Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 31 for “"T helper cell"”.
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T Helper Cell Dysfunction in ANCA Associated Vasculitis
… that leads to organ dysfunction. Auto-reactive B cells produce pathogenic antibodies against the neutrophil enzymes, myeloperoxidase (MPO) and proteinase 3 (PR3). Genome-wide association studies that identified the relationship between MHC class II genes and ANCA specificity strongly support the …
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Transcriptional Regulation of T Helper Cell Differentiation in Autoimmunity
… significance of transcriptional regulation of Th cells in MS pathogenesis, we investigated the role of the transcription factors T-bet and PPARalpha in the differentiation and effector function of T helper cells in the EAE model. Based on its ability to induce a pro-inflammatory immune response, …
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Aging Dendritic Cell Function and Effects on T Helper Cell Differentiation
… but previously published data suggest dendritic cells (DC) largely escape this phenomenon. DC have three main functions: upregulation of cell surface expression of costimulatory molecules, antigen presentation, and cytokine secretion which lead to activation of T cells. The milieu of secreted …
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Transcription factors and cis-acting elements in T helper cell cytokine expression
… inflammation and autoimmune disease. CD4+ T cells, which play a crucial role in adaptive immune system, can be divided into several subsets based on their effector functions. T helper 9 (Th9) cells, derived by the IL-4/STAT6 and TGF-β signaling pathways, produce IL-9 as a hallmark cytokine, …
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Metabolic Mechanisms of Nutritionally Regulated Hormone Signaling on T Helper Cell Function
… hormones communicate nutritional status to cells and tissues throughout the body. In the case of overnutrition or obesity, levels of leptin, insulin, and insulin like growth factor 1 (IGF-1) are increased, whereas they are decreased in the setting of undernutrition. Either undernutrition or …
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Twist1 and Etv5 are part of a transcription factor network defining T helper cell identity
CD4 T helper cells control immunity to pathogens and the development of inflammatory disease by acquiring the ability to secrete effector cytokines. Cytokine responsiveness is a critical component of the ability of cells to respond to the extracellular milieu by activating Signal Transducer and …
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Environmental stimuli shape adaptive immunity by enhancing T helper cell differentiation and the germinal centre response
Immune cells have evolved to respond to external danger signals and to incorporate information about environmental cues to adapt their differentiation and effector function. Because of this, it is important that immune cells are studied in the context of their surroundings. In this thesis, I …
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Engineering T Cell Receptors to Examine the Role of Affinity and *Kinetics in T Helper Cell Function
Chapter five details the engineering of a class II restricted human TCR isolated from a patient with multiple sclerosis called 3A6. Yeast display of TCRs has previously relied on the use of an antibody specific for a properly folded TCR, here various strategies were used to generate stabilized 3A6 …
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Suppression of T-Helper Cell Function by a Soluble Immunosuppressive Factor From Plasmodium Berghei Infected Rat Erythrocytes
… (ISF) and then immunized with sheep red blood cells (SRBC) had a reduced number of plaque forming cells (PFC) as compared to mice injected with control preparations. The delayed type hypersensitivity reaction elicited by SRBC was also suppressed in mice treated with the ISF. Purification by …
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The role of Hedgehog signalling in T cell effector function
CD8+ and CD4+ T cells are critical effector cells of the immune system. CD8+ T cells specifically recognise and kill virally-infected and malignant cells. Mature naïve CD4+ T cells can polarise in the periphery into various lineages that orchestrate immune programmes in response to a variety of …
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Induction of anti-ergotamine antibodies in mice and steers and protection against fescue toxicosis in mice
… to vaccination. Hyperprolactinemia decreases cell-mediated and humoral immune responses in mice. Therefore, steers grazing EI or endophyte-free (EF) fescue forages were vaccinated to assess humoral immune responses. Steers grazing EI fescue exhibited classical clinical signs of fescue …
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Characterizing physiological and genetic differences in the early immune response to Haemonchus contortus in resistant and susceptible sheep
… lymph node as both breeds expressed a general T-helper cell type 2 (TH2) response. However, profound differences in TH2 responses were observed in the abomasal mucosa, where hair sheep expressed more IL-4, -13 and -33 than wool sheep. These data thus document the presence of immunological …
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Stat3 Inhibits Type I Interferon Signaling In Type I Conventional Dendritic Cells
<p>Conventional dendritic cells (cDCs) are an essential immune population, responsible for controlling adaptive immunity and tolerance. Recently, type I cDCs (cDC1s) have been delineated as a distinct cDC subset, uniquely responsible for coordinating T cell-mediated immunity against pathogens and …
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Regulation of Effector and Memory Development of Human CD4+ T Cells by Interleukin 12 and Type I Interferon
… of adaptive immune responses such as CD4+ T helper cell development. For instance, the innate cytokines interleukin 12 (IL-12) and type I interferon (IFN-alpha/beta) are produced in response to intracellular bacterial and viral infections. While the effects of IL-12 on CD4+ T cell …
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A role for polyunsaturated fatty acids in Th1-mediated disease
… method of action remains elusive. Dendritic cells (DC) are the most potent antigen presenting cell (APC) and we found that n-3 and n-6 PUFA suppressed IL-12p70 and enhanced IL-10 production rendering the DC less inflammatory. Furthermore, PUFA inhibited DC maturation by impeding the …
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Molecular Mechanisms of Protection from Hepatitis C Infection
… infection and are at risk of cirrhosis and hepatocellular carcinoma. There is currently no preventative vaccine available for HCV. In the developed world, the highest HCV incidence and prevalence rate is amongst intravenous drug users (IDU). The duration, frequency of IDU, and sharing of drug …
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Identification and Characterization of the Cis-acting Elements Around the Murine cd4 Cnhancer
… glycoprotein. CD4 is essential for normal T helper cell function and plays an important role in T cell development and activation. CD4 is encoded by a single gene located on chromosome 6 in the mouse and chromosome 12 in the human. Both human and murine CD4 genes are divided into ten exons …
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Human immunodeficiency virus (HIV)-mediated cardiac fibrosis: implication of cellular immunomodulation and cytokine profile alterations
… and chronic inflammation, which in turn disrupt cellular immunomodulation and increase susceptibility to cardiac fibrosis. To test this hypothesis, we evaluated changes in T-cell subsets (T-helper cell 1 (Th1) and T-helper cell 2 (Th2)), monocyte/macrophage subsets (macrophage type 1 (M1) and …
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Characterising the immunometabolic profile of HIV/TB co-infection
… increase of cytokines typically classified as T helper cell type (Th) 1 or Th2, and as pro-inflammatory or immunoregulatory, suggests a failure of immunoregulation, resulting in an increased disease burden. Metabolites indicative of cachexia, damage of the intestinal mucosa and dysbiosis of the …
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Plant-based Multicomponent Vaccines against Enteric Diseases
… cytometry analysis of immunized mouse spleen cells showed an increase in CD4+ T -helper cell populations. Following rotavirus challenge, passively immunized mouse pups showed a 50% reduction in diarrhea symptoms.</p> <p>To generate a plant-based subunit vaccine against rotavirus, we have …
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