Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 45 for “"T helper cells"”.
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Regulation of the germinal center reaction by T helper cells and T regulatory cells
… antigen. Within the GC, follicular T helper (TFH) cells promote GC B cell differentiation and in turn the proper antibody production to protect us from invading pathogens. We wished to study the regulation of this process by transcription factors STAT3 and Bcl6. STAT3 is important for …
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Stochastic gene expression during lineage specification of single T helper lymphocytes
… inventory comprised of highly specialized cells, the differentiation of which requires numerous lineage specifications at various developmental stages. The precise control of immune cell differentiation and the delicate balance of their population composition are crucial for effective …
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Suppression of T-Helper Cell Function by a Soluble Immunosuppressive Factor From Plasmodium Berghei Infected Rat Erythrocytes
… (ISF) and then immunized with sheep red blood cells (SRBC) had a reduced number of plaque forming cells (PFC) as compared to mice injected with control preparations. The delayed type hypersensitivity reaction elicited by SRBC was also suppressed in mice treated with the ISF. Purification by …
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Transcription factor regulation of T helper subset function
… protects the body from foreign organisms. T cells and B cells are integral components of the ability of the immune system to generate focused immune responses. The development of specialized subsets of T helper cells is governed by transcription factors. Previous work demonstrated a …
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Regulation of Adaptive and Innate Immunity by the Circadian Transcription Factor NFIL3
… adaptive and innate immunity by regulating TH17 cells and innate lymphoid cells (ILCs), respectively. First, NFIL3 transcriptionally represses RORgt, the master regulator of TH17 cells, by directly binding to the Rorgt promoter and thereby suppresses TH17 cell development from naïve T helper …
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Bioinformatic tools for single-cell data analysis in clinical studies
… in combating this problem, since each sample of cells represents hundreds to thousands of observations But thinking is still emerging on how best to utilize single-cell data to boost statistics and generate meaningful findings This thesis represents several parallel efforts to develop and apply …
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Exploring the adaptive immune response to Oncogene-Induced-Senescence
… is associated with the accumulation of senescent cells within the liver. Senescence is an acutely tumour-suppressive, but chronically pro-tumorigenic stress-responsive cell pathway. Senescent cells signal to immunocytes through a complex secretome, to trigger their own CD4+ T-cell dependent …
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Probabilistic modelling of cellular development from single-cell gene expression
… molecular, transcriptional, changes in cells as they develop. I reviewed the literature on the technology, and made a large scale quantitative comparison of the different implementations of single cell RNA sequencing to identify their technical limitations. I investigate how to model …
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ADAM10: a Novel Regulator of Mast Cell Function and Activation
… description of the role ADAM10 plays on mast cells. ADAM10 is abundantly expressed on mast cells both in vitro and in vivo. Its expression is inhibited by IL-10, a suppressive cytokine. siRNA depletion of ADAM10 on bone marrow-derived mast cells (BMMC) caused decreased IL-6 production …
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Understanding the function of ICOS/ICOSL costimulation in experimental autoimmune myasthenia gravis
… cell expansion, whereas the number of CD4+ T helper cells was increased. Collectively, these results indicate that lymphocyte costimulation through the ICOS/ICOSL pathway is a vital component of the adaptive immune response to AChR in EAMG.\r\n
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Modulation of Neutrophil Functions and Anti-Tumor Immune Responses by Innate Suppressors
… through cellular contact with cancer cells and/or other immune cells such as T helper cells. However, molecular mechanisms that modulate functional adaptations of neutrophils are not well understood. The objective of my thesis is to identify the role of Tollip, a novel TLR signaling …
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Anthropometric, metabolic and immunological factors in overweight/obesity and their influence on the responsiveness to a nutritional intervention for body weight management.
… (white blood cell counts and neutrophil, total T helper cells (CD4+), naive T helper cells (CD4+RA+) counts), increased red blood cell haemoglobin concentration and levels of circulating non-esterified fatty acids. Body fat %, anthropometric indices, and all other blood variables analysed did not …
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HIV-1 Transgenic Rats Display Alterations in Immunophenotype and Cellular Responses Associated with Aging
… In the HIV-1Tg rats, the percentage of T cells decreased with aging, particularly with T cytotoxic cells, whereas T helper cells were increased with age. Neutrophil and monocyte cell numbers increased in HIV-1Tg rats during maturation compared to age-matched control rats. Aging HIV-1Tg …
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Twist1 and Etv5 are part of a transcription factor network defining T helper cell identity
CD4 T helper cells control immunity to pathogens and the development of inflammatory disease by acquiring the ability to secrete effector cytokines. Cytokine responsiveness is a critical component of the ability of cells to respond to the extracellular milieu by activating Signal Transducer and …
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Soy Isoflavone Supplementation Does Not Alter Distribution of Circulating Lymphocytes or Natural Killer Cell Activity in Postmenopausal Women
… baseline and on d 28 to assess distribution of T-helper cells (CD3+CD4+), T-cytotoxic cells (CD3+CD8+), total T lymphocytes (CD3+), B lymphocytes (CD19+) and natural killer (NK) cells (CD16+CD56+) via flow cytometry. Cytotoxicity of NK cells was quantified based on lactate dehydrogenase release of …
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HIV-1 Immune Escape and Neutralizing Antibodies : Solid Phase Proteoliposomes Containing HIV-1 Envelope Glycoproteins as Antigens and Immunogens and HIV-1 Core Envelope Glycoproteins Deficient in T-Helper Epitopes
… binding and fusion of the virus to target cells. The envelope glycoproteins are exposed on the surface of the virus as trimeric spikes and are the major targets for neutralizing antibodies. The design of envelope glycoprotein-based subunit vaccines has been frustrated by many viral immune …
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Equine interferon-gamma and associated cytokines
… responses. Upon encounter with antigen, CD4+ T cells are able to influence the character of the immune response elicited through the expression of distinct types of cytokines. Thl cytokines, especially IFN-γ but also TNF-β and IL-2, constitute one such pattern of expression, promoting cell …
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T Helper Cell Dysfunction in ANCA Associated Vasculitis
… that leads to organ dysfunction. Auto-reactive B cells produce pathogenic antibodies against the neutrophil enzymes, myeloperoxidase (MPO) and proteinase 3 (PR3). Genome-wide association studies that identified the relationship between MHC class II genes and ANCA specificity strongly support the …
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Batf regulates previously unknown AP-1 target genes to control TH17 differentiation
… which lacks a TAD, is highly expressed in T helper cells compared to various other immune cells and tissues. IL-17-producing T helper: TH17) cells are a CD4+ T cell subset that coordinates inflammatory responses in host defense but are pathogenic in autoimmunity. To study the role of Batf in …
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Immunopathogenic mechanisms of non-healing cutaneous leishmaniasis caused by Leishmania amazonensis infection
… to evade host immune components, particularly B cells and interferon-gamma. Our data have shown that L. amazonensis infection induces B cell activation, leading to enhanced lesion development. In the absence of B cells, L. amazonensis-infected mice developed a delayed onset of disease, …
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