Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 19 of 19 for “"T helper 17"”.
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Toll Like Receptor Dependent Control of T Helper 17 Cell Differentiation and Inflammasome Activation
… play an important role in differentiation of Th17 cells in vitro. IL-1 has also been implicated in regulating Th17 differentiation. In this dissertation, we examined the relative contribution of IL-6 and IL-1 for in vivo Th17 differentiation, and found that requirements for Th17 polarization …
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Molecular Mechanisms Underlying The Transcriptional Regulation of T Helper 17 and Regulatory T Cells
<p>CD4<sup>+</sup> T helper (Th) lymphocytes are vital for integrating immune responses by orchestrating the function of other immune cell types. Naïve Th cells can differentiate into different effector subsets that are characterized by their cytokine profile and immune regulatory functions. These …
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The generation and maintenance of T Helper 17 cells in response to bacterial infection
… (TGF-β1) as sufficient to induce T helper type-17 (TH17) differentiation in vitro, but it is unclear whether these factors are necessary, and if so, what the cellular source of these factors is in the context of a TH17 inducing infection in vivo. Moreover, studies of the TH17 …
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HP Turns 17: T helper 17 cell response during hypersensitivity pneumonitis (HP) and factors controlling it
… that HP is associated with a predominant Th17 cell response where both T-bet and TLRs 2 and 9 are controlling T cell response during HP. The results demonstrated a predominant Th17 response associated with granuloma formation in the lungs of C57BL/6J mice during granulomatous and chronic HP. …
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ESTROGEN, VASCULAR INFLAMMATION, AND INTERLEUKIN-17 IN RELATION TO ATHEROSCLEROSIS IN A FEMALE NONHUMAN PRIMATE MODEL
The role of T helper 17 (Th17) cells and interleukin-17A (IL-17A), a signature pro-inflammatory cytokine for Th17, in atherosclerosis is unknown. Postmenopausal estrogen therapy (ET) mediates atheroprotection in part through anti-inflammatory effects; however, the effects of ET on Th17 cells and …
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Functional Characterisation of a Novel Tir-Domain containing Protein in Immune Signalling
… rigidly control such signalling pathways. The IL-17 family of cytokines, which comprises six members in mammals, are potent mediators of inflammation. Produced primarily by CD4+ T helper 17 (Th17) cells, they signal through IL-17 receptor family complexes and protect the host against bacterial …
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HDAC6 Deletion Decreases Pristane-Induced Inflammation and Lupus
… decreased some lymphocyte populations like T-helper 17 (Th17) cells after pristane treatment while not affecting other cell populations, such as regulatory T cells, total T cells, B cells, and plasma cells. Taken together, these results demonstrate that although HDAC6 inhibition may inhibit …
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The role of PU.1 and IRF4 interaction in the biology and function of T helper 2 cells
… of immune responses is coordinated by CD4+ T-helper (Th) cells. Depending on the cytokine environment, Th progenitor (Thp) cells differentiate into three functionally different effector subsets. T-helper-1 (Th1) cells which mediate cell-mediated immunity, T-helper-2 (Th2) which orchestrates …
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Role of Notch Signaling in T Cell Polarization
… of the effector subsets recently discovered is Thelper 17 (Th17) and it plays a predominant role in autoimmune diseases and inflammatory disorders.</p><p>In my thesis, I aimed to study the role of Notch cell surface receptors in Th17 differentiation. Using in vitro Th17 differentiation assays of …
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Environmental stimuli shape adaptive immunity by enhancing T helper cell differentiation and the germinal centre response
… ER stress response acts as a potent driver of T helper 17 (Th17) cell differentiation resulting in Th17 cells with a pathogenic gene expression signature. This suggests a link between ER stress-inducing conditions such as low nutrient availability, and the pathology of Th17 cell-mediated …
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Identification of Therapeutic Targets for Th17 Cell-Mediated Diseases
… of environmental, genetic and other factors. T helper 17 (Th17) cells play a critical role in the immune pathology. Th17 cells are a group of specialized CD4+ T cells with potential pro-inflammatory function which are different from other T cells such as T helper 1 (Th1) cells or T helper 2 …
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Characterizing the roles of gut microbiota, probiotic Lactobacilli and CX3CR1 in the development of autoimmunity in MRL/lpr mice
… the imbalance between regulatory T cells and T helper-17 cells. To further understand the role of Lactobacillus spp., we treated MRL/lpr mice with the combined culture supernatant of the 5 strains containing secreted metabolites, given that the metabolites may induce an immunosuppressive …
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Metabolic Mechanisms of Nutritionally Regulated Hormone Signaling on T Helper Cell Function
… been shown to directly promote inflammatory T helper 1 (Th1) and T helper 17 (Th17) cell differentiation and function. Since T cells have a critical role in driving inflammation and systemic glucose intolerance in obesity, we sought to determine the role of leptin signaling in this context. …
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Investigating the immune modulatory properties of kisspeptin: implications for pregnancy
… of the adaptive T regulatory (aTreg)/T-helper 17 (Th17) cells, induction of the enzyme indoleamine 2,3-dioxygenase (IDO) and regulation of monocyte function during pregnancy. In addition, kisspeptin has been implicated in the regulation of specific cytokines during pregnancy. It is …
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The impact of viral infection during pregnancy on maternal immunity and fetal brain development
… of IAV: (1) maternal adaptive immune cells, T helper 17 (TH17) lymphocytes, and their effector cytokine, IL-17, drive inflammatory cascades that signal to the fetal brain and induce neocortical malformations, and (2) fetal brain-resident macrophages respond to maternal viral inflammation and …
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Alterations in endometrial immune cell populations affect endometrial cell functions
… infertility. Among other immune cells, the T-helper lymphocytes accumulate in the normal endometrium during the mid- to late-secretory phase of the menstrual cycle and are considered essential for endometrial receptivity. The goal of this project was to 1) study the relationship between …
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Effects of potato fiber and soluble corn fiber on the fecal microbiome of dogs with implications to inflammation
… cytokines (TNF-α, IL-1β, IL-6, and IL-17A). What was particularly interesting were the changes in distal colon gene expression of CXCL1, which is a neutrophil chemoattractant. Mice provided non-fermentable Cell had a 7-fold increase (P < 0.05) in CXCL1 expression compared with all other …
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The Effects of Immunomodulatory Agents On the Development of Experimental Autoimmune Encephalomyelitis
… demonstrated that CD4+ T-cell subsets Th1 and Th17, play a significant role in driving disease progression. Current treatment consists of anti-inflammatory or immunosuppressive drugs in an attempt to suppress the production of pro-inflammatory cytokines as well as the activation, expansion, and …