highly dynamic, expanding and later depleting as axis elongation progresses. The dynamics of WNT and FGF signalling pathways are believed to regulate NMC fate specification. In addition, the progenitor region shows …
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Investigating Wnt3-mediated symmetry breaking and cell fate in engineered gastruloids
Establishment of the anteroposterior (AP) axis in developing mouse embryos is informed by cues from extraembryonic tissues (Arnold & Robertson, 2009; Rivera-Pérez & Magnuson, 2005). In contrast, aggregates of embryonic stem cells (ESCs) termed gastruloids are able to display symmetry breaking and …