Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 37 for “"T regulatory cells"”.
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Activation of T regulatory cells in Type II Immune Responses
… We examined changes in subsets of CD4+ T cells, CD4+CD25+CD127lo T regulatory cells (Treg), and B cells of patients on dialysis (ESKD) and renal graft recipients of varying lengths, and compared them to healthy volunteers. Demonstrating the heterogeneity of Treg, Miyara et al. (2009) have …
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Novel markers for human T regulatory cells in healthy donors and cancer patients
CD4+CD25+FoxP3+ T regulatory cells (Tregs) are essential for maintaining self-tolerance and preventing autoimmune diseases. However, FoxP3+ Tregs contribute to the progression of cancer and their levels expand in cancer patients compared to healthy donors. Tregs suppress tumour-specific immune …
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Regulation of the germinal center reaction by T helper cells and T regulatory cells
… Within the GC, follicular T helper (TFH) cells promote GC B cell differentiation and in turn the proper antibody production to protect us from invading pathogens. We wished to study the regulation of this process by transcription factors STAT3 and Bcl6. STAT3 is important for both TFH cell …
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T-Regulatory Cells and FLT3-Ligand in the Therapy of Cockroach Antigen-induced Asthma
… (AHR) and airway inflammation. Many inflammatory cells, including mast cells, eosinophils, neutrophils, and lymphocytes, are critical in the initiation of the pathophysiological changes in asthma. The mobilization and recruitment of these inflammatory cells are primarily due to the release of …
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Immunotolerance regeneration by T regulatory cells in autologous haematopoietic stem cell transplantation for multiple sclerosis
… ablation of autoreactive immune cells and the regeneration of immunoregulatory lymphocytes, such as CD4+ T regulatory cells (Tregs). Tregs expressing the ectonucleotidase enzyme CD39 exert immunoregulatory function by suppressing T helper (Th)17-related immune responses, which has …
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Mechanisms Mediating Asthma Tolerance Induced By Regulatory Dendritic Cells Through CD4+CD25+Foxp3+ T Regulatory Cells
IL-10-treated tolerogenic dendritic cells (DC10) have been used as a powerful tool for the treatment of experimental asthmatic responses. We explored the important role of CD4+CD25+Foxp3+ regulatory T cells (Treg) in the induction of tolerance by DC10 in three levels. We first used the siRNA …
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Investigating the role of IL-4Rα mediated signalling on Foxp3⁺ T regulatory cells during cutaneous leishmaniasis
… alpha chain (IL-4Rα). Forkhead box P3 (Foxp3⁺) Regulatory T (Treg) cells are an unique subset of CD4⁺ T cells that play important immunomodulatory roles maintaining a balance between Type 1 and Type 2 immune responses. During L. major-induced cutaneous leishmaniasis, Treg cells accumulation at …
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The Role of IL-4 Receptor Alpha signalling on Foxp3 T Regulatory cells in Listeriosis and Tuberculosis
T regulatory cells are critical in the maintenance of self-tolerance, immune homeostasis and regulation of the immune system. Cytokine signalling is a dominant component of environmental signals which controls the function of Forkhead box P3 (Foxp3) regulatory T cells. This thesis addressed the …
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Validation of shellfish isolates (glycosaminoglycans, GAGs) for development as a novel anti-tumour therapy for children : GAG action on lymphocytes/T-regulatory cells
Introduction: Leukaemia is cancer of white blood cells (WBCs) mainly affecting children. Defective WBCs are prominent in blood and cannot provide immune protection. Although chemotherapy treatments are effective, they have many adverse effects which are magnified in children, with treatment proving …
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The Participation of Transforming Growth Factor Beta in Tumor Immunoevasion
… in the generation of peripheral CD8+CD25 + T regulatory cells. Our findings suggest that in the presence of high concentrations of TGFbeta1, strong costimulatory strength is permissive for the induction of CD8+ T cells possessing suppressor functions. Our studies also demonstrate that the …
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Immune Mechanisms of Mesenchymal Stem Cell Therapy for Acute Graft versus Host Disease
… was to investigate the role of Mesenchymal stem cells (MSC) in the modulation of immune responses, focusing on suppression and induction of immune tolerance. To date, MSC therapy has proved beneficial for the treatment of inflammatory and autoimmune diseases, such as acute Graft versus Host …
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FVIII Immunity : early events and tolerance mechanisms to FVIII
… the use of FVIII-pulsed immature dendritic cells in inducing immune tolerance against FVIII prior to the FVIII treatment. We showed that in vivo, FVIII does not induce the activation and proliferation of hemophilic T cells. Furthermore, infusing FVIII-pulsed immature dendritic cells into …
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The bi-directional relationship between gut microbiota and autoimmunity
… of disease by upregulating the expression of T regulatory cells. Further, we show that a genetically engineered Lactococcus lactis expressing the colonization factor antigen I from Escherichia coli acting as an immunomodulatory probiotic reduced the severity of disease.</p>
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Destruction of Corneal Nerves Promotes Corneal Allograft Rejection
… expression of pro-apoptotic factors on corneal cells ; and 3.) the induction of a form of immune tolerance called anterior chamber-associated immune deviation (ACAID). Immune privilege contributes to the 90% success rate of corneal allografts without the need for histocompatibility matching and …
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Intestinal cancer : linking infection, inflammation and neoplasia
… cancer, and using immune regulating cells as treatment for intestinal cancer. For the first objective, a murine mutational analysis model was used to study infection with Citrobacter rodentium, an enteric bacterium that causes self-limiting hyperplasia and inflammation. Increased …
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Low-dose IL-2 for T-regulatory cell expansion after alemtuzumab therapy in relapsing-remitting multiple sclerosis
T-regulatory cells (Tregs) are vital for the prevention of autoimmunity, and they require interleukin-2 to function optimally. Their expression of the high-affinity IL-2 receptor, containing the CD25 subunit, renders them 10-fold more sensitive to IL-2 than effector cells (Teffs). Low-dose IL-2 …
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THE ABSENCE OF C3AR AND C5AR SIGNAL TRANSDUCTION PROMOTES T REGULATORY CELL DIFFERENTIATION AND REGULATES IMMUNOLOGIC TOLERANCE
… and C5aR signals are not transduced into CD4+ T cells, PI-3K¿-AKT-mTOR signaling ceases, PKA activation increases, auto-inductive TGF-ß1 signaling initiates, and CD4+ T cells become Foxp3+ T regulatory cells (iTregs). Endogenous TGF-ß1 suppresses C3aR and C5aR signaling by preventing C3a and C5a …
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EGF module-containing mucin-like hormone receptor 2 and its role in human immune privilege
… F4/80, is required for the development of regulatory T cells in two models of tolerance, the eye and gut. Since F4/80 is not expressed in humans, the purpose of this research is to determine the human analog of F4/80. F4/80 belongs to a novel family of Epidermal growth factor-seven …
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Role of CD4+CD25+ Regulatory T Lymphocytes in Experimental Toxoplasmosis
… study was to investigate the role of CD4+CD25+ T regulatory lymphocytes in mice infected with <i>Toxoplasma gondii</i>. T regulatory (Treg) cells have been shown to play an important role in our immune system in controlling the activity of other T lymphocytes. These cells are differentiated from …
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Investigating role of IL-4 receptor alpha (IL-4Ra) in murine models of atopic dermatitis
… antibodies, characterise the disease. B and T cells are essential in the disease manifestation, however, the exact mechanism of how these cells are involved in skin sensitization to allergens is unclear. Clinical studies investigating the efficacy of monoclonal antibody to IgE such as …
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