Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 28 for “"T-ALL"”.
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Role of Rap and Rho GTPases in T-acute lymphoblastic leukaemia cell adhesion and migration
T-acute lymphoblastic leukaemia (T-ALL) is a common childhood cancer. Multiple genetic mutations have been identified in T-ALL patients. The most common is the mutation of the NOTCH 1 oncogene occurring in more than 50% of patients. Poor prognosis has often been shown to correlate with the …
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Notch Signaling Inhibited By Ikaros1 In Human T-Cell Acute Lymphoblastic Leukemia
… with T-cell acute lymphoblastic leukemia (TALL) have activating Notch mutations. Similarly, Notch activation is present in more than 75% of murine T-ALL models. In murine T-ALL, loss of Ikaros, a zinc finger transcriptional regulator, leads to disrupted differentiation and also cooperates …
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Developing Targeted Therapies for T-cell Acute Lymphoblastic Leukemia
… Acute lymphoblastic leukemia (ALL) is the most common cancer in children, and risk-adapted chemotherapies have dramatically improved the outcomes of this disease. Compared to B-cell ALL, T-cell ALL (T-ALL) is more aggressive and has worse outcomes from chemotherapy. There is a …
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Characterizing the Role of TLX1 in T-cell Acute Lymphoblastic Leukemia
T-cell Acute Lymphoblastic Leukemias (T-ALLs) are aggressive hematological tumors caused by the aberrant expression of a subset of transcription factors (TFs) in T-cell progenitors1–3 . The identification of diverse sets of secondary mutations in T-ALL tumors suggests a complex process of clonal …
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Genetic Characterization of Pediatric T-cell Acute Lymphoblastic Leukemia
… aim of my thesis has been to characterize genetically pediatric T-cell acute lymphoblastic leukemia (T-ALL). Articles I and II focus on molecular characterization of translocations involving T-cell receptor (TCR) loci. These types of aberration are characteristic for T-ALL and have previously …
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Molecular And Therapeutic Implications Of Notch1 Signaling In Pediatric T-Cell Acute Lymphoblastic Leukemia
<p>T-cell acute lymphoblastic leukemia (T-ALL) accounts for 15% of pediatric ALL cases and is associated with early relapse and inferior outcome. The poorer prognosis of T-ALL compared to B-precursor ALL may in part reflect the lack of unique features on which to base therapy. NOTCH1 mutations are …
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An investigation of the role of TRIB2 in steady state and stressed haematopoiesis
… murine T-cell acute lymphoblastic leukaemia (T-ALL) model, Trib2-/- mice had reduced latency in vivo which associated with aggressive T-ALL phenotypes and impaired activation of mitogen-activated protein kinase. Gene set enrichment analysis showed that TRIB2 expression is elevated in immature …
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Structural analysis of LMO2 for the development of a small molecule inhibitor
… a gene located on chromosome 11p13 and was originally discovered through its activation due to specific chromosomal translocations in patients with T-cell acute lymphoblastic leukaemia (T-ALL). The specific chromosomal translocations occur with either the T-cell δ receptor gene (14q11) or T-cell β …
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Characterization of Notch1 and Pi3K-Pten-Akt/Mtor Pathway Interaction In Head and Neck Squamous Cell Carcinoma
… regulates PI3K-AKT and mTOR1 signaling in T-ALL cells by decreasing PTEN expression. In addition, blocking NOTCH1 activity has been shown to upregulate PTEN activity in T-ALL cells via Hes1 downregulation (Palomero T, et al., 2007). Unfortunately, the mechanism of communication between the …
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Untersuchung zur Rolle von Notch1 in T-Zellentwicklung und Lymphomgenese
… der T-Zellentwicklung ist unklar. Die Klonierung aller vier in der Ratte exprimierten Isoformen erlaubte erstmals deren detaillierte Charakterisierung. Die differentielle Expression und die preferentielle Interaktion von Numb i/o mit Notch1 deuten darauf hin, dass den verschiedenen …
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Small-molecule inhibition of general transcriptional regulators in cancer
… CDK7, in T-cell acute lymphoblastic leukemia (T-ALL) cells. Because tumor cells commonly evolve resistance to individual therapies, I have also investigated the potentially synergistic effects of combining two compounds that target transcriptional regulators - the CDK7-inhibitor THZ1 and the …
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Complexity over Finite-Dimensional Algebras
… self-injective k-algebras where k is an algebraically closed field and Ω is the syzygy operator. More precisely, let T be the trivial extension of an iterated tilted algebra of type H. We prove that modules over the trivial extension T all have complexities either 0, 1, 2 or infinity, depending on …
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Molecular Effects of the Nampt Inhibitor FK866 on Leukemia Cells
… of metabolic pathways has emerged as an hallmark of proliferating cancer cells and pharmaceutical approaches targeting cell metabolism hold great potential for cancer treatment. A critical factor in cellular metabolism is nicotinamide adenine dinucleotide (NAD+) and cancer cells highly …
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Ubiquitination of proteins involved in metabolism and immunomodulatory drug sensitivity in lymphocytes
… through binding the D-type cyclins, and historically, a key role has been as a cell cycle regulatory kinase that inactivates G1 checkpoint proteins. More recently, wider roles for Cdk6 have been identified, including as an inhibitor of glycolysis. Notably, Cdk6 has pro-survival activity in T …
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The mechanism of glucocorticoid induced murine thymocyte and peripheral T cell apoptosis
… dafür verantwortlich ist, dass Apoptose in allen T-Lamphozytenarten eingeleitet wird, oder ob noch andere Signalwege existieren. Daher verglichen wir die Rolle des Proteasomes, verschiedener Caspasen, des lysosomalen Kompartements und anderer Faktoren in der durch Glukokortikoide induzierten …
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Metabolic regulation in Phosphatase and tensin homologue (PTEN) null T cell lymphoma/leukaemia cells
… T cell lymphomas in a mouse model for T-ALL. We showed that PTEN-/- T cell lymphoma/leukaemia cells were metabolically active as they readily took up key nutrients. Thus, they had high rates of glucose, glutamine, leucine and transferrin uptake, and expressed constitutively high levels of …
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Comparison of nucleoproteins and nucleic acids of five isolates of tomato ringspot virus
… in Virginia were indistinguishable serologically and symptomologically but could be differentiated into three strains by nucleoprotein and nucleic acid analysis. A grape isolate from one location (GSGF), two grape isolates from another location (GBNR, G4NR), a seed-borne soybean isolate …
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Referrals from Primary Eye Care: An Investigation into their quality, levels of false positives and psychological effect on patients.
… evaluate the quality of referrals to the HES for all ocular pathologies, and also to quantify the proportion of these referrals that were false positive. Any commonality between false positive referrals was investigated. The psychological effect of being referred to the HES was also evaluated …
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Integrating Functional Genomics with Systems Biology to Discover Drivers and Therapeutic Targets of Human Malignancies
… large-sampled primary patients and cell lines allows us to tackle underlying drivers causally associated with tumorigenesis or drug-resistance. In my dissertation, I have developed a framework to integrate functional RNAi screens with systems biology of cancer genomics to tailor potential …
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Culturally Informed Motivational Interviewing to Improve Oral Chemotherapy Adherence for Pediatric Acute Lymphoblastic Leukemia Patients and Their Caregivers: A Feasibility, Acceptability, and Preliminary Efficacy Trial
… for childhood acute lymphoblastic leukemia (ALL) mandates a two-to-three-year maintenance chemotherapy phase wherein patients must take daily oral 6-mercaptopurine (6-MP). 6-MP regimen adherence is challenging and failure to take medication has been associated with an increase in relapse …
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