Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"T helper 17 (Th17)"”.
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ESTROGEN, VASCULAR INFLAMMATION, AND INTERLEUKIN-17 IN RELATION TO ATHEROSCLEROSIS IN A FEMALE NONHUMAN PRIMATE MODEL
The role of T helper 17 (Th17) cells and interleukin-17A (IL-17A), a signature pro-inflammatory cytokine for Th17, in atherosclerosis is unknown. Postmenopausal estrogen therapy (ET) mediates atheroprotection in part through anti-inflammatory effects; however, the effects of ET on Th17 cells and …
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Functional Characterisation of a Novel Tir-Domain containing Protein in Immune Signalling
… rigidly control such signalling pathways. The IL-17 family of cytokines, which comprises six members in mammals, are potent mediators of inflammation. Produced primarily by CD4+ T helper 17 (Th17) cells, they signal through IL-17 receptor family complexes and protect the host against bacterial …
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HDAC6 Deletion Decreases Pristane-Induced Inflammation and Lupus
… decreased some lymphocyte populations like T-helper 17 (Th17) cells after pristane treatment while not affecting other cell populations, such as regulatory T cells, total T cells, B cells, and plasma cells. Taken together, these results demonstrate that although HDAC6 inhibition may inhibit …
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The role of PU.1 and IRF4 interaction in the biology and function of T helper 2 cells
… of immune responses is coordinated by CD4+ T-helper (Th) cells. Depending on the cytokine environment, Th progenitor (Thp) cells differentiate into three functionally different effector subsets. T-helper-1 (Th1) cells which mediate cell-mediated immunity, T-helper-2 (Th2) which orchestrates …
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Environmental stimuli shape adaptive immunity by enhancing T helper cell differentiation and the germinal centre response
… ER stress response acts as a potent driver of T helper 17 (Th17) cell differentiation resulting in Th17 cells with a pathogenic gene expression signature. This suggests a link between ER stress-inducing conditions such as low nutrient availability, and the pathology of Th17 cell-mediated …
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Identification of Therapeutic Targets for Th17 Cell-Mediated Diseases
… of environmental, genetic and other factors. T helper 17 (Th17) cells play a critical role in the immune pathology. Th17 cells are a group of specialized CD4+ T cells with potential pro-inflammatory function which are different from other T cells such as T helper 1 (Th1) cells or T helper 2 …
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Metabolic Mechanisms of Nutritionally Regulated Hormone Signaling on T Helper Cell Function
… been shown to directly promote inflammatory T helper 1 (Th1) and T helper 17 (Th17) cell differentiation and function. Since T cells have a critical role in driving inflammation and systemic glucose intolerance in obesity, we sought to determine the role of leptin signaling in this context. …
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Investigating the immune modulatory properties of kisspeptin: implications for pregnancy
… of the adaptive T regulatory (aTreg)/T-helper 17 (Th17) cells, induction of the enzyme indoleamine 2,3-dioxygenase (IDO) and regulation of monocyte function during pregnancy. In addition, kisspeptin has been implicated in the regulation of specific cytokines during pregnancy. It is …
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The impact of viral infection during pregnancy on maternal immunity and fetal brain development
… of IAV: (1) maternal adaptive immune cells, T helper 17 (TH17) lymphocytes, and their effector cytokine, IL-17, drive inflammatory cascades that signal to the fetal brain and induce neocortical malformations, and (2) fetal brain-resident macrophages respond to maternal viral inflammation and …
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Alterations in endometrial immune cell populations affect endometrial cell functions
… infertility. Among other immune cells, the T-helper lymphocytes accumulate in the normal endometrium during the mid- to late-secretory phase of the menstrual cycle and are considered essential for endometrial receptivity. The goal of this project was to 1) study the relationship between …
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Effects of potato fiber and soluble corn fiber on the fecal microbiome of dogs with implications to inflammation
… cytokines (TNF-α, IL-1β, IL-6, and IL-17A). What was particularly interesting were the changes in distal colon gene expression of CXCL1, which is a neutrophil chemoattractant. Mice provided non-fermentable Cell had a 7-fold increase (P < 0.05) in CXCL1 expression compared with all other …
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The Effects of Immunomodulatory Agents On the Development of Experimental Autoimmune Encephalomyelitis
… demonstrated that CD4+ T-cell subsets Th1 and Th17, play a significant role in driving disease progression. Current treatment consists of anti-inflammatory or immunosuppressive drugs in an attempt to suppress the production of pro-inflammatory cytokines as well as the activation, expansion, and …